{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T22:17:52Z","timestamp":1789251472228,"version":"build-2803163510"},"reference-count":56,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T00:00:00Z","timestamp":1708732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: There have been no reports of sepsis-induced agranulocytosis causing gingival necrosis in otherwise medically healthy patients to the authors\u2019 best knowledge. Even though there are several case reports of gingival necrosis secondary to medication-induced agranulocytosis, they have not systematically described the natural progression of agranulocytosis-related gingival necrosis. Methods: This paper presents a case report of a 29-year-old female Indian patient with generalised gingival necrosis and constitutive signs of intermittent fever, nausea, and vomiting. She also complained of abdominal pains. Blood counts showed agranulocytosis, and the patient was admitted for a workup of the underlying cause. Parenteral broad-spectrum antibiotics were administered, which brought about clinical resolution. Results: Her gingival necrosis was attributed to sepsis-induced agranulocytosis triggered by Pseudomonas aeruginosa bacteraemia, and upon clinical recovery, spontaneous exfoliation left behind exposed bone. Secondary healing over the exposed alveolar bone was noted after a year-long follow-up, albeit with some residual gingival recession. Conclusions: Oral manifestations of gingival necrosis, when present with concomitant constitutive symptoms, could indicate a serious underlying systemic condition that could be potentially life-threatening if left untreated. Dentists should be cognizant of this possibility so that timely intervention is not delayed.<\/jats:p>","DOI":"10.3390\/jcm13051285","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T03:34:04Z","timestamp":1708918444000},"page":"1285","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Gingival Necrosis Related to Sepsis-Induced Agranulocytosis Due to Pseudomonas aeruginosa Bacteraemia: A Case Report"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3147-8409","authenticated-orcid":false,"given":"Jia Ying","family":"Tan","sequence":"first","affiliation":[{"name":"Private Practice, Singapore 428927, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo Nian","family":"Teo","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, National Dental Centre, Singapore 168938, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7538-7866","authenticated-orcid":false,"given":"Ethan","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, National Dental Centre, Singapore 168938, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew Ban Guan","family":"Tay","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, National Dental Centre, Singapore 168938, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3042-3103","authenticated-orcid":false,"given":"John Rong Hao","family":"Tay","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry, National Dental Centre, Singapore 168938, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.immuni.2021.06.006","article-title":"The Neutrophil","volume":"54","author":"Burn","year":"2021","journal-title":"Immunity"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Andr\u00e8s, E., Lorenzo Villalba, N., Zulfiqar, A.-A., Serraj, K., Mourot-Cottet, R., and Gottenberg, J.-E. 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