{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:40:31Z","timestamp":1793947231258,"version":"4.8.0"},"reference-count":90,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,10]],"date-time":"2024-03-10T00:00:00Z","timestamp":1710028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: In recent years, a global epidemiological shift in candidemia has been observed, marked by the emergence of resistant non-albicans Candida species. Candida auris, in particular, has become a significant global concern, causing infections in both pediatric and adult populations within healthcare settings. Despite its widespread impact, there is a limited understanding of the clinical course and transmission dynamics of neonatal systemic Candida auris infections, hindering effective prevention and management. This study focused on the epidemiologic data, the clinical presentation, risk factors, and outcome of C. auris infection in neonatal population. (2) Methods: A systematic review of the literature using PubMed and Scopus databases until December 2023 was conducted. (3) Results: A total of 24 relevant studies were identified, encompassing 476 documented cases of Candida auris infection in neonates. Prematurity emerged as a primary risk factor, alongside total parenteral nutrition, central line insertion, mechanical ventilation, and prior broad-spectrum antibiotic use. The mortality rate reached approximately 42%, with therapeutic details sparingly reported in 12% of cases. Treatment strategies varied, with amphotericin B predominantly used as monotherapy, while combination antifungal agents were used in 44% of cases. Notably, 97.4% of cases exhibited fluconazole resistance, and 67.1% showed resistance to amphotericin B. Limited data were available on resistance to other antifungal agents. (4) Conclusions: Despite the rarity of neonatal Candida auris infections, their global occurrence necessitates comprehensive preparedness in patient care. A deeper understanding of Candida auris pathogenesis is crucial for developing effective strategies to control and prevent neonatal infections caused by this pathogen.<\/jats:p>","DOI":"10.3390\/jcm13061586","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T04:51:12Z","timestamp":1710132672000},"page":"1586","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Candida auris Infection, a Rapidly Emerging Threat in the Neonatal Intensive Care Units: A Systematic Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9972-8901","authenticated-orcid":false,"given":"Rozeta","family":"Sokou","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit, \u201cAgios Panteleimon\u201d General Hospital of Nikea, 18454 Piraeus, Greece"},{"name":"Neonatal Department, National and Kapodistrian University of Athens, Aretaieio Hospital, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexia Eleftheria","family":"Palioura","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, \u201cAgios Panteleimon\u201d General Hospital of Nikea, 18454 Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4978-2539","authenticated-orcid":false,"given":"Paschalia","family":"Kopanou Taliaka","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, \u201cAgios Panteleimon\u201d General Hospital of Nikea, 18454 Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4966-6826","authenticated-orcid":false,"given":"Aikaterini","family":"Konstantinidi","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, \u201cAgios Panteleimon\u201d General Hospital of Nikea, 18454 Piraeus, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3695-0759","authenticated-orcid":false,"given":"Andreas G.","family":"Tsantes","sequence":"additional","affiliation":[{"name":"Microbiology Department, \u201cSaint Savvas\u201d Oncology Hospital, 11522 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1414-6639","authenticated-orcid":false,"given":"Daniele","family":"Piovani","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 Milan, Italy"},{"name":"IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina A.","family":"Tsante","sequence":"additional","affiliation":[{"name":"Laboratory of Haematology and Blood Bank Unit, \u201cAttiko\u201d Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni A.","family":"Gounari","sequence":"additional","affiliation":[{"name":"East Sussex Hospitals NHS Trust, Hastings TN37 7PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4316-7305","authenticated-orcid":false,"given":"Zoi","family":"Iliodromiti","sequence":"additional","affiliation":[{"name":"Neonatal Department, National and Kapodistrian University of Athens, Aretaieio Hospital, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora","family":"Boutsikou","sequence":"additional","affiliation":[{"name":"Neonatal Department, National and Kapodistrian University of Athens, Aretaieio Hospital, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argirios E.","family":"Tsantes","sequence":"additional","affiliation":[{"name":"Laboratory of