{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:52:25Z","timestamp":1783072345111,"version":"3.54.6"},"reference-count":25,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,10]],"date-time":"2024-03-10T00:00:00Z","timestamp":1710028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: An unexplained condition that follows transcatheter aortic valve implantation (TAVI) is platelet count reduction (PR). According to published research, patients with balloon-expandable valves (BEVs) had a greater PR than those with self-expandable valves (SEVs). Objectives: The purpose of this study was to investigate the incidence and clinical effects of PR following TAVI. Methods: In total, 1.122 adult TAVI patients were enrolled. Propensity score matching was carried out in a 1:1 ratio between patients with BEVs and those with SEVs. The analysis included changes in platelet count, in-hospital mortality, and early postoperative adverse events. Results: Notably, 632 patients were matched (BEV:316; SEV:316). All patients\u2019 post-procedural platelet counts changed according to a parabolic curve, using a mixed regression model for repeated analyses (estimate = \u22120.931; standard error = 0.421; p = 0.027). The platelet count varied comparably in patients with BEVs and SEVs (estimate = \u22124.276, standard error = 4.760, p = 0.369). The average time for obtaining the nadir platelet count value was three days after implantation (BEV: 146 (108\u2013181) vs. SEV: 149 (120\u2013186); p = 0.142). Overall, 14.6% of patients (92\/632) had post-procedural platelet count &lt;100,000\/\u00b5L. There was no difference between the two prosthesis types (BEV:51\/316; SEV:41\/316; p = 0.266). Thrombocytopenia was found to be significantly linked to blood product transfusions, lengthier stays in the intensive care unit and hospital, and in-hospital mortality. Conclusions: TAVI, irrespective of the type of implanted valve, is linked to a significant but temporary PR. Thrombocytopenia increases the risk of serious complications and in-hospital death in TAVI patients. To explore and clarify the causes and associated effects, further prospective research is necessary.<\/jats:p>","DOI":"10.3390\/jcm13061579","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T04:51:12Z","timestamp":1710132672000},"page":"1579","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Platelet Reduction after Transcatheter Aortic Valve Implantation: Results from the PORTRAIT Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6889-5686","authenticated-orcid":false,"given":"Federica","family":"Jiritano","sequence":"first","affiliation":[{"name":"Cardiac Surgery Unit, Department of Experimental and Clinical Medicine, University \u201cMagna Graecia\u201d of Catanzaro, 88100 Catanzaro, Italy"},{"name":"Department of Cardio-Thoracic Surgery, Heart & Vascular Centre, Maastricht University Medical Centre (MUMC), Cardiovascular Research Institute Maastricht (CARIM), 6229 Maastricht, The Netherlands"},{"name":"Thoracic Research Centre, Collegium Medicum Nicolaus Copernicus University, Innovative Medical Forum, 85-094 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2611-5626","authenticated-orcid":false,"given":"Michele","family":"Di Mauro","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic Surgery, Heart & Vascular Centre, Maastricht University Medical Centre (MUMC), Cardiovascular Research Institute Maastricht (CARIM), 6229 Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4804-9570","authenticated-orcid":false,"given":"Giuseppe Filiberto","family":"Serraino","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, Department of Experimental and Clinical Medicine, University \u201cMagna Graecia\u201d of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3060-0520","authenticated-orcid":false,"given":"Pasquale","family":"Mastroroberto","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, Department of Experimental and Clinical Medicine, University \u201cMagna Graecia\u201d of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9415-7727","authenticated-orcid":false,"given":"Elena","family":"Caporali","sequence":"additional","affiliation":[{"name":"Cardiac Surgery, Istituto Cardiocentro Ticino, 6900 Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2837-3242","authenticated-orcid":false,"given":"Enrico","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Cardiac Surgery, Istituto Cardiocentro Ticino, 6900 Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5478-3245","authenticated-orcid":false,"given":"Mariusz","family":"Kowalewski","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic Surgery, Heart & Vascular Centre, Maastricht University Medical Centre (MUMC), Cardiovascular Research Institute Maastricht (CARIM), 6229 Maastricht, The Netherlands"},{"name":"Thoracic Research Centre, Collegium Medicum Nicolaus Copernicus University, Innovative Medical Forum, 85-094 Bydgoszcz, Poland"},{"name":"Clinical Department of Cardiac Surgery, Central Clinical Hospital of the Ministry of Interior and Administration, Centre of Postgraduate Medical Education, 01-813 