{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:40:29Z","timestamp":1789425629317,"version":"build-2803163510"},"reference-count":41,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: To investigate the geometry of the aortoiliac (AI) segment and its correlation with sex, age, and cardiovascular (CV) risk factors. Methods: Abdominal and pelvic CTA\/MRA scans of 204 subjects (120 males; median age: 53 [IQR, 27\u201375] years) without AI steno-occlusive disease or scoliosis were retrospectively analyzed. The participants were enrolled consecutively, ensuring the representation of each age decade. An in-house written software was developed to assess AI elongation using the tortuosity index (TI) and absolute average curvature (AAC). Aortic bifurcation angle, common iliac artery (CIA) take-off and planarity angles, bifurcation asymmetry, and deviation from optimal bifurcation were calculated and evaluated. Demographic data, CV risk factors, and medical history were collected from electronic health records. Results: The elongation of the iliac arteries was more pronounced in males (TI: left CIA, p = 0.011; left EIA, p &lt; 0.001; right CIA, p = 0.023; right EIA, p &lt; 0.001; AAC: left EIA, p &lt; 0.001; right EIA, p = 0.001). Age significantly influenced TI and AAC in all AI segments (all p &lt; 0.001), but was also positively associated with the aortic bifurcation angle (p &lt; 0.001), both CIA planarities (left, p &lt; 0.001; right, p = 0.002), aortic bifurcation asymmetry (p = 0.001), and radius discrepancy (p &lt; 0.001). Significant positive correlations were found between infrarenal aortic TI\/AAC and chronic kidney disease (CKD) (p = 0.027 and p = 0.016), AAC of both CIAs and hypertension (left, p = 0.027; right, p = 0.012), right CIA take-off angle and CKD (p = 0.031), and left CIA planarity and hyperlipidemia (p = 0.006). Conclusion: Sex, age, and CV risk factors have a significant effect on the geometry of the AI segment.<\/jats:p>","DOI":"10.3390\/jcm13061705","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T12:02:39Z","timestamp":1710504159000},"page":"1705","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Sex, Age, and Cardiovascular Risk Factors on Aortoiliac Segment Geometry"],"prefix":"10.3390","volume":"13","author":[{"given":"\u00c1d\u00e1m","family":"Sz\u0151nyi","sequence":"first","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6rgy","family":"Bal\u00e1zs","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary"},{"name":"Heim P\u00e1l National Pediatric Institute, 1089 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs Bence","family":"Ny\u00e1r\u00e1dy","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rton","family":"Philippovich","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3038-8643","authenticated-orcid":false,"given":"Tam\u00e1s","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"Research Center for Sport Physiology, Hungarian University of Sports Science, 1123 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edit","family":"D\u00f3sa","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e171","DOI":"10.1161\/CIR.0000000000001005","article-title":"Lower Extremity Peripheral Artery Disease: Contemporary Epidemiology, Management Gaps, and Future Directions: A Scientific Statement from the American Heart Association","volume":"144","author":"Criqui","year":"2021","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1161\/CIRCRESAHA.116.303849","article-title":"Epidemiology of peripheral artery disease","volume":"116","author":"Criqui","year":"2015","journal-title":"Circ. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1001\/jama.2021.2126","article-title":"Lower Extremity Peripheral Artery Disease without Chronic Limb-Threatening Ischemia: A Review","volume":"325","author":"Polonsky","year":"2021","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e13491","DOI":"10.1111\/eci.13491","article-title":"The Iliofemoral tortuosity score predicts access and bleeding complications during transfemoral transcatheter aortic valve replacement: Data from the VIenna Cardio Thoracic aOrtic valve registrY (VICTORY)","volume":"51","author":"Mach","year":"2021","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.jvs.2022.01.142","article-title":"Effect of iliac tortuosity on outcomes after iliac branch procedures","volume":"76","author":"Fenelli","year":"2022","journal-title":"J. Vasc. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jvs.2009.08.080","article-title":"Echolucent or predominantly echolucent femoral plaques predict early restenosis after eversion carotid endarterectomy","volume":"51","author":"Hirschberg","year":"2010","journal-title":"J. Vasc. Surg."