Haematology and Blood Bank Unit, \u201cAttiko\u201d Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6102-6579","authenticated-orcid":false,"given":"Stefanos","family":"Bonovas","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 Milan, Italy"},{"name":"IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8021-6191","authenticated-orcid":false,"given":"Nicoletta","family":"Iacovidou","sequence":"additional","affiliation":[{"name":"Neonatal Department, National and Kapodistrian University of Athens, Aretaieio Hospital, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e01588-17","DOI":"10.1128\/JCM.01588-17","article-title":"Candida auris: An emerging fungal pathogen","volume":"56","author":"Spivak","year":"2018","journal-title":"J. Clin. Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.2174\/1389450120666190924155631","article-title":"Candida auris and Nosocomial Infection","volume":"21","author":"Dahiya","year":"2020","journal-title":"Curr. Drug Targets"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Sabino, R., Ver\u00edssimo, C., Pereira, \u00c1.A., and Antunes, F. (2020). Candida auris, an agent of hospital-associated outbreaks: Which challenging issues do we need to have in mind?. Microorganisms, 8.","DOI":"10.3390\/microorganisms8020181"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Hu, S., Zhu, F., Jiang, W., Wang, Y., Quan, Y., Zhang, G., Gu, F., and Yang, Y. (2021). Retrospective Analysis of the Clinical Characteristics of Candida auris Infection Worldwide From 2009 to 2020. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.658329"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Chen, J., Tian, S., Han, X., Chu, Y., Wang, Q., Zhou, B., and Shang, H. (2020). Is the superbug fungus really so scary? A systematic review and meta-analysis of global epidemiology and mortality of Candida auris. BMC Infect. Dis., 20.","DOI":"10.1186\/s12879-020-05543-0"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.15698\/mic2022.08.782","article-title":"The rise of Candida auris: From unique traits to co-infection potential","volume":"9","author":"Egger","year":"2022","journal-title":"Microb. Cell"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Cristina, M.L., Spagnolo, A.M., Sartini, M., Carbone, A., Oliva, M., Schinca, E., Boni, S., and Pontali, E. (2023). An Overview on Candida auris in Healthcare Settings. J. Fungi, 9.","DOI":"10.3390\/jof9090913"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1348-0421.2008.00083.x","article-title":"Candida auris sp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital","volume":"53","author":"Satoh","year":"2009","journal-title":"Microbiol. Immunol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1086\/597108","article-title":"Candida haemulonii and closely related species at 5 university hospitals in Korea: Identification, antifungal susceptibility, and clinical features","volume":"48","author":"Kim","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1128\/JCM.00319-11","article-title":"First three reported cases of nosocomial fungemia caused by Candida auris","volume":"49","author":"Lee","year":"2011","journal-title":"J. Clin. Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Garcia-Bustos, V., Cabanero-Navalon, M.D., Ruiz-Saur\u00ed, A., Ruiz-Gait\u00e1n, A.C., Salavert, M., Tormo, M.\u00c1., and Pem\u00e1n, J. (2021). What Do We Know about Candida auris? State of the Art, Knowledge Gaps, and Future Directions. Microorganisms, 9.","DOI":"10.1128\/Spectrum.00013-21"},{"key":"ref_12","unstructured":"CDC (2024, January 29). Antibiotic Resistance Threats in the United States, Available online: www.cdc.gov\/DrugResistance\/Biggest-Threats.html."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e396","DOI":"10.1016\/S2666-5247(23)00143-X","article-title":"Emergence of resistant Candida auris","volume":"4","author":"Nelson","year":"2023","journal-title":"Lancet Microbe"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.cmi.2020.12.030","article-title":"Outbreak of Candida auris infection in a COVID-19 hospital in Mexico","volume":"27","year":"2021","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.3201\/eid2611.203504","article-title":"Multidrug-Resistant Candida auris Infections in Critically Ill Coronavirus Disease Patients, India, April\u2013July 2020","volume":"26","author":"Chowdhary","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1093\/mmy\/myab057","article-title":"C. auris and non-C. auris candidemia in hospitalized adult and pediatric COVID-19 patients; single center data from Pakistan","volume":"59","author":"Moin","year":"2021","journal-title":"Med. Mycol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"de Almeida, J.N., Francisco, E.C., Hagen, F., Brand\u00e3o, I.B., Pereira, F.M., Presta Dias, P.H., de Miranda Costa, M.M., de Souza Jord\u00e3o, R.T., de Groot, T., and Colombo, A.L. (2021). Emergence of Candida auris in Brazil in a COVID-19 Intensive Care Unit. J. Fungi, 7.","DOI":"10.3390\/jof7030220"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"56","DOI":"10.15585\/mmwr.mm7002e3","article-title":"Candida auris Outbreak in a COVID-19 Specialty Care Unit\u2014Florida, July\u2013August 2020","volume":"70","author":"Prestel","year":"2021","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"105285","DOI":"10.1016\/j.micpath.2021.105285","article-title":"Dissemination of Candida auris to deep organs in neonatal murine invasive candidiasis","volume":"161","author":"Andrade","year":"2021","journal-title":"Microb. Pathog."