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9902-2864","authenticated-orcid":false,"given":"Roberto","family":"Scrofani","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, Luigi Sacco Hospital, 20157 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Patan\u00e8","sequence":"additional","affiliation":[{"name":"Department of Cardiology Cardiac Surgery (Centro Cuore), Centro Clinico Diagnostico G.B. Morgagni, 95125 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Visicchio","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Santa Maria Hospital, GVM Care & Research, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2261-7098","authenticated-orcid":false,"given":"Domenico","family":"Paparella","sequence":"additional","affiliation":[{"name":"Dipartimento Scienze Mediche e Chirurgiche, Universit\u00e0 di Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giosu\u00e8","family":"Falcetta","sequence":"additional","affiliation":[{"name":"University Hospital\u2014Section of Cardiac Surgery, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Colli","sequence":"additional","affiliation":[{"name":"University Hospital\u2014Section of Cardiac Surgery, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Matteucci","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic Surgery, Heart & Vascular Centre, Maastricht University Medical Centre (MUMC), Cardiovascular Research Institute Maastricht (CARIM), 6229 Maastricht, The Netherlands"},{"name":"Thoracic Research Centre, Collegium Medicum Nicolaus Copernicus University, Innovative Medical Forum, 85-094 Bydgoszcz, Poland"},{"name":"Department of Surgical and Morphological Sciences, Circolo Hospital, University of Insubria, 21100 Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giangiuseppe","family":"Cappabianca","sequence":"additional","affiliation":[{"name":"Department of Surgical and Morphological Sciences, Circolo Hospital, University of Insubria, 21100 Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1729-532X","authenticated-orcid":false,"given":"Francesco","family":"Pollari","sequence":"additional","affiliation":[{"name":"Klinikum N\u00fcrnberg, Cardiovascular Center, Paracelsus Medical University, 90419 Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodor","family":"Fischlein","sequence":"additional","affiliation":[{"name":"Klinikum N\u00fcrnberg, Cardiovascular Center, Paracelsus Medical University, 90419 Nuremberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Lorusso","sequence":"additional","affiliation":[{"name":"Department of Cardio-Thoracic Surgery, Heart & Vascular Centre, Maastricht University Medical Centre (MUMC), Cardiovascular Research Institute Maastricht (CARIM), 6229 Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,10]]},"reference":[{"key":"ref_1","unstructured":"Writing Committee Members, Otto, C.M., Nishimura, R.A., Bonow, R.O., Carabello, B.A., Erwin, J.P., Gentile, F., Jneid, H., Krieger, E.V., and Mack, M. (2021). 2020 ACC\/AHA guideline for the management of patients with valvular heart disease: A report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. J. Thorac. Cardiovasc. Surg., 162, e183\u2013e353."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"ESC\/EACTS Scientific Document Group. 2021 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"43","author":"Vahanian","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e1826","DOI":"10.4244\/EIJ-D-18-01048","article-title":"The evolution of device technology in transcatheter aortic valve implantation","volume":"14","author":"Bourantas","year":"2019","journal-title":"EuroIntervention"},{"key":"ref_4","first-page":"e201632","article-title":"The development of transcatheter aortic valve replacement (TAVR)","volume":"2016","author":"Cribier","year":"2017","journal-title":"Glob. Cardiol. Sci. Pr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ijcard.2019.07.056","article-title":"Peri-procedural thrombocytopenia after aortic bioprosthesis implant: A sys-tematic review and meta-analysis comparison among conventional, stentless, rapid-deployment, and transcatheter valves","volume":"296","author":"Jiritano","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.advms.2017.04.003","article-title":"Thrombocytopenia associated with TAVI\u2014The summary of possible causes","volume":"62","author":"Mitrosz","year":"2017","journal-title":"Adv. Med. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.amjcard.2018.12.036","article-title":"Comparison of the Frequency of Thrombocytopenia After Transfemoral Transcatheter Aortic Valve Implantation Between Balloon-Expandable and Self-Expanding Valves","volume":"123","author":"Chollet","year":"2019","journal-title":"Am. J. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1093\/eurheartj\/ehu082","article-title":"Acquired thrombocytopenia after transcatheter aortic valve replacement: Clinical correlates and association with outcomes","volume":"35","author":"Dvir","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_9","first-page":"44","article-title":"Thrombocytopenia in Adults: Review Article","volume":"1","author":"Erkurt","year":"2012","journal-title":"J. Hematol."