},{"key":"ref_7","unstructured":"(2023, August 06). 3D Slicer Image Computing Platform. 3D Slicer. Available online: https:\/\/www.slicer.org."},{"key":"ref_8","unstructured":"Ferenc, A.J. (2014). Intraoperative Imaging Image-Guided Therapy, Springer. ISBN: 978-1-4614-7656-6 (Print) 978-1-4614-7657-3 (Online)."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.media.2016.06.035","article-title":"Increasing the impact of medical image computing using community-based open-access hackathons: The NA-MIC and 3D Slicer experience","volume":"33","author":"Kapur","year":"2016","journal-title":"Med. Image Anal."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.mri.2012.05.001","article-title":"3D Slicer as an image computing platform for the Quantitative Imaging Network","volume":"30","author":"Fedorov","year":"2012","journal-title":"Magn. Reson. Imaging"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cmpb.2019.02.011","article-title":"Polymorph segmentation representation for medical image computing","volume":"171","author":"Pinter","year":"2019","journal-title":"Comput. Methods Programs Biomed."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/s11517-008-0420-1","article-title":"An image-based modeling framework for patient-specific computational hemodynamics","volume":"46","author":"Antiga","year":"2008","journal-title":"Med. Biol. Eng. Comput."},{"key":"ref_13","unstructured":"(2023, August 10). The Vascular Modelling Toolkit. VMTK. Available online: https:\/\/www.vmtk.org."},{"key":"ref_14","first-page":"181","article-title":"Aortic bifurcation angle as an independent risk factor for aortoiliac occlusive disease","volume":"66","author":"Shakeri","year":"2007","journal-title":"Folia Morphol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1073\/pnas.12.3.207","article-title":"The Physiological Principle of Minimum Work: I. The Vascular System and the Cost of Blood Volume","volume":"12","author":"Murray","year":"1926","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1085\/jgp.9.6.835","article-title":"The physiological principle of minimum work applied to the angle of branching of arteries","volume":"9","author":"Murray","year":"1926","journal-title":"J. Gen. Physiol."},{"key":"ref_17","unstructured":"JASP Team (2023, August 10). JASP (Version 0.17.3) [Computer Software]. Available online: https:\/\/jasp-stats.org\/."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ejrad.2018.11.017","article-title":"The effect of age and gender on tortuosity of the descending thoracic Aorta","volume":"110","author":"Tawfik","year":"2019","journal-title":"Eur. J. Radiol."},{"key":"ref_19","first-page":"68","article-title":"Carotid artery tortuosity, kinking, coiling: Stroke risk factor, marker, or curiosity?","volume":"105","author":"Kim","year":"2005","journal-title":"Acta Neurol. Belg."},{"key":"ref_20","first-page":"23","article-title":"Gender differences in the prevalence of coronary artery tortuosity and its association with coronary artery disease","volume":"14","author":"Chiha","year":"2016","journal-title":"Int. J. Cardiol. Heart Vasc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1152\/japplphysiol.00051.2006","article-title":"Curvature and tortuosity of the superficial femoral artery: A possible risk factor for peripheral arterial disease","volume":"101","author":"Wood","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.avsg.2023.02.034","article-title":"Iliac Artery Tortuosity Index in Chinese Patients with or without Aortic Artery Aneurysms and Related Influencing Factors","volume":"94","author":"Song","year":"2023","journal-title":"Ann. Vasc. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Belvroy, V.M., de Beaufort, H.W.L., van Herwaarden, J.A., Bismuth, J., Moll, F.L., and Trimarchi, S. (2019). Tortuosity of the descending thoracic aorta: Normal values by age. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0215549"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1161\/01.STR.0000185679.62634.0a","article-title":"Variation in the carotid bifurcation geometry of young versus older adults: Implications for geometric risk of atherosclerosis","volume":"36","author":"Thomas","year":"2005","journal-title":"Stroke"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"858805","DOI":"10.3389\/fneur.2022.858805","article-title":"Age-Related Tortuosity of Carotid and Vertebral Arteries: Quantitative Evaluation with MR Angiography","volume":"13","author":"Sun","year":"2022","journal-title":"Front. Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"209","DOI":"10.15171\/jcvtr.2018.36","article-title":"The significant coronary tortuosity and atherosclerotic coronary artery disease; What is the relation?","volume":"10","author":"Joharimoghadam","year":"2018","journal-title":"J. Cardiovasc. Thorac. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1139\/o59-059","article-title":"The effect of age on the elasticity of human iliac arteries","volume":"37","author":"Roach","year":"1959","journal-title":"Can. J. Biochem. Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Li, M., Wang, Z.W., Fang, L.J., Cheng, S.Q., Wang, X., and Liu, N.F. (2022). Correlation analysis of coronary artery tortuosity and calcification score. BMC Surg., 22.","DOI":"10.1186\/s12893-022-01470-w"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"508","DOI":"10.3389\/fneur.2017.00508","article-title":"Extracranial Internal Carotid Artery Tortuosity and Body Mass Index","volume":"8","author":"Wang","year":"2017","journal-title":"Front. Neurol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1136\/neurintsurg-2013-010987","article-title":"High curvature of the internal carotid artery is associated with the presence of intracranial aneurysms","volume":"6","author":"Lauric","year":"2014","journal-title":"J. NeuroInterv. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.atherosclerosis.2016.02.022","article-title":"Smoking is associated with lower amounts of arterial type I collagen and decorin","volume":"247","author":"Faarvang","year":"2016","journal-title":"Atherosclerosis"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Li, Y., Shen, C., Ji, Y., Feng, Y., Ma, G., and Liu, N. (2011). Clinical implication of coronary tortuosity in patients with coronary artery disease. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0024232"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000335123","article-title":"Twisted blood vessels: Symptoms, etiology and biomechanical mechanisms","volume":"49","author":"Han","year":"2012","journal-title":"J. Vasc. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.pharmthera.2005.12.003","article-title":"Elastic fibres and vascular structure in hypertension","volume":"111","author":"Arribas","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"ref_35","first-page":"14","article-title":"Severe coronary tortuosity and the relationship to significant coronary artery disease","volume":"105","author":"Groves","year":"2009","journal-title":"West Va. Med. J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1161\/HYPERTENSIONAHA.111.187807","article-title":"Elastin degradation is associated with progressive aortic stiffening and all-cause mortality in predialysis chronic kidney disease","volume":"59","author":"Smith","year":"2012","journal-title":"Hypertension"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"H873","DOI":"10.1152\/ajpheart.00463.2011","article-title":"Effects of elastin degradation and surrounding matrix support on artery stability","volume":"302","author":"Lee","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_38","first-page":"1564","article-title":"Anatomical variations of the position of the aortic bifurcation, iliocava junction and iliac veins in relation to the lumbar vertebra","volume":"91","author":"Lakchayapakorn","year":"2008","journal-title":"J. Med. Assoc. Thai."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/BF02368230","article-title":"Measurement of the geometric parameters of the aortic bifurcation from magnetic resonance images","volume":"22","author":"Sun","year":"1994","journal-title":"Ann. Biomed. Eng."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.10.026","article-title":"Widening and Rotation of Carotid Artery with Age: Geometric Approach","volume":"27","author":"Jeon","year":"2018","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.atherosclerosis.2011.12.040","article-title":"Deviation from Murray's law is associated with a higher degree of calcification in coronary bifurcations","volume":"221","author":"Schoenenberger","year":"2012","journal-title":"Atherosclerosis"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/6\/1705\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:14:27Z","timestamp":1760105667000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/6\/1705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,15]]},"references-count":41,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["jcm13061705"],"URL":"https:\/\/doi.org\/10.3390\/jcm13061705","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,15]]}}}