{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:57:06Z","timestamp":1788263826586,"version":"build-2803163510"},"reference-count":16,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Cancer Research UK","award":["C11497\/A28789"],"award-info":[{"award-number":["C11497\/A28789"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: The need for surgical reconstruction of scalp defects following the excision of cutaneous skin cancers is an increasingly common procedure. Particular challenges arise when considering options for reconstruction of large defects not amenable to local skin flap coverage. The use of skin grafts poses the risk of donor site morbidity. This paper investigates the emerging use of Integra\u00ae, a synthetic acellular dermal regeneration template, as an alternative or adjunct to skin grafting in scalp reconstruction. Methods: The study presents a retrospective analysis of 101 patients who underwent Integra\u00ae-based reconstruction of scalp defects. Demographics, procedure details, complications, need for further surgery, and time to healing were evaluated. Results: The overall success rate of the one-stage Integra\u00ae-only procedure was 95%, with a minor complication rate of 30.7%. Anticoagulation medication was identified as an independent risk factor for post-operative infection, while previous head and neck radiotherapy and increased defect depth were associated with the requirement for a second-stage skin graft. Conclusions: These findings support the consideration of Integra\u00ae as a safe and viable alternative for both partial and full thickness scalp defects in a select cohort of complex highly co-morbid patients, reducing complications and the need for additional procedures.<\/jats:p>","DOI":"10.3390\/jcm13051511","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T04:03:50Z","timestamp":1709697830000},"page":"1511","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Integra\u00ae Dermal Regeneration Template in Complex Scalp Reconstruction"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2623-5305","authenticated-orcid":false,"given":"Natalie","family":"Turton","sequence":"first","affiliation":[{"name":"Worcestershire Acute Hospitals NHS Trust, Worcestershire WR5 1DD, UK"},{"name":"Birmingham Medical School, University of Birmingham, Birmingham B15 2TT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaina","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Worcestershire Acute Hospitals NHS Trust, Worcestershire WR5 1DD, UK"},{"name":"Birmingham Medical School, University of Birmingham, Birmingham B15 2TT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eoin","family":"Twohig","sequence":"additional","affiliation":[{"name":"Worcestershire Acute Hospitals NHS Trust, Worcestershire WR5 1DD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Worcestershire Acute Hospitals NHS Trust, Worcestershire WR5 1DD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kieron","family":"McVeigh","sequence":"additional","affiliation":[{"name":"Worcestershire Acute Hospitals NHS Trust, Worcestershire WR5 1DD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal","family":"Barnard","sequence":"additional","affiliation":[{"name":"Worcestershire Acute Hospitals NHS Trust, Worcestershire WR5 1DD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Payne","sequence":"additional","affiliation":[{"name":"Worcestershire Acute Hospitals NHS Trust, Worcestershire WR5 1DD, UK"},{"name":"Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B15 2TT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,6]]},"reference":[{"key":"ref_1","first-page":"349","article-title":"Reconstruction of Complex Scalp Defects in Different Locations: Suggestions for Puzzle","volume":"55","author":"Bas","year":"2021","journal-title":"Med. 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Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jcms.2016.11.023","article-title":"Scalp Reconstruction: A 10-year Retrospective Study","volume":"45","author":"Steiner","year":"2017","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_15","first-page":"e245","article-title":"Reconstruction of Full Thickness Scalp Defects After Tumour Excision in Elderly Patients: Our Experience with Integra\u00ae Dermal Regeneration Template","volume":"63","author":"Corradino","year":"2010","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Zelin, E., Maronese, C.A., Dri, A., Toffoli, L., Di Meo, N., Nazzaro, G., and Zalaudek, I. (2022). Identifying Candidates for Immunotherapy Among Patients with Non-Melanoma Skin Cancer: A Review of the Potential Predictors of Response. J. Clin. 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