{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:14:24Z","timestamp":1778822064542,"version":"3.51.4"},"reference-count":30,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,10]],"date-time":"2024-03-10T00:00:00Z","timestamp":1710028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The pretreatment CT perfusion (CTP) marker the relative cerebral blood volume (rCBV) &lt; 42% lesion volume has recently been shown to predict 90-day functional outcomes; however, studies assessing correlations of the rCBV &lt; 42% lesion volume with other outcomes remain sparse. Here, we aim to assess the relationship between the rCBV &lt; 42% lesion volume and the reference standard digital subtraction angiography (DSA)-derived American Society of Interventional and Therapeutic Neuroradiology\/Society of Interventional Radiology (ASITN) collateral score, hereby referred as the DSA CS. Methods: In this retrospective evaluation of our prospectively collected database, we included acute stroke patients triaged by multimodal CT imaging, including CT angiography and perfusion imaging, with confirmed anterior circulation large vessel occlusion between 1 September 2017 and 1 October 2023. Group differences were assessed using the Student\u2019s t test, Mann\u2013Whitney U test and Chi-Square test. Spearman\u2019s rank correlation and logistic regression analyses were used to assess associations between rCBV &lt; 42% and DSA CS. Results: In total, 222 patients (median age: 69 years, 56.3% female) met our inclusion criteria. In the multivariable logistic regression analysis, taking into account age, sex, race, hypertension, hyperlipidemia, diabetes, atrial fibrillation, prior stroke or transient ischemic attack, the admission National Institute of Health stroke scale, the premorbid modified Rankin score, the Alberta stroke program early CT score (ASPECTS), and segment occlusion, the rCBV &lt; 42% lesion volume (adjusted OR: 0.98, p &lt; 0.05) was independently associated with the DSA CS. Conclusion: The rCBV &lt; 42% lesion volume is independently associated with the DSA CS.<\/jats:p>","DOI":"10.3390\/jcm13061588","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T04:51:12Z","timestamp":1710132672000},"page":"1588","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Relative Cerebral Blood Volume (rCBV) &lt; 42% Is Independently Associated with Collateral Status in Anterior Circulation Large Vessel Occlusion"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7577-1887","authenticated-orcid":false,"given":"Dhairya A.","family":"Lakhani","sequence":"first","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3592-708X","authenticated-orcid":false,"given":"Aneri B.","family":"Balar","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manisha","family":"Koneru","sequence":"additional","affiliation":[{"name":"Cooper Medical School, Rowan University, Camden, NJ 08103, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sijin","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, West Virginia University, Morgantown, WV 26506, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8769-3342","authenticated-orcid":false,"given":"Burak Berksu","family":"Ozkara","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanzhang","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3442-0559","authenticated-orcid":false,"given":"Richard","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4051-2946","authenticated-orcid":false,"given":"Meisam","family":"Hoseinyazdi","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehreen","family":"Nabi","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ishan","family":"Mazumdar","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadra","family":"Sepehri","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan","family":"Hyson","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Urrutia","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Licia","family":"Luna","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Argye E.","family":"Hillis","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1055-8000","authenticated-orcid":false,"given":"Jeremy J.","family":"Heit","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stanford University, Stanford, CA 94305, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0263-4632","authenticated-orcid":false,"given":"Greg W.","family":"Albers","sequence":"additional","affiliation":[{"name":"Department of Neurology, Stanford University, Stanford, CA 94305, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ansaar T.","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, West Virginia University, Morgantown, WV 26506, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-5699","authenticated-orcid":false,"given":"Adam A.","family":"Dmytriw","sequence":"additional","affiliation":[{"name":"Department of Radiology, Harvarvd Medical School, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1631-2020","authenticated-orcid":false,"given":"Tobias","family":"Faizy","sequence":"additional","affiliation":[{"name":"Department of Radiology, Neuroendovascular Division, University Medical Center M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Wintermark","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, MD Anderson Medical Center, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4194-9488","authenticated-orcid":false,"given":"Kambiz","family":"Nael","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2450-4014","authenticated-orcid":false,"given":"Vivek S.","family":"Yedavalli","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD 21218, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00234-002-0881-0","article-title":"Collateral circulation is an independent radiological predictor of outcome after thrombolysis in acute ischaemic stroke","volume":"45","author":"Kucinski","year":"2003","journal-title":"Neuroradiology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1161\/STROKEAHA.109.552513","article-title":"Collateral vessels on CT angiography predict outcome in acute ischemic stroke","volume":"40","author":"Maas","year":"2009","journal-title":"Stroke"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S1474-4422(11)70195-8","article-title":"Collateral blood vessels in acute ischaemic stroke: A potential therapeutic target","volume":"10","author":"Shuaib","year":"2011","journal-title":"Lancet Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1161\/STROKEAHA.110.595256","article-title":"Collateral flow predicts response to endovascular therapy for acute ischemic stroke","volume":"42","author":"Bang","year":"2011","journal-title":"Stroke"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1161\/STROKEAHA.113.004072","article-title":"Collaterals at angiography and outcomes in the Interventional Management of Stroke (IMS) III trial","volume":"45","author":"Liebeskind","year":"2014","journal-title":"Stroke"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Lakhani, D.A., Balar, A.B., Koneru, M., Wen, S., Hoseinyazdi, M., Greene, C., Xu, R., Luna, L., Caplan, J., and Dmytriw, A.A. (2023). The Compensation Index Is Better Associated with DSA ASITN Collateral Score Compared to the Cerebral Blood Volume Index and Hypoperfusion Intensity Ratio. J. Clin. Med., 12.","DOI":"10.3390\/jcm12237365"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Koneru, M., Hoseinyazdi, M., Lakhani, D.A., Greene, C., Copeland, K., Wang, R., Xu, R., Luna, L., Caplan, J.M., and Dmytriw, A.A. (2023). Redefining CT perfusion-based ischemic core estimates for the ghost core in early time window stroke. J. Neuroimaging.","DOI":"10.1111\/jon.13180"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/jon.13178","article-title":"Pretreatment CT perfusion collateral parameters correlate with penumbra salvage in middle cerebral artery occlusion","volume":"34","author":"Lakhani","year":"2023","journal-title":"J. Neuroimaging"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e109","DOI":"10.1161\/01.STR.0000082721.62796.09","article-title":"Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke","volume":"34","author":"Higashida","year":"2003","journal-title":"Stroke"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1161\/01.STR.0000126043.83777.3a","article-title":"Regional angiographic grading system for collateral flow: Correlation with cerebral infarction in patients with middle cerebral artery occlusion","volume":"35","author":"Kim","year":"2004","journal-title":"Stroke"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.03.012","article-title":"Assessment of arterial collateralization and its relevance to intra-arterial therapy for acute ischemic stroke","volume":"23","author":"Ramaiah","year":"2014","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1161\/STROKEAHA.113.003340","article-title":"Relative cerebral blood volume as a marker of durable tissue-at-risk viability in hyperacute ischemic stroke","volume":"45","author":"Cortijo","year":"2014","journal-title":"Stroke"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.neurad.2022.10.005","article-title":"Hypoperfusion intensity ratio and CBV index as predictive parameters to identify underlying intracranial atherosclerotic stenosis in endovascular thrombectomy","volume":"50","author":"Imaoka","year":"2023","journal-title":"J. Neuroradiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3174\/ajnr.A2809","article-title":"CT perfusion mean transit time maps optimally distinguish benign oligemia from true \"at-risk\" ischemic penumbra, but thresholds vary by postprocessing technique","volume":"33","author":"Kamalian","year":"2012","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/jon.12933","article-title":"Cerebral blood volume index as a predictor of functional independence after basilar artery