},{"key":"ref_10","first-page":"e27718","article-title":"A Comprehensive Review of Thrombocytopenia With a Spotlight on Intensive Care Patients","volume":"14","author":"Santoshi","year":"2022","journal-title":"Cureus"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"VARC-3 WRITING COMMITTEE, G\u00e9n\u00e9reux, P., Piazza, N., Alu, M.C., Nazif, T., Hahn, R.T., Pibarot, P., Bax, J.J., Leipsic, J.A., and Blanke, P. (2021). Valve Academic Research Consortium 3: Updated endpoint definitions for aortic valve clinical research. Eur. Heart J., 42, 1825\u20131857.","DOI":"10.1093\/eurheartj\/ehaa799"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1093\/ejcts\/ezab175","article-title":"Perioperative platelet reduction after sutureless or stented valve implantation: Results from the PERSIST-AVR controlled randomized trial","volume":"60","author":"Lorusso","year":"2021","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1111\/jocs.14547","article-title":"Two approaches\u2014One phenomenon\u2014Thrombocytopenia after surgical and transcatheter aortic valve replacement","volume":"35","author":"Vogt","year":"2020","journal-title":"J. Card. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13104-020-05386-7","article-title":"Predictors of short-term thrombocytopenia after transcatheter aortic valve implantation: A retrospective study at a single Japanese center","volume":"13","author":"Yamada","year":"2020","journal-title":"BMC Res. Notes"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/aor.12606","article-title":"Paradoxical Effect of Nonphysiological Shear Stress on Platelets and von Willebrand Factor","volume":"40","author":"Chen","year":"2015","journal-title":"Artif. Organs"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1510\/icvts.2007.169326","article-title":"Thrombocytopenia after aortic valve replacement with the Freedom Solo stentless bioprosthesis","volume":"7","author":"Yerebakan","year":"2008","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1007\/s12265-021-10117-9","article-title":"Thrombocytopenia Complicating Transcatheter Aortic Valve Implantation: Differences Between Two New-Generation Devices","volume":"14","author":"Corcione","year":"2021","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.amjcard.2013.01.332","article-title":"Effect of transcatheter (via femoral artery) aortic valve implantation on the platelet count and its consequences","volume":"111","author":"Gallet","year":"2013","journal-title":"Am. J. Cardiol."},{"key":"ref_19","first-page":"e1","article-title":"Severe thrombocytopenia induced by iodinated contrast after coronary angiography: The use of gadolinium contrast and intravascular ultrasound as an alternative to guide percutaneous coronary intervention","volume":"36","year":"2017","journal-title":"Rev. Port. Cardiol."},{"key":"ref_20","first-page":"24","article-title":"Feasibility of ultra-low contrast 64-slice computed tomography angiography before transcatheter aortic valve implantation: A real-world experience","volume":"17","author":"Spagnolo","year":"2016","journal-title":"Eur. Heart J. -Cardiovasc. Imaging"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Abu Khadija, H., Gandelman, G., Ayyad, O., Jaber, M., Poles, L., Jonas, M., Paz, O., Abu Sbaih, F., Sella, G., and Shimoni, S. (2021). Differential systemic inflammatory responses after TAVI: The role of self versus balloon expandable devices. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0258963"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/ccd.25430","article-title":"Major thrombocytopenia after balloon-expandable transcatheter aortic valve replacement: Prognostic implications and comparison to surgical aortic valve replacement","volume":"85","author":"Jilaihawi","year":"2015","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/ccd.25206","article-title":"Incidence and implications of idiopathic thrombocytopenia following transcatheter aortic valve replacement with the Edwards Sapien\u00a9 valves: A single center experience","volume":"83","author":"McCabe","year":"2014","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/ccd.25668","article-title":"Predictors and clinical impact of pre-existing and acquired thrombocytopenia following transcatheter aortic valve replacement","volume":"85","author":"Flaherty","year":"2015","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1080\/14779072.2021.1924678","article-title":"Trends, predictors, and outcomes of major bleeding after transcatheter aortic valve implantation, from national inpatient sample (2011\u20132018)","volume":"19","author":"Zahid","year":"2021","journal-title":"Expert Rev. Cardiovasc. Ther."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/6\/1579\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:11:30Z","timestamp":1760105490000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/6\/1579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,10]]},"references-count":25,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["jcm13061579"],"URL":"https:\/\/doi.org\/10.3390\/jcm13061579","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,10]]}}}