{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:28:36Z","timestamp":1791365316804,"version":"4.3.1"},"reference-count":26,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Hirschsprung\u2019s disease (HD) is characterized by a congenital absence of enteric ganglion cells in the intestine, posing challenges in diagnosis, particularly in pediatric patients. The gold standard, rectal suction biopsy (RSB), carries risks, prompting an exploration of non-invasive alternatives such as high-resolution anorectal manometry (HR-ARM) for HD screening. We conducted a retrospective analysis of 136 patients suspected of HD between 2018 and 2022, which were stratified into three age groups: \u226412 months, \u226424 months, and &gt;24 months. Criteria for suspicion included delayed meconium passage, unresponsive chronic constipation, and abnormal prior test results. HR-ARM, supplemented by additional tests, confirmed 16 HD cases. HR-ARM exhibited 93.75% sensitivity, 89.47% specificity, 99.03% negative predictive value (NPV), and 55.56% positive predictive value (PPV). Notably, HR-ARM consistently performed well in patients \u2264 2 years old but demonstrated reduced efficacy in older children, which was likely due to complications from chronic constipation. This study underscores HR-ARM\u2019s promise as a non-invasive HD screening tool, especially in younger patients. However, its limitations in older children warrant consideration. Establishing standardized protocols, particularly for assessing the recto-anal inhibitory reflex, is crucial. Further research is imperative to optimize HR-ARM\u2019s diagnostic role across varied age groups in HD assessment.<\/jats:p>","DOI":"10.3390\/jcm13051268","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T04:31:23Z","timestamp":1708662683000},"page":"1268","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["High-Resolution Anorectal Manometry as a Screening Tool for Hirschsprung\u2019s Disease: A Comprehensive Retrospective Analysis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2057-8765","authenticated-orcid":false,"given":"Oliver","family":"Sowulewski","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Gastroenterology, Allergology & Paediatric Nutrition, Medical University of Gda\u0144sk, 80-210 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Bubi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Gastroenterology, Allergology & Paediatric Nutrition, Medical University of Gda\u0144sk, 80-210 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Zagierska","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Gastroenterology, Allergology & Paediatric Nutrition, Medical University of Gda\u0144sk, 80-210 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Zagierski","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Gastroenterology, Allergology & Paediatric Nutrition, Medical University of Gda\u0144sk, 80-210 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5992-4414","authenticated-orcid":false,"given":"Agnieszka","family":"Szlagatys-Sidorkiewicz","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Gastroenterology, Allergology & Paediatric Nutrition, Medical University of Gda\u0144sk, 80-210 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2013.03.001","article-title":"The Developmental Etiology and Pathogenesis of Hirschsprung Disease","volume":"162","author":"Trainor","year":"2013","journal-title":"Transl. 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