{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:28:35Z","timestamp":1790458115660,"version":"4.1.0"},"reference-count":77,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The aim of this review was to investigate the influence of various laser refractive surgery methods on the corneal endothelium in myopic patients. The role of the corneal endothelium in laser refractive surgery (LRS) is currently being addressed in the assessment of postoperative corneal edema risk. Methods: Changes in corneal endothelial cell density and morphology after LRS were evaluated based on a systematic review of current studies. The results of a literature search in the PubMed, Science Direct, Google Scholar, and the Web of Science databases, as well as a manual search, were selected for the final review according to the PRISMA 2020 flow diagram. Results: We included 24 prospective clinical trials in the review: surface ablation (twelve), LASIK and FemtoLASIK (two), femtosecond lenticule extraction (two), and comparable studies (eight). Endothelial cell density was determined by specular or in vivo confocal microscopy. In most studies, no statistically significant differences were found between preoperative and postoperative endothelial parameters. In nine studies, the changes were statistically significant, but no vision-threatening complications occurred, and no serious corneal complications developed in any eyes during the follow-up period. Conclusions: Based on collected data, laser keratorefractive surgery appears not to exert a significant effect on the corneal endothelium.<\/jats:p>","DOI":"10.3390\/jcm13061665","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T05:43:08Z","timestamp":1710394988000},"page":"1665","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Evaluation of Corneal Endothelial Parameters following Laser Refractive Surgery in Myopic Eyes: A Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8849-6509","authenticated-orcid":false,"given":"Maciej","family":"Juda","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Military Institute of Medicine\u2014National Research Institute in Warsaw, 04-141 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Bedli\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Military Institute of Medicine\u2014National Research Institute in Warsaw, 04-141 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8083-3437","authenticated-orcid":false,"given":"Anna Maria","family":"Roszkowska","sequence":"additional","affiliation":[{"name":"Ophthalmology Clinic, Department of Biomorphological Sciences, University of Messina, 98124 Messina, Italy"},{"name":"Ophthalmology Section, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krak\u00f3w University, 30-705 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6993-7518","authenticated-orcid":false,"given":"Joanna","family":"Wierzbowska","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Military Institute of Medicine\u2014National Research Institute in Warsaw, 04-141 Warsaw, Poland"},{"name":"Optegra Eye Clinic, 02-366 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/s41433-020-1096-5","article-title":"Refractive surgery beyond 2020","volume":"35","author":"Ang","year":"2021","journal-title":"Eye"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/S0140-6736(12)60272-4","article-title":"Myopia","volume":"379","author":"Morgan","year":"2012","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","article-title":"Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050","volume":"123","author":"Holden","year":"2016","journal-title":"Ophthalmology"},{"key":"ref_4","first-page":"1","article-title":"Refractive Surgery","volume":"2020","author":"Jones","year":"2020","journal-title":"Market Report. MarketScope"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.jcrs.2016.07.012","article-title":"Modern laser in situ keratomileusis outcomes","volume":"42","author":"Sandoval","year":"2016","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1016\/S0140-6736(18)33209-4","article-title":"Refractive surgery","volume":"393","author":"Kim","year":"2019","journal-title":"Lancet"},{"key":"ref_7","first-page":"779","article-title":"Central corneal endothelial cell changes over a ten-year period","volume":"38","author":"Bourne","year":"1997","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00417-014-2812-2","article-title":"Aging and corneal layers, an in vivo corneal confocal microscopy study","volume":"253","author":"Gambato","year":"2015","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.sjopt.2016.10.003","article-title":"Corneal endothelial cell density in healthy Caucasian population","volume":"30","author":"Duman","year":"2016","journal-title":"Saudi J. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"251584141881580","DOI":"10.1177\/2515841418815802","article-title":"Corneal endothelial cell dysfunction, etiologies and management","volume":"10","author":"Feizi","year":"2018","journal-title":"Ther. Adv. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/ICO.0b013e31815892da","article-title":"Review of Corneal Endothelial Specular Microscopy for FDA Clinical Trials of Refractive Procedures, Surgical Devices, and New Intraocular Drugs and Solutions","volume":"27","author":"McCarey","year":"2008","journal-title":"Cornea"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1097\/00003226-200308000-00005","article-title":"Comparison of Confocal Biomicroscopy and Noncontact Specular Microscopy for Evaluation of the Corneal Endothelium","volume":"22","author":"Hara","year":"2003","journal-title":"Cornea"},{"key":"ref_13","first-page":"379","article-title":"Current evaluation of myopia correction with the excimer laser","volume":"92","author":"Seiler","year":"1995","journal-title":"Ophthalmologe"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0039-6257(95)80001-8","article-title":"Excimer laser photorefractive keratectomy","volume":"40","author":"Seiler","year":"1995","journal-title":"Surv. Ophthalmol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/(SICI)1096-9101(1996)19:1<23::AID-LSM4>3.0.CO;2-S","article-title":"Time-resolved observations of shock waves and cavitation bubbles generated by femtosecond laser pulses in corneal tissue and water","volume":"19","author":"Juhasz","year":"1996","journal-title":"Lasers Surg. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s004170050006","article-title":"Application of ultrashort laser pulses for intrastromal refractive surgery","volume":"238","author":"Lubatschowski","year":"2000","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"667","DOI":"10.3928\/1081-597X-20070901-05","article-title":"Femtosecond Laser and Microkeratome Corneal Flaps, Comparison of Stromal Wound Healing and Inflammation","volume":"23","author":"Netto","year":"2007","journal-title":"J. Refract. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ophtha.2007.03.073","article-title":"Risk Assessment for Ectasia after Corneal Refractive Surgery","volume":"115","author":"Randleman","year":"2008","journal-title":"Ophthalmology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/ICO.0b013e318030d217","article-title":"Mitomycin-C Concentration in Cornea and Aqueous Humor and Apoptosis in the Stroma After Topical Mitomycin-C Application","volume":"26","author":"Song","year":"2007","journal-title":"Cornea"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/S0886-3350(01)01352-9","article-title":"Endothelial decompensation after laser in situ keratomileusis","volume":"28","author":"Vroman","year":"2002","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/00003226-200305000-00020","article-title":"Corneal decompensation after laser in situ keratomileusis in fuchs\u2019 endothelial dystrophy","volume":"22","author":"Dastjerdi","year":"2003","journal-title":"Cornea"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/j.jcrs.2008.06.016","article-title":"Effect of intraoperative mitomycin-C on healthy corneal endothelium after laser-assisted subepithelial keratectomy","volume":"34","author":"Zhao","year":"2008","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3928\/1081597X-20180402-02","article-title":"Comparison of Single-Step Transepithelial Photorefractive Keratectomy with or Without Mitomycin C in Mild to Moderate Myopia","volume":"34","author":"Tefagh","year":"2018","journal-title":"J. Refract. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"S237","DOI":"10.3928\/1081-597X-20030302-13","article-title":"Effect of laser in situ keratomileusis on the corneal endothelium","volume":"19","author":"Simaroj","year":"2003","journal-title":"J. Refract. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"672","DOI":"10.3928\/1081597X-20110415-02","article-title":"Effects of LASIK on corneal endothelium using the 15-kHz IntraLase femtosecond laser","volume":"27","author":"Sakla","year":"2011","journal-title":"J. Refract. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1016\/j.jcrs.2012.06.052","article-title":"Early clinical outcomes, including efficacy and endothelial cell loss, of refractive lenticule extraction using a 500 kHz femtosecond laser to correct myopia","volume":"38","author":"Kamiya","year":"2012","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.clae.2015.03.011","article-title":"Short-term and long-term effects of small incision lenticule extraction (SMILE) on corneal endothelial cells","volume":"38","author":"Zhang","year":"2015","journal-title":"Cont. Lens Anterior Eye"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3928\/1081-597X-19940901-07","article-title":"Excimer laser in situ keratomileusis and photorefractive keratectomy for correction of high myopia","volume":"10","author":"Pallikaris","year":"1994","journal-title":"J. Refract. Corneal Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1001\/archophthalmol.2009.192","article-title":"Corneal Endothelial Cell Loss 9 Years After Excimer Laser Keratorefractive Surgery","volume":"127","author":"Patel","year":"2009","journal-title":"Arch. Ophthalmol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"S963","DOI":"10.3928\/1081597X-20090915-12","article-title":"Confocal microscopy of corneal stroma and endothelium after LASIK and PRK","volume":"25","author":"Amoozadeh","year":"2009","journal-title":"J. Refract. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3928\/1081597X-20140320-04","article-title":"The U.S. Army Surface Ablation Study, comparison of PRK, MMC-PRK, and LASEK in moderate to high myopia","volume":"30","author":"Sia","year":"2014","journal-title":"J. Refract. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ajo.2007.03.039","article-title":"Alterations in endothelial cell density after photorefractive keratectomy with adjuvant mitomycin","volume":"144","author":"Diakonis","year":"2007","journal-title":"Am. J. Ophthalmol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1016\/j.jcrs.2012.07.034","article-title":"Corneal endothelial cell changes 5 years after laser in situ keratomileusis, Femtosecond laser versus mechanical microkeratome","volume":"38","author":"Klingler","year":"2012","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.2147\/OPTH.S267567","article-title":"Comparison Between the Effect of Femtosecond Laser in situ Keratomileusis (FS-LASIK) and Femtosecond Small Incision Lenticule Extraction (FS-SMILE) on the Corneal Endothelium","volume":"14","author":"Shaaban","year":"2020","journal-title":"Clin. Ophthalmol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.jcrs.2008.03.007","article-title":"Corneal endothelial cell injury induced by mitomycin-C in photorefractive keratectomy, Nonrandomized controlled trial","volume":"34","author":"Nassiri","year":"2008","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s10792-017-0584-5","article-title":"Endothelial cell changes after photorefractive keratectomy with graded usage of mitomycin C","volume":"38","author":"Gharaee","year":"2018","journal-title":"Int. Ophthalmol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1001\/archopht.1996.01100140133003","article-title":"Central and peripheral endothelial cell changes after excimer laser photorefractive keratectomy for myopia","volume":"114","author":"Mack","year":"1996","journal-title":"Arch. Ophthalmol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1001\/archopht.1994.01090190068023","article-title":"The corneal endothelium after myopic excimer laser photorefractive keratectomy","volume":"112","author":"Carones","year":"1994","journal-title":"Arch. Ophthalmol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/S0002-9394(14)73467-1","article-title":"Corneal endothelial changes after excimer laser photorefractive keratectomy","volume":"116","author":"Amano","year":"1993","journal-title":"Am. J. Ophthalmol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0886-3350(96)80217-3","article-title":"Specular microscopy of the corneal endothelium after excimer laser photorefractive keratectomy","volume":"22","author":"Spadea","year":"1996","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3928\/1081-597X-19960201-05","article-title":"Tracker-Assisted Photorefractive Keratectomy for Myopia of -1 to -6 Diopters","volume":"12","author":"Pallikaris","year":"1996","journal-title":"J. Refract. Surg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1600-0420.1997.tb00106.x","article-title":"The corneal endothelium 12 months after photorefractive keratectomy in high myopia","volume":"75","author":"Cennamo","year":"1997","journal-title":"Acta Ophthalmol. Scand."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1001\/archopht.116.11.1425","article-title":"In vivo confocal microscopy after photorefractive keratectomy in humans. A prospective, long-term study","volume":"116","author":"Frueh","year":"1998","journal-title":"Arch. Ophthalmol."},{"key":"ref_44","first-page":"137","article-title":"Photorefractive keratectomy with a small spot laser and tracker","volume":"15","author":"Pallikaris","year":"1999","journal-title":"J. Refract. Surg."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Mardelli, P.G., Piebenga, L.W., Matta, C.S., Hyde, L.L., and Gira, J. (1995). Corneal endothelial status 12 to 55 months after excimer laser photorefractive keratectomy. Ophthalmology, 102.","DOI":"10.1016\/S0161-6420(95)30984-0"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0161-6420(85)33961-1","article-title":"An Ultrastructural Study of Corneal Incisions Induced by an Excimer Laser at 193 nm","volume":"92","author":"Marshall","year":"1985","journal-title":"Ophthalmology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1001\/archopht.1989.01070010917041","article-title":"Corneal Stromal Wound Healing in Rabbits After 193-nm Excimer Laser Surface Ablation","volume":"107","author":"Hanna","year":"1989","journal-title":"Arch. Ophthalmol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.jcrs.2011.01.012","article-title":"Corneal endothelium after refractive surgery","volume":"37","author":"Woodward","year":"2011","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"517","DOI":"10.4103\/ijo.IJO_574_20","article-title":"Specular microscopy in clinical practice","volume":"69","author":"Chaurasia","year":"2021","journal-title":"Indian J. Ophthalmol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1080\/02713680500536738","article-title":"Specular Microscopy Ancillary Study Methods for Donor Endothelial Cell Density Determination of Cornea Donor Study Images","volume":"31","author":"Benetz","year":"2006","journal-title":"Curr. Eye Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1097\/01.ico.0000159737.68048.97","article-title":"Comparison of corneal endothelial cell images from a noncontact specular microscope and a scanning confocal microscope","volume":"24","author":"Kitzmann","year":"2005","journal-title":"Cornea"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s004170100278","article-title":"Reliability and reproducibility of corneal endothelial image analysis by in vivo confocal microscopy","volume":"239","author":"Imre","year":"2001","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0002-9394(00)00664-4","article-title":"Effects of laser in situ keratomileusis (LASIK) on the corneal endothelium 3 years postoperatively","volume":"131","author":"Collins","year":"2001","journal-title":"Am. J. Ophthalmol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"912","DOI":"10.3928\/1081597X-20121116-01","article-title":"Femtosecond laser technology in corneal refractive surgery, a review","volume":"28","author":"Kymionis","year":"2012","journal-title":"J. Refract. Surg."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"278","DOI":"10.5455\/aim.2019.27.278-283","article-title":"Excimer Lasers in Refractive Surgery","volume":"27","author":"Pidro","year":"2019","journal-title":"Acta Inform. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ophtha.2006.07.019","article-title":"Femtosecond Laser versus Mechanical Keratome LASIK for Myopia","volume":"114","year":"2007","journal-title":"Ophthalmology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/00003226-200005000-00002","article-title":"The resiliency of the corneal endothelium to refractive and intraocular surgery","volume":"19","author":"Edelhauser","year":"2000","journal-title":"Cornea"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1097\/00003226-200108000-00008","article-title":"Acute Corneal Endothelial Changes After Laser In Situ Keratomileusis","volume":"20","author":"Kim","year":"2001","journal-title":"Cornea"},{"key":"ref_59","first-page":"276","article-title":"Keratocyte apoptosis after corneal surgery","volume":"39","author":"Helena","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"ref_60","first-page":"2395028","article-title":"Effect of Myopic Femtosecond Laser-Assisted LASIK on Anterior Chamber Inflammation (Flare Values) and Corneal Endothelium, A Prospective before and after Study","volume":"2021","author":"Altinkurt","year":"2021","journal-title":"J. Ophthalmol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3928\/15428877-20080301-05","article-title":"Errors of residual stromal thickness estimation in LASIK","volume":"39","author":"Cheng","year":"2008","journal-title":"Ophthal. Surg. Lasers Imag."},{"key":"ref_62","unstructured":"Moshirfar, M., Somani, S.N., and Patel, B.C. (2024). StatPearls, StatPearls Publishing."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"156","DOI":"10.51329\/mehdiophthal1434","article-title":"Effect of mitomycin-C on corneal endothelial cell parameters after refractive surface ablation procedures","volume":"10","author":"Moravej","year":"2022","journal-title":"Med. Hypothesis Discov. Innov. Ophthalmol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1001\/archopht.1997.01100160011001","article-title":"Evaluation of Endothelial Cell Changes 1 Year After Excimer Laser In Situ Keratomileusis","volume":"115","year":"1997","journal-title":"Arch. Ophthalmol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S1607-551X(09)70200-1","article-title":"Effects of Laser In Situ Keratomileusis on the Corneal Endothelium","volume":"21","author":"Chiang","year":"2005","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/00003226-200001000-00010","article-title":"The Effect of Contact Lens Wear on the Central and Peripheral Corneal Endothelium","volume":"19","author":"Wiffen","year":"2000","journal-title":"Cornea"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/S0161-6420(84)34169-0","article-title":"Diurnal Variation in Corneal Endothelial Morphologyp","volume":"91","author":"Khodadoust","year":"1984","journal-title":"Ophthalmology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1016\/S0886-3350(02)01701-7","article-title":"Evaluation of the prophylactic use of mitomycin-C to inhibit haze formation after photorefractive keratectomy","volume":"28","author":"Carones","year":"2002","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jcrs.2005.06.051","article-title":"Presence of mitomycin-C in the anterior chamber after photorefractive keratectomy","volume":"32","author":"Torres","year":"2006","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.jcrs.2007.02.034","article-title":"Effect of mitomycin-C on the corneal endothelium during excimer laser surface ablation","volume":"33","author":"Teus","year":"2007","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.2147\/OPTH.S375587","article-title":"Effect of Prophylactic Mitomycin C on Corneal Endothelium Following Transepithelial Photorefractive Keratectomy in Myopic Patients","volume":"16","year":"2022","journal-title":"Clin. Ophthalmol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.ophtha.2015.01.019","article-title":"Mitomycin-C in Corneal Surface Excimer Laser Ablation Techniques","volume":"122","author":"Majmudar","year":"2015","journal-title":"Ophthalmology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1097\/j.jcrs.0000000000000468","article-title":"Laser refractive surgery in corneal dystrophies","volume":"47","author":"Borroni","year":"2021","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1016\/j.jcrs.2004.05.061","article-title":"Laser in situ keratomileusis in patients with corneal guttata and family history of Fuchs\u2019 endothelial dystrophy","volume":"31","author":"Moshirfar","year":"2005","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/01.ico.0000139634.88153.bb","article-title":"Laser in situ keratomileusis in patients with posterior polymorphous dystrophy","volume":"24","author":"Moshirfar","year":"2005","journal-title":"Cornea"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.jcrs.2010.12.045","article-title":"Photorefractive keratectomy in posterior polymorphous dystrophy with vesicular and band subtypes","volume":"37","author":"Bower","year":"2011","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jcrs.2016.04.001","article-title":"Small-incision lenticule extraction in posterior polymorphic corneal dystrophy","volume":"42","author":"Park","year":"2016","journal-title":"J. Cataract. Refract. Surg."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/6\/1665\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:13:27Z","timestamp":1760105607000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/6\/1665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,14]]},"references-count":77,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["jcm13061665"],"URL":"https:\/\/doi.org\/10.3390\/jcm13061665","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,14]]}}}