{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:47:28Z","timestamp":1760143648581,"version":"build-2065373602"},"reference-count":41,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,2,25]],"date-time":"2024-02-25T00:00:00Z","timestamp":1708819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Rapidly destructive osteoarthritis (RDO) of the hip joint is characterised by the rapid destruction of the femoral head with or without acetabular involvement. There has been increasing interest in this disease over the past years; however, the entity is still poorly understood, and its pathophysiology remains unknown. Yet, there is ample evidence today that increased bone metabolism might play a role in the onset and progression of the disease. Vitamin D is of utmost importance to maintain a balanced bone metabolism. However, whether vitamin D deficiency is involved in disease development remains to be elucidated. Further, the vitamin D status of patients with RDO has not yet been analysed. For this reason, the objective of this study was to assess the vitamin D status of patients with RDO. Moreover, the aim was to clarify whether there is a difference in the vitamin D status of patients with RDO compared with patients with primary osteoarthritis (OA). Methods: In this single-centre analysis, the 25(OH)D, PTH, and calcium levels of 29 patients who presented with RDO between 2020 and 2022 were assessed. Results: Altogether, 97% of patients (28\/29) were vitamin D deficient, a further 3% (1\/29) were vitamin D insufficient, and not a single patient presented with a sufficient vitamin D status. Notably, the vitamin D levels of RDO patients (mean = 11.04 ng\/mL) were significantly lower than the vitamin D levels of patients with OA (mean = 22.16 ng\/mL, p = 0.001). Conclusion: In conclusion, we found a widespread and high rate of vitamin D deficiency in patients with RDO. Hence, we believe that 25(OH)D status should routinely be analysed in these patients.<\/jats:p>","DOI":"10.3390\/jcm13051296","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T03:34:04Z","timestamp":1708918444000},"page":"1296","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Vitamin D Deficiency Is Frequent in Patients with Rapidly Destructive Osteoarthritis\u2014Data from a Single-Center Analysis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9086-3541","authenticated-orcid":false,"given":"Konstantin","family":"Horas","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Koenig-Ludwig-Haus, University of Wuerzburg, 97074 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerrit","family":"Maier","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Pius-Hospital, Carl-von-Ossietzky-University, 26121 Oldenburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4982-6594","authenticated-orcid":false,"given":"Maximilian","family":"Rudert","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Koenig-Ludwig-Haus, University of Wuerzburg, 97074 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9362-2914","authenticated-orcid":false,"given":"Axel","family":"Jakuscheit","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Koenig-Ludwig-Haus, University of Wuerzburg, 97074 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3551-3204","authenticated-orcid":false,"given":"Manuel","family":"Wei\u00dfenberger","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Koenig-Ludwig-Haus, University of Wuerzburg, 97074 Wuerzburg, Germany"},{"name":"Orthopaedic Surgery Centre Wuerzburg (OCW), 97070 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5522-0092","authenticated-orcid":false,"given":"Ioannis","family":"Stratos","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Koenig-Ludwig-Haus, University of Wuerzburg, 97074 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tizian","family":"Heinz","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Koenig-Ludwig-Haus, University of Wuerzburg, 97074 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"Rak","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Koenig-Ludwig-Haus, University of Wuerzburg, 97074 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2356-547X","authenticated-orcid":false,"given":"Philip Mark","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Koenig-Ludwig-Haus, University of Wuerzburg, 97074 Wuerzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Arnholdt","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Trauma Surgery, Musculoskeletal University Center Munich (MUM), LMU University Hospital, 81377 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,25]]},"reference":[{"key":"ref_1","unstructured":"Forestier, F. (1957). Coxites Rhumatismales Subaigues et Chroniques. [Ph.D. Thesis, Sorbonne University]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1148\/radiology.182.1.1727284","article-title":"Rapid destructive osteoarthritis: Clinical, radiographic, and pathologic features","volume":"182","author":"Rosenberg","year":"1992","journal-title":"Radiology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.artd.2020.04.005","article-title":"Rapidly