},{"key":"ref_20","first-page":"276","article-title":"Candida auris: Outbreak fungal pathogen in COVID-19 pandemic: A systematic review and meta-analysis","volume":"14","author":"Akbari","year":"2022","journal-title":"Iran. J. Microbiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/INF.0000000000002530","article-title":"Etiology and Outcome of Candidemia in Neonates and Children in Europe: An 11-year Multinational Retrospective Study","volume":"39","author":"Warris","year":"2020","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Noni, M., Stathi, A., Vaki, I., Velegraki, A., Zachariadou, L., and Michos, A. (2019). Changing epidemiology of invasive candidiasis in children during a 10-year period. J. Fungi, 5.","DOI":"10.3390\/jof5010019"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/jpids\/piaa152","article-title":"A Cluster of Neonatal Infections Caused by Candida auris at a Large Referral Center in Colombia","volume":"10","year":"2021","journal-title":"J. Pediatr. Infect. Dis. Soc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.3201\/eid2507.180491","article-title":"Hospital-associated multicenter outbreak of emerging fungus Candida auris, colombia, 2016","volume":"25","author":"Armstrong","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.3201\/eid2509.190040","article-title":"Epidemiologic shift in Candidemia driven by Candida auris, South Africa, 2016\u20132017","volume":"25","author":"Mpembe","year":"2019","journal-title":"Emerg. Infect. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Kopanou Taliaka, P., Tsantes, A.G., Konstantinidi, A., Houhoula, D., Tsante, K.A., Vaiopoulos, A.G., Piovani, D., Nikolopoulos, G.K., Bonovas, S., and Iacovidou, N. (2023). Risk Factors, Diagnosis, and Treatment of Neonatal Fungal Liver Abscess: A Systematic Review of the Literature. Life, 13.","DOI":"10.3390\/life13010167"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/1469-0691.12040","article-title":"ESCMID* guideline for the diagnosis and management of Candida diseases 2012: Prevention and management of invasive infections in neonates and children caused by Candida spp.","volume":"18","author":"Hope","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/myc.12792","article-title":"Candidemia in children: Epidemiology, prevention and management","volume":"61","author":"Mantadakis","year":"2018","journal-title":"Mycoses"},{"key":"ref_29","first-page":"28","article-title":"Invasive candidiasis and candidemia in pediatric and neonatal patients: A review of current guidelines","volume":"4","author":"Vasileiou","year":"2018","journal-title":"Curr. Med. Mycol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Hsu, J.F., Lai, M.Y., Lee, C.W., Chu, S.M., Wu, I.H., Huang, H.R., Lee, I.T., Chiang, M.C., Fu, R.H., and Tsai, M.H. (2018). Comparison of the incidence, clinical features and outcomes of invasive candidiasis in children and neonates. BMC Infect. Dis., 18.","DOI":"10.1186\/s12879-018-3100-2"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Bhattacharya, S., Sae-Tia, S., and Fries, B.C. (2020). Candidiasis and mechanisms of antifungal resistance. Antibiotics, 9.","DOI":"10.3390\/antibiotics9060312"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1111\/jpc.15019","article-title":"Neonatal Candida auris infection: Management and prevention strategies\u2014A single centre experience","volume":"56","author":"Chandramati","year":"2020","journal-title":"J. Paediatr. Child Health"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1136\/archdischild-2017-313960","article-title":"Candida auris, what do paediatricians need to know?","volume":"103","author":"Adilia","year":"2018","journal-title":"Arch. Dis. Child."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.jclinepi.2009.06.005","article-title":"Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement","volume":"62","author":"Moher","year":"2009","journal-title":"J. Clin. Epidemiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.3201\/eid1910.130393","article-title":"New clonal strain of Candida auris, Delhi, India","volume":"19","author":"Chowdhary","year":"2013","journal-title":"Emerg. Infect. Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jinf.2016.07.008","article-title":"First report of Candida auris in America: Clinical and microbiological aspects of 18 episodes of candidemia","volume":"73","author":"Calvo","year":"2016","journal-title":"J. Infect."