thrombectomy","volume":"32","author":"Karamchandani","year":"2022","journal-title":"J. Neuroimaging"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jocn.2022.07.006","article-title":"Cerebral blood volume index may be a predictor of independent outcome of thrombectomy in stroke patients with low ASPECTS","volume":"103","author":"Li","year":"2022","journal-title":"J. Clin. Neurosci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"960","DOI":"10.3174\/ajnr.A7542","article-title":"RAPID CT Perfusion-Based Relative CBF Identifies Good Collateral Status Better Than Hypoperfusion Intensity Ratio, CBV-Index, and Time-to-Maximum in Anterior Circulation Stroke","volume":"43","author":"Potreck","year":"2022","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1136\/neurintsurg-2014-011501","article-title":"Relative CBV ratio on perfusion-weighted MRI indicates the probability of early recanalization after IV t-PA administration for acute ischemic stroke","volume":"8","author":"Sohn","year":"2016","journal-title":"J. Neurointerv. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1159\/000313303","article-title":"The CBV-ASPECT Score as a predictor of fatal stroke in a hyperacute state","volume":"63","author":"Kim","year":"2010","journal-title":"Eur. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000446969","article-title":"CBV_ASPECTS Improvement over CT_ASPECTS on Determining Irreversible Ischemic Lesion Decreases over Time","volume":"5","author":"Padroni","year":"2016","journal-title":"Interv. Neurol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1177\/0271678X17740293","article-title":"Relative cerebral blood volume is associated with collateral status and infarct growth in stroke patients in SWIFT PRIME","volume":"38","author":"Arenillas","year":"2018","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S0140-6736(20)30258-0","article-title":"Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): A multicentre, double-blind, randomised controlled trial","volume":"395","author":"Hill","year":"2020","journal-title":"Lancet"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1148\/radiol.14140951","article-title":"Collateral vessels in proximal middle cerebral artery occlusion: The ENDOSTROKE study","volume":"274","author":"Singer","year":"2015","journal-title":"Radiology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1161\/01.STR.0000227243.96808.53","article-title":"Identification of penumbra and infarct in acute ischemic stroke using computed tomography perfusion-derived blood flow and blood volume measurements","volume":"37","author":"Murphy","year":"2006","journal-title":"Stroke"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3174\/ajnr.A7954","article-title":"CT Perfusion Does Not Modify the Effect of Reperfusion in Patients with Acute Ischemic Stroke Undergoing Endovascular Treatment in the ESCAPE-NA1 Trial","volume":"44","author":"Rex","year":"2023","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3174\/ajnr.A1408","article-title":"CT angiography clot burden score and collateral score: Correlation with clinical and radiologic outcomes in acute middle cerebral artery infarct","volume":"30","author":"Tan","year":"2009","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1747-4949.2008.00221.x","article-title":"Intracranial thrombus extent predicts clinical outcome, final infarct size and hemorrhagic transformation in ischemic stroke: The clot burden score","volume":"3","author":"Puetz","year":"2008","journal-title":"Int. J. Stroke"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1148\/radiol.15142256","article-title":"Multiphase CT Angiography: A New Tool for the Imaging Triage of Patients with Acute Ischemic Stroke","volume":"275","author":"Menon","year":"2015","journal-title":"Radiology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1136\/neurintsurg-2018-014185","article-title":"Inter- and intraobserver reliability for angiographic leptomeningeal collateral flow assessment by the American Society of Interventional and Therapeutic Neuroradiology\/Society of Interventional Radiology (ASITN\/SIR) scale","volume":"11","author":"Malley","year":"2019","journal-title":"J. Neurointerv. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/acn3.51718","article-title":"Association between collaterals, cerebral circulation time and outcome after thrombectomy of stroke","volume":"10","author":"Wang","year":"2023","journal-title":"Ann. Clin. Transl. Neurol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/6\/1588\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:11:39Z","timestamp":1760105499000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/6\/1588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,10]]},"references-count":30,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["jcm13061588"],"URL":"https:\/\/doi.org\/10.3390\/jcm13061588","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,10]]}}}