{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:58:25Z","timestamp":1780077505504,"version":"3.54.0"},"reference-count":38,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T00:00:00Z","timestamp":1710547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"CONACYT, Mexico","doi-asserted-by":"publisher","award":["FOSIS 2015-262023."],"award-info":[{"award-number":["FOSIS 2015-262023."]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: This study explores the impact of a gluten-free diet (GFD) on regional gastrointestinal (GI) transit times in individuals with celiac disease (CD) and non-celiac gluten sensitivity (NCGS). While a GFD is established for managing CD and wheat allergy, its effects on NCGS remain controversial due to inconclusive evidence. Methods: Utilizing a wireless motility and pH capsule (WMC) to assess regional (measurements of gastric, small bowel, and colonic transit times) and whole gut transit, newly diagnosed CD (n = 12) and NCGS (n = 12) patients underwent evaluations at baseline and 4 weeks after having a GFD. Results: At baseline conditions, individuals diagnosed with CD exhibited prolonged colonic and intestinal transit times when compared to those with NCGS (p &lt; 0.05). Following a 4-week GFD, CD patients experienced significant reductions in both intestinal and colonic transit times, along with enhanced small intestine contractility. NCGS individuals showed improvements in intestinal transit time and contractility with a GFD, although the colon exhibited no discernible effect. The GFD did not significantly impact intragastric, intestinal, or colonic pH. Conclusions: This study, employing WMC for the first time, provides novel insights into the positive effects of a GFD on intestinal and colonic transit, as well as contractility, in CD patients, and to a lesser extent, in those with NCGS.<\/jats:p>","DOI":"10.3390\/jcm13061716","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T04:25:15Z","timestamp":1710735915000},"page":"1716","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of a Gluten-Free Diet on Whole Gut Transit Time in Celiac Disease (CD) and Non-Celiac Gluten Sensitivity (NCGS) Patients: A Study Using the Wireless Motility Capsule (WMC)"],"prefix":"10.3390","volume":"13","author":[{"given":"Orestes","family":"Cobos-Quevedo","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones M\u00e9dico-Biol\u00f3gicas, Universidad Veracruzana, Veracruz 91400, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gildardo Alfonso","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones M\u00e9dico-Biol\u00f3gicas, Universidad Veracruzana, Veracruz 91400, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1330-8285","authenticated-orcid":false,"given":"Xaira Jimena","family":"Rivera-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones M\u00e9dico-Biol\u00f3gicas, Universidad Veracruzana, Veracruz 91400, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Grube-Pagola","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones M\u00e9dico-Biol\u00f3gicas, Universidad Veracruzana, Veracruz 91400, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8478-9659","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"Remes-Troche","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones M\u00e9dico-Biol\u00f3gicas, Universidad Veracruzana, Veracruz 91400, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/gutjnl-2011-301346","article-title":"The Oslo definitions for coeliac disease and related terms","volume":"62","author":"Ludvigsson","year":"2013","journal-title":"Gut"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cgh.2017.06.037","article-title":"Global prevalence of celiac disease: Systematic review and meta-analysis","volume":"16","author":"Singh","year":"2018","journal-title":"Clin. 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