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/cid\/ciw691","article-title":"Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses","volume":"64","author":"Lockhart","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1093\/jac\/dkx034","article-title":"Candida auris candidaemia in Indian ICUs: Analysis of risk factors","volume":"72","author":"Rudramurthy","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jinf.2018.09.002","article-title":"Emergency of fungemia cases caused by fluconazole-resistant Candida auris in Beijing, China","volume":"77","author":"Chen","year":"2018","journal-title":"J. Infect."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3329\/imcjms.v13i2.45276","article-title":"Detection of Candida auris and its antifungal susceptibility: First report from Bangladesh","volume":"13","author":"Dutta","year":"2019","journal-title":"IMC J. Med. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1111\/myc.13145","article-title":"Characteristics, outcome and risk factors for mortality of paediatric patients with ICU-acquired candidemia in India: A multicentre prospective study","volume":"63","author":"Chakrabarti","year":"2020","journal-title":"Mycoses"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/jpids\/piaa038","article-title":"Bloodstream Infections With Candida auris Among Children in Colombia: Clinical Characteristics and Outcomes of 34 Cases","volume":"10","author":"Berrio","year":"2021","journal-title":"J. Pediatr. Infect. Dis. Soc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s00383-021-04881-7","article-title":"Neonatal surgical outcomes: A prospective observational study at a Tertiary Academic Hospital in Johannesburg, South Africa","volume":"37","author":"Withers","year":"2021","journal-title":"Pediatr. Surg. Int."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ijmmb.2021.03.025","article-title":"Candida auris, an emerging pathogen\u2014Challenge in the survival of microprimies","volume":"39","author":"Ramya","year":"2021","journal-title":"Indian J. Med. Microbiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"58","DOI":"10.4103\/jms.jms_28_21","article-title":"Clinicomycological study of Candida isolates in a tertiary care hospital: A pilot study","volume":"35","author":"Mishra","year":"2021","journal-title":"J. Med. Soc."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1097\/INF.0000000000003151","article-title":"Epidemiology of Culture-confirmed Candidemia Among Hospitalized Children in South Africa, 2012\u20132017","volume":"40","author":"Shuping","year":"2021","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_47","first-page":"326","article-title":"Incidence of candidemia and prevalence of azole-resistant candidemia at a tertiary South African hospital\u2014A retrospective laboratory analysis 2016\u20132020","volume":"37","author":"Chibabhai","year":"2022","journal-title":"S. Afr. J. Infect. Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"e1170","DOI":"10.1016\/S2214-109X(22)00246-7","article-title":"Culture-confirmed neonatal bloodstream infections and meningitis in South Africa, 2014-19: A cross-sectional study","volume":"10","author":"Mashau","year":"2022","journal-title":"Lancet Glob. Health"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Sathi, F.A., Paul, S.K., Ahmed, S., Alam, M.M., Nasreen, S.A., Haque, N., Islam, A., Nila, S.S., Afrin, S.Z., and Aung, M.S. (2022). Prevalence and Antifungal Susceptibility of Clinically Relevant Candida Species, Identification of Candida auris and Kodamaea ohmeri in Bangladesh. Trop. Med. Infect. Dis., 7.","DOI":"10.3390\/tropicalmed7090211"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"myad010","DOI":"10.1093\/mmy\/myad010","article-title":"Neonatal invasive candidiasis in low- and middle-income countries: Data from the NeoOBS study","volume":"61","author":"Cook","year":"2023","journal-title":"Med. Mycol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Sathi, F.A., Aung, M.S., Paul, S.K., Nasreen, S.A., Haque, N., Roy, S., Ahmed, S., Alam, M.M., Khan, S., and Rabbany, M.A. (2023). Clonal Diversity of Candida auris, Candida blankii, and Kodamaea ohmeri Isolated from Septicemia and Otomycosis in Bangladesh as Determined by Multilocus Sequence Typing. J. Fungi, 9.","DOI":"10.3390\/jof9060658"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1007\/s12098-023-04672-z","article-title":"Candida auris as the Predominant Species Causing Invasive Candidiasis in Neonates and Children","volume":"90","author":"Singhal","year":"2023","journal-title":"Indian J. Pediatr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.3201\/eid2909.230393","article-title":"High Prevalence of Candida auris Colonization during Protracted Neonatal Unit Outbreak, South Africa","volume":"29","author":"Shuping","year":"2023","journal-title":"Emerg. Infect. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"101247","DOI":"10.1016\/j.cegh.2023.101247","article-title":"Epidemiology, risk factors and outcomes associated with candidaemia in very low birth weight infants at a tertiary South African Hospital over a 7-year period (2013\u20132019)","volume":"20","author":"Ramdin","year":"2023","journal-title":"Clin. Epidemiol. Glob. Health"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1542\/peds.110.2.285","article-title":"Late-onset sepsis in very low birth weight neonates: The experience of the NICHD Neonatal Research Network","volume":"110","author":"Stoll","year":"2002","journal-title":"Pediatrics"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41390-021-01842-7","article-title":"Invasive fungal infections in neonates: A review","volume":"91","author":"Weimer","year":"2022","journal-title":"Pediatr. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.clp.2014.10.008","article-title":"The epidemiology and diagnosis of invasive candidiasis among premature infants","volume":"42","author":"Kelly","year":"2015","journal-title":"Clin. Perinatol."},{"key":"ref_58","first-page":"195","article-title":"Multidrug-resistant Candida haemulonii and C. auris, tel aviv, Israel","volume":"23","author":"Berman","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1146\/annurev-micro-032521-015858","article-title":"Candida auris Genetics and Emergence","volume":"77","author":"Chowdhary","year":"2023","journal-title":"Annu. Rev. Microbiol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Ashkenazi-Hoffnung, L., and Rosenberg Danziger, C. (2023). Navigating the New Reality: A Review of the Epidemiological, Clinical, and Microbiological Characteristics of Candida auris, with a Focus on Children. J. Fungi, 9.","DOI":"10.3390\/jof9020176"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jiph.2023.11.021","article-title":"Risk factors, antifungal susceptibility, complications, and outcome of Candida auris bloodstream infection in a tertiary care center in the western region of Saudi Arabia","volume":"17","author":"Munshi","year":"2024","journal-title":"J. Infect. Public Health"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/myc.13447","article-title":"Prevalence, risk factors, treatment and outcome of multidrug resistance Candida auris infections in Coronavirus disease (COVID-19) patients: A systematic review","volume":"65","author":"Vinayagamoorthy","year":"2022","journal-title":"Mycoses"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Horton, M.V., Holt, A.M., and Nett, J.E. (2023). Mechanisms of pathogenicity for the emerging fungus Candida auris. PLoS Pathog., 19.","DOI":"10.1371\/journal.ppat.1011843"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1126\/science.adf8972","article-title":"A Candida auris-specific adhesin, Scf1, governs surface association, colonization, and virulence","volume":"381","author":"Santana","year":"2023","journal-title":"Science"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/myc.12754","article-title":"Comparative virulence of Candida auris with Candida haemulonii, Candida glabrata and Candida albicans in a murine model","volume":"61","author":"Fakhim","year":"2018","journal-title":"Mycoses"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e01625-19","DOI":"10.1128\/AAC.01625-19","article-title":"Impact of Candida auris Infection in a Neutropenic Murine Model","volume":"64","author":"Torres","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"313","DOI":"10.2174\/1389203720666190722152415","article-title":"Virulence Factors in Candida species","volume":"21","author":"Staniszewska","year":"2020","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.cmi.2019.03.028","article-title":"Resistance of Candida to azoles and echinocandins worldwide","volume":"25","author":"Pristov","year":"2019","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"783","DOI":"10.2147\/IDR.S197531","article-title":"Differential recognition of Candida tropicalis, Candida guilliermondii, Candida krusei, and Candida auris by human innate immune cells","volume":"12","author":"Franco","year":"2019","journal-title":"Infect. Drug Resist."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/nri3897","article-title":"Immune defence against Candida fungal infections","volume":"15","author":"Netea","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1038\/s41564-020-0780-3","article-title":"Transcriptional and functional insights into the host immune response against the emerging fungal pathogen Candida auris","volume":"5","author":"Bruno","year":"2020","journal-title":"Nat. Microbiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s40560-018-0342-4","article-title":"Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris","volume":"6","author":"Cortegiani","year":"2018","journal-title":"J. Intensive Care"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s12281-021-00420-y","article-title":"Candida auris: Diagnostic Challenges and Emerging Opportunities for the Clinical Microbiology Laboratory","volume":"15","author":"Keighley","year":"2021","journal-title":"Curr. Fungal Infect. Rep."