{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:51:29Z","timestamp":1760143889353,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: LBBAP is a promising method of cardiac pacing. Data on some follow-up details are still limited. We aimed to evaluate LBBAP over a one-year follow-up period. Methods: The studied population consisted of 110 patients who underwent LBBAP device implantation (93 for bradycardia indications, 17 for CRT). Echocardiography and NT-proBNP measurement were performed before the procedure and after one year. Electrical parameters, complications and some other conditions that required attention were noted during the observation period. Results: In total, 89 patients completed the one-year follow-up. NT-proBNP and echocardiographic parameters (LVEF, left ventricular end-diastolic dimension, left atrium dimension) improved after the one-year follow-up, especially in the patients with CRT indications, but also in the bradycardia patients. The independent predictors of a positive heart function response were higher baseline NT-proBNP and the presence of either RBBB or LBBB. The electrical parameters were satisfactory but a slight raise in the pacing threshold was observed at subsequent control visits. Major complications occurred in 4.5% of patients in the acute phase and in 4.4% during the follow-up (the most common was dislodgement of the non-LBBAP lead). One patient is presumed to have developed pacing-induced cardiomyopathy. The most frequent mild complications were intraprocedural RBBB (9.1%) and conversion to deep septal pacing during the follow-up period (5.5%). In addition, 4.4% of the patients required individual programming of the pacing output to maintain the optimal type of capture. Conclusions: The impact of LBBAP device implantation on cardiac function parameters is positive in a wide range of indications, especially in patients with RBBB or LBBB. The prevalence of complications is relatively high but major complications are rarely associated with LBBAP issues.<\/jats:p>","DOI":"10.3390\/jcm13061532","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T04:19:02Z","timestamp":1709785142000},"page":"1532","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Detailed One-Year Follow-Up in Left Bundle Branch Area Pacing: Echocardiography, Natriuretic Peptide, Electrical Parameters and Complications"],"prefix":"10.3390","volume":"13","author":[{"given":"Maciej","family":"Fularz","sequence":"first","affiliation":[{"name":"Department of Cardiology, University of Zielona G\u00f3ra, ul. Zyty 28, 65-046 Zielona G\u00f3ra, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Przemys\u0142aw","family":"Mitkowski","sequence":"additional","affiliation":[{"name":"1st Department of Cardiology, Pozna\u0144 University of Medical Sciences, ul. D\u0142uga 1\/2, 61-848 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s12471-022-01679-7","article-title":"A single-centre prospective evaluation of left bundle branch area pacemaker implantation characteristics","volume":"30","author":"Heckman","year":"2022","journal-title":"Neth. Heart J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.hrthm.2022.04.033","article-title":"Left bundle branch area pacing in patients with atrioventricular conduction disease: A prospective multicenter study","volume":"19","author":"Verma","year":"2022","journal-title":"Heart Rhythm."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/j.jacep.2020.07.004","article-title":"Initial Experience, Safety, and Feasibility of Left Bundle Branch Area Pacing: A Multicenter Prospective Study","volume":"6","author":"Padala","year":"2020","journal-title":"JACC Clin Electrophysiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.33963\/KP.a2023.0157","article-title":"The impact of operator experience on the success rate, time aspects, and electrocardiographic features in left bundle branch area pacing","volume":"81","author":"Fularz","year":"2023","journal-title":"Kardiol. Pol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1093\/eurheartj\/ehac445","article-title":"Left bundle branch area pacing outcomes: The multicentre European MELOS study","volume":"43","author":"Cano","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Heckman, L.I.B., Luermans, J.G.L.M., Curila, K., Van Stipdonk, A.M., Westra, S., Smisek, R., Prinzen, F.W., and Vernooy, K. (2021). Comparing Ventricular Synchrony in Left Bundle Branch and Left Ventricular Septal Pacing in Pacemaker Patients. J. Clin. Med., 10.","DOI":"10.3390\/jcm10040822"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.hrthm.2021.08.033","article-title":"Clinical outcomes of left bundle branch area pacing compared to right ventricular pacing: Results from the Geisinger-Rush Conduction System Pacing Registry","volume":"19","author":"Sharma","year":"2022","journal-title":"Heart Rhythm."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e24185","DOI":"10.1002\/clc.24185","article-title":"Left bundle branch area pacing improving the left atrial outcomes in pace-dependent patients compared with right ventricular outflow tract septal pacing","volume":"47","author":"Zhao","year":"2023","journal-title":"Clin. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/clc.24028","article-title":"Left bundle branch area pacing in mildly reduced heart failure: A systematic literature review and meta-analysis","volume":"46","author":"Yu","year":"2023","journal-title":"Clin. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/pace.14707","article-title":"Left bundle branch area pacing prevents pacing induced cardiomyopathy in long-term observation","volume":"46","author":"Bednarek","year":"2023","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e009261","DOI":"10.1161\/CIRCEP.120.009261","article-title":"Long-Term Safety and Feasibility of Left Bundle Branch Pacing in a Large Single-Center Study","volume":"14","author":"Su","year":"2021","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jacc.2023.05.006","article-title":"Comparison of Left Bundle Branch Area Pacing and Biventricular Pacing in Candidates for Resynchronization Therapy","volume":"82","author":"Vijayaraman","year":"2023","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jacep.2020.08.015","article-title":"Left Bundle Branch Area Pacing for Cardiac Resynchronization Therapy: Results From the International LBBAP Collaborative Study Group","volume":"7","author":"Vijayaraman","year":"2021","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.hroo.2022.05.004","article-title":"Left bundle branch area pacing in patients with heart failure and right bundle branch block: Results from International LBBAP Collaborative-Study Group","volume":"3","author":"Vijayaraman","year":"2022","journal-title":"Heart Rhythm. O2"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1111\/pace.14723","article-title":"The specific value of upgrading to left bundle branch area pacing in patients with pacing-induced cardiomyopathy or non-pacing-induced cardiomyopathy related upgrade status: A retrospective study","volume":"46","author":"Shan","year":"2023","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.hrthm.2021.07.057","article-title":"Left bundle branch-optimized cardiac resynchronization therapy (LOT-CRT): Results from an international LBBAP collaborative study group","volume":"19","author":"Moskal","year":"2022","journal-title":"Heart Rhythm."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cjca.2020.05.011","article-title":"Simplifying Physiological Left Bundle Branch Area Pacing Using a New Nine-Partition Method","volume":"37","author":"Zhang","year":"2021","journal-title":"Can. J. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.hrthm.2020.12.019","article-title":"Fixation beats: A novel marker for reaching the left bundle branch area during deep septal lead implantation","volume":"18","author":"Moskal","year":"2021","journal-title":"Heart Rhythm."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1093\/europace\/euad043","article-title":"EHRA clinical consensus statement on conduction system pacing implantation: Endorsed by the Asia Pacific Heart Rhythm Society (APHRS), Canadian Heart Rhythm Society (CHRS), and Latin American Heart Rhythm Society (LAHRS)","volume":"25","author":"Burri","year":"2023","journal-title":"Europace"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.hrthm.2022.09.019","article-title":"Pacing-induced cardiomyopathy: A systematic review and meta-analysis of definition, prevalence, risk factors, and management","volume":"20","author":"Somma","year":"2023","journal-title":"Heart Rhythm."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/6\/1532\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:10:15Z","timestamp":1760105415000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/6\/1532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,7]]},"references-count":20,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["jcm13061532"],"URL":"https:\/\/doi.org\/10.3390\/jcm13061532","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2024,3,7]]}}}