Progressive Osteoarthritis and Acetabular Bone Loss Outcomes for Patients Undergoing Primary Total Hip Replacement","volume":"6","author":"Karayiannis","year":"2020","journal-title":"Arthroplast. Today"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s00590-015-1676-4","article-title":"Rapid destructive arthritis of the hip revisited","volume":"25","author":"Mavrogenis","year":"2015","journal-title":"Eur. J. Orthop. Surg. Traumatol. Orthop. Traumatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1007\/s00590-022-03396-8","article-title":"The outcomes of total hip arthroplasty in rapidly progressive osteoarthritis: A systematic review","volume":"33","author":"Baryeh","year":"2023","journal-title":"Eur. J. Orthop. Surg. Traumatol. Orthop. Traumatol."},{"key":"ref_6","first-page":"138","article-title":"Total prosthetic replacement in rapidly destructive arthrosis of the hip joint","volume":"72","author":"Postel","year":"1970","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1007\/s00256-021-03815-7","article-title":"Rapidly progressive idiopathic arthritis of the hip: Incidence and risk factors in a controlled cohort study of 1471 patients after intra-articular corticosteroid injection","volume":"50","author":"Boutin","year":"2021","journal-title":"Skelet. Radiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.21037\/apm.2020.03.17","article-title":"The mysteries of rapidly destructive arthrosis of the hip joint: A systemic literature review","volume":"9","author":"Hu","year":"2020","journal-title":"Ann. Palliat. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1749-799X-3-3","article-title":"Rapidly destructive osteoarthritis of the hip joint: A case series","volume":"3","author":"Batra","year":"2008","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.arth.2009.03.007","article-title":"Total hip arthroplasty using Kerboull-type acetabular reinforcement device for rapidly destructive coxarthrosis","volume":"25","author":"Kawai","year":"2010","journal-title":"J. Arthroplast."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11420-009-9112-0","article-title":"Total hip arthroplasty in rapidly destructive osteoarthritis of the hip: A case series","volume":"5","author":"Kuo","year":"2009","journal-title":"HSS J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/jor.22573","article-title":"Massive accumulation of osteoclastic giant cells in rapid destructive hip disease","volume":"32","author":"Seitz","year":"2014","journal-title":"J. Orthop. Res. Off. Publ. Orthop. Res. Soc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/ajcp\/aqab127","article-title":"Destructive Arthropathy of the Femoral Head","volume":"157","author":"Layfield","year":"2022","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s11914-012-0098-z","article-title":"Vitamin D and bone","volume":"10","author":"Bikle","year":"2012","journal-title":"Curr. Osteoporos. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"100329","DOI":"10.1016\/j.jbo.2020.100329","article-title":"Does vitamin D deficiency predict tumour malignancy in patients with bone tumours? Data from a multi-center cohort analysis","volume":"25","author":"Horas","year":"2020","journal-title":"J Bone Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1055\/s-0038-1673534","article-title":"The Role of Vitamin D and the Vitamin D Receptor in Bone Oncology","volume":"27","author":"Horas","year":"2018","journal-title":"Osteologie"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Wang, L.T., Chen, L.R., and Chen, K.H. (2023). Hormone-Related and Drug-Induced Osteoporosis: A Cellular and Molecular Overview. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24065814"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.2106\/JBJS.RVW.16.00084","article-title":"Vitamin D in Orthopaedics","volume":"5","author":"Tran","year":"2017","journal-title":"JBJS Rev."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Kupisz-Urba\u0144ska, M., P\u0142udowski, P., and Marcinowska-Suchowierska, E. (2021). Vitamin D Deficiency in Older Patients-Problems of Sarcopenia, Drug Interactions, Management in Deficiency. Nutrients, 13.","DOI":"10.3390\/nu13041247"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J. Clin. Endocrinol. metab."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s00774-007-0761-0","article-title":"Mature and activated osteoclasts exist in the synovium of rapidly destructive coxarthrosis","volume":"25","author":"Ogawa","year":"2007","journal-title":"J. Bone Miner. Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/230949900501300107","article-title":"Microvascular density of rapidly destructive arthropathy of the hip joint","volume":"13","author":"Yamakawa","year":"2005","journal-title":"J. Orthop. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF00246872","article-title":"Synovial, articular cartilage and bone changes in rapidly destructive arthropathy (osteoarthritis) of the hip","volume":"12","author":"Mitrovic","year":"1992","journal-title":"Rheumatol. Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.5152\/eurjrheum.2020.20046","article-title":"Bone turnover markers in the early stage of rapidly progressive osteoarthritis of the hip","volume":"8","author":"Yasuda","year":"2021","journal-title":"Eur. J. Rheumatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s12603-011-0003-y","article-title":"Nutritional approach for inhibiting bone resorption in institutionalized elderly women with vitamin D insufficiency and high prevalence of fracture","volume":"15","author":"Bonjour","year":"2011","journal-title":"J. Nutr. Health Aging"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"698","DOI":"10.3945\/jn.111.153692","article-title":"Consumption of vitamin D-and calcium-fortified soft white cheese lowers the biochemical marker of bone resorption TRAP 5b in postmenopausal women at moderate risk of osteoporosis fracture","volume":"142","author":"Bonjour","year":"2012","journal-title":"J. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.cca.2005.12.031","article-title":"Bone resorption markers in vitamin D insufficiency","volume":"368","author":"Need","year":"2006","journal-title":"Clin. Chim. Acta"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s00774-013-0501-6","article-title":"Bone mineral density in patients with destructive arthrosis of the hip joint","volume":"32","author":"Okano","year":"2014","journal-title":"J. Bone Miner. Metab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e586","DOI":"10.5435\/JAAOS-D-19-00604","article-title":"The Use of Cement in Hip Arthroplasty: A Contemporary Perspective","volume":"28","author":"Blankstein","year":"2020","journal-title":"J. Am. Acad. Orthop. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"8079354","DOI":"10.1155\/2016\/8079354","article-title":"The Importance of Bone Mineral Density in Hip Arthroplasty: Results of a Survey Asking Orthopaedic Surgeons about Their Opinions and Attitudes Concerning Osteoporosis and Hip Arthroplasty","volume":"2016","author":"Maier","year":"2016","journal-title":"Adv. Orthop."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s11154-017-9424-1","article-title":"The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention","volume":"18","author":"Holick","year":"2017","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3390\/nu5010111","article-title":"Vitamin D\u2014Effects on skeletal and extraskeletal health and the need for supplementation","volume":"5","author":"Wacker","year":"2013","journal-title":"Nutrients"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.jcot.2019.07.004","article-title":"Vitamin D for skeletal and non-skeletal health: What we should know","volume":"10","author":"Charoenngam","year":"2019","journal-title":"J. Clin. Orthop. Trauma"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Holick, M.F. (2010). Vitamin D: Physiology, Molecular Biology, and Clinical Applications, Humana Press.","DOI":"10.1007\/978-1-60327-303-9"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"942","DOI":"10.21037\/atm-21-779","article-title":"The role of vitamin D and vitamin D deficiency in orthopaedics and traumatology\u2014A narrative overview of the literature","volume":"9","author":"Maier","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/jgs.18601","article-title":"Impact of vitamin D deficiency on mortality in patients with hip fracture: A meta-analysis","volume":"72","author":"Llombart","year":"2024","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Kim, D.S., and Lee, J.S. (2023). Vitamin D in adolescent idiopathic scoliosis: A meta-analysis. BMC Musculoskelet. Disord., 24.","DOI":"10.1186\/s12891-023-06793-0"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1177\/1758573220906520","article-title":"Vitamin D deficiency and total shoulder arthroplasty complications","volume":"13","author":"Smith","year":"2021","journal-title":"Shoulder Elb."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/sj.ejcn.1602825","article-title":"Vitamin D status and health correlates among German adults","volume":"62","author":"Hintzpeter","year":"2008","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1002\/mnfr.200900494","article-title":"The estimated benefits of vitamin D for Germany","volume":"54","author":"Zittermann","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e6395","DOI":"10.1097\/MD.0000000000006395","article-title":"Clinico-radiological diagnosis and grading of rapidly progressive osteoarthritis of the hip","volume":"96","author":"Zazgyva","year":"2017","journal-title":"Medicine"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/5\/1296\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:04:32Z","timestamp":1760105072000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/5\/1296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,25]]},"references-count":41,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["jcm13051296"],"URL":"https:\/\/doi.org\/10.3390\/jcm13051296","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2024,2,25]]}}}