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e00591-18","DOI":"10.1128\/JCM.00591-18","article-title":"Rapid detection of Candida auris based on loop-mediated isothermal amplification (LAMP)","volume":"56","author":"Yamamoto","year":"2018","journal-title":"J. Clin. Microbiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/myc.12817","article-title":"Evaluation of a new T2 Magnetic Resonance assay for rapid detection of emergent fungal pathogen Candida auris on clinical skin swab samples","volume":"61","author":"Sexton","year":"2018","journal-title":"Mycoses"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s40121-022-00625-9","article-title":"Candida auris candidemia in critically ill, colonized patients: Cumulative incidence and risk factors","volume":"11","author":"Briano","year":"2022","journal-title":"Infect. Dis. Ther."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"myac008","DOI":"10.1093\/mmy\/myac008","article-title":"Emerging and future strategies in the management of recalcitrant Candida auris","volume":"60","author":"Bandara","year":"2022","journal-title":"Med. Mycol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"6","DOI":"10.15585\/mmwr.mm6901a2","article-title":"Candida auris isolates resistant to three classes of antifungal medications\u2014New York, 2019","volume":"69","author":"Ostrowsky","year":"2020","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e0224221","DOI":"10.1128\/aac.02242-21","article-title":"Antifungal Resistance Trends of Candida auris Clinical Isolates in New York and New Jersey from 2016 to 2020","volume":"66","author":"Kilburn","year":"2022","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"726769","DOI":"10.3389\/fped.2021.726769","article-title":"Prophylactic Use of Fluconazole in Very Premature Infants","volume":"9","author":"Zhang","year":"2021","journal-title":"Front. Pediatr."},{"key":"ref_81","unstructured":"CDC (2023, December 30). Treatment and Management of Infections and Colonization|Candida auris|Fungal Diseases|CDC, Available online: https:\/\/www.cdc.gov\/fungal\/candida-auris\/c-auris-treatment.html."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1256688","DOI":"10.1126\/science.1256688","article-title":"Global diversity and geography of soil fungi","volume":"346","author":"Tedersoo","year":"2014","journal-title":"Science"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/myc.12781","article-title":"An outbreak due to Candida auris with prolonged colonisation and 381 candidaemia in a tertiary care European hospital","volume":"61","author":"Moret","year":"2018","journal-title":"Mycoses"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e193","DOI":"10.1016\/S2666-5247(20)30090-2","article-title":"Pan-resistant Candida auris: New York subcluster susceptible to antifungal combinations","volume":"1","author":"Liang","year":"2020","journal-title":"Lancet Microbe"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e314","DOI":"10.1016\/S2666-5247(20)30194-4","article-title":"Micafungin and amphotericin B synergy against Candida auris","volume":"1","author":"Jaggavarapu","year":"2020","journal-title":"Lancet Microbe"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e02195-19","DOI":"10.1128\/AAC.02195-19","article-title":"In vitro evaluation of antifungal drug combinations against multidrug-resistant Candida auris isolates from New York outbreak","volume":"64","author":"Chaturvedi","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Mesini, A., Saffioti, C., Mariani, M., Florio, A., Medici, C., Moscatelli, A., and Castagnola, E. (2021). First case of Candida auris colonization in a preterm, extremely low-birth-weight newborn after vaginal delivery. J. Fungi, 7.","DOI":"10.3390\/jof7080649"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/ped.12157","article-title":"Micafungin versus fluconazole for prophylaxis against fungal infections in premature infants","volume":"55","author":"Maede","year":"2013","journal-title":"Pediatr. Int."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1080\/14656566.2022.2147824","article-title":"An overview of micafungin as a treatment option for invasive candidiasis in pediatric patients younger than 4 months old","volume":"23","author":"Bassetti","year":"2022","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1517\/14740338.2011.545345","article-title":"Safety of micafungin in infants: Insights into optimal dosing","volume":"10","author":"Ascher","year":"2011","journal-title":"Expert Opin. Drug Saf."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/6\/1586\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:11:40Z","timestamp":1760105500000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/6\/1586"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,10]]},"references-count":90,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["jcm13061586"],"URL":"https:\/\/doi.org\/10.3390\/jcm13061586","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,10]]}}}