{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:51:56Z","timestamp":1760143916354,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Pelvic venous obstruction (PVO), defined as greater than 50% stenosis or occlusion of pelvic veins, is a known risk factor for deep vein thrombosis (DVT). DVT is a known risk factor for chronic thromboembolic pulmonary hypertension (CTEPH), but the prevalence of PVO in CTEPH is unknown. Methods: This cross-sectional study at Temple University\u2019s tertiary referral center for Pulmonary Hypertension, Right Heart Failure, and CTEPH sought to identify the presence of PVO in patients with CTEPH who underwent cardiac catheterization, pulmonary angiography, and venography. Results: A total of 193 CTEPH patients were referred for pulmonary angiography, and among these, 148 underwent venography. PVO was identified in 65 (44%) patients. Lower extremity (LE) DVT was associated with PVO (p = 0.004). The severity of pulmonary hypertension was similar with and without PVO (mean pulmonary artery pressure 43.0 \u00b1 10.3 mm Hg vs. 43.8 \u00b1 12.4 mm Hg, p = 0.70), as was the need for pulmonary thromboendarterectomy (69.2% vs. 61.4%, p = 0.32). Conclusions: Pelvic vein obstruction is common and a novel clinical association in patients with CTEPH, particularly in patients with a history of LE DVT. PVO and its role in CTEPH warrants further study, including the potential role of revascularization to mitigate further risk.<\/jats:p>","DOI":"10.3390\/jcm13061553","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T03:52:11Z","timestamp":1709869931000},"page":"1553","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pelvic Vein Obstruction in Chronic Thromboembolic Pulmonary Hypertension: A Novel Association"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6513-4112","authenticated-orcid":false,"given":"Anjali","family":"Vaidya","sequence":"first","affiliation":[{"name":"Pulmonary Hypertension, Right Heart Failure, and CTEPH Program, Division of Cardiovascular Disease, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anika","family":"Vaidy","sequence":"additional","affiliation":[{"name":"Pulmonary Hypertension, Right Heart Failure, and CTEPH Program, Division of Cardiovascular Disease, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Al-Otaibi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0889-3777","authenticated-orcid":false,"given":"Brooke","family":"Zlotshewer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estefania","family":"Oliveros","sequence":"additional","affiliation":[{"name":"Pulmonary Hypertension, Right Heart Failure, and CTEPH Program, Division of Cardiovascular Disease, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Temple University Hospital, Philadelphia, PA 19140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Sadek","sequence":"additional","affiliation":[{"name":"Pulmonary Hypertension, Right Heart Failure, and CTEPH Program, Division of Cardiovascular Disease, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Lakhter","sequence":"additional","affiliation":[{"name":"Pulmonary Hypertension, Right Heart Failure, and CTEPH Program, Division of Cardiovascular Disease, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul R.","family":"Forfia","sequence":"additional","affiliation":[{"name":"Pulmonary Hypertension, Right Heart Failure, and CTEPH Program, Division of Cardiovascular Disease, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riyaz","family":"Bashir","sequence":"additional","affiliation":[{"name":"Pulmonary Hypertension, Right Heart Failure, and CTEPH Program, Division of Cardiovascular Disease, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/14779072.2022.2034499","article-title":"Chronic thromboembolic pulmonary hypertension: A review of risk factors, management and current challenges","volume":"20","author":"Cannon","year":"2022","journal-title":"Expert. 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