{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:49:11Z","timestamp":1793378951477,"version":"4.5.0"},"reference-count":34,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korean government (MSIT)","award":["2022000218"],"award-info":[{"award-number":["2022000218"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: We aimed to analyze the clinical outcomes and effectiveness of cervical biportal endoscopic spine surgery (C-BESS) and anterior cervical discectomy and fusion (ACDF) in patients with symptomatic cervical disc herniation. Methods: This study was a retrospective chart review of four-year clinical data involving 318 cases of symptomatic cervical disc herniation, with 156 patients undergoing the ACDF and 162 patients receiving the C-BESS. Preoperative and postoperative one-year data were collected. Results: The numeric rating scale and neck disability index showed statistically significant improvement for both ACDF and C-BESS groups. While showing a longer operation time and more blood loss during surgery compared to the ACDF group, the C-BESS group demonstrated a learning effect as the surgeon\u2019s proficiency increased with more cases. There was no significant difference in the postoperative length of hospitalization between the two methods. The subgroup with predominant arm pain revealed the statistical difference in arm pain intensity changes between the two groups (p &lt; 0.001). The rates of complication were 2.6% for the ACDF group and 1.9% for the C-BESS group. Conclusions: C-BESS and ACDF are effective surgical treatments for patients with symptomatic single-level cervical disc herniation in relieving relevant pain intensities and pain-related disabilities.<\/jats:p>","DOI":"10.3390\/jcm13061823","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T11:37:22Z","timestamp":1711021042000},"page":"1823","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of Cervical Biportal Endoscopic Spine Surgery and Anterior Cervical Discectomy and Fusion in Patients with Symptomatic Cervical Disc Herniation"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6651-0674","authenticated-orcid":false,"given":"Seok-Bong","family":"Jung","sequence":"first","affiliation":[{"name":"Spine Center, Jinju Bon Hospital, Jinju-si 52703, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishant","family":"Gunadala","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Government Hospital Ahmedabad, Ahmedabad 380049, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9650-2755","authenticated-orcid":false,"given":"Nackhwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Korea University Guro Hospital, Seoul 08308, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1056\/NEJMcp043887","article-title":"Clinical practice","volume":"353","author":"Carette","year":"2005","journal-title":"Cervical radiculopathy. N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/BSD.0b013e31820d77ea","article-title":"Incidence and epidemiology of cervical radiculopathy in the United States military: 2000 to 2009","volume":"25","author":"Schoenfeld","year":"2012","journal-title":"J. Spinal Disord. Tech."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1097\/BRS.0000000000000792","article-title":"A biodegradable glue for annulus closure: Evaluation of strength and endurance","volume":"40","author":"Vergroesen","year":"2015","journal-title":"Spine"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"100","DOI":"10.25259\/SNI-191-2019","article-title":"A Review of Complication Rates for Anterior Cervical Diskectomy and Fusion (ACDF)","volume":"10","author":"Epstein","year":"2019","journal-title":"Surg. Neurol. Int."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S171","DOI":"10.1097\/BRS.0b013e3182a7f4ff","article-title":"Surgical management of degenerative cervical myelopathy: A consensus statement","volume":"38","author":"Lawrence","year":"2013","journal-title":"Spine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2531\/spinalsurg.21.91","article-title":"Dynamic Plating for Single Level Anterior Diskectomy\/Fusion: A Study Comparing Morbidity with Single Level Anterior Corpectomy\/Fusion","volume":"21","author":"Epstein","year":"2007","journal-title":"Spinal Surg."},{"key":"ref_7","first-page":"153","article-title":"The safety and efficacy of percutaneous transforaminal endoscopic discectomy and fenestration discectomy in the treatment of lumbar disc herniation","volume":"91","author":"Zhao","year":"2023","journal-title":"Cir. Cir."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Zheng, B., Hao, D., Guo, H., and He, B. (2017). ACDF vs TDR for patients with cervical spondylosis\u2014An 8 year follow up study. BMC Surg., 17.","DOI":"10.1186\/s12893-017-0316-9"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s00264-017-3745-2","article-title":"Outcomes of the Bryan cervical disc replacement: Fifteen year follow-up","volume":"42","author":"Pointillart","year":"2018","journal-title":"Int. Orthop."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s00264-016-3193-4","article-title":"Microsurgery or open cervical foraminotomy for cervical radiculopathy?","volume":"40","author":"Song","year":"2016","journal-title":"A systematic review. Int. Orthop."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2106\/00004623-199274010-00004","article-title":"Cervical stability after foraminotomy","volume":"74","author":"Zdeblick","year":"1992","journal-title":"A biomechanical in vitro analysis. J. Bone Jt. Surg. Am."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.13107\/jocr.2023.v13.i12.4120","article-title":"The Past, Present, and Future of Unilateral Biportal Endoscopy with a Technical Note on Novel Endoscopic Visualization Pedicle Screw Insertion Technique and UBE-transforaminal Lumbar Interbody Fusion Technique with Literature Review","volume":"13","author":"Sakhrekar","year":"2023","journal-title":"J. Orthop. Case Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e29751","DOI":"10.1097\/MD.0000000000029751","article-title":"Biportal endoscopic spine surgery for cervical disk herniation: A technical notes and preliminary report","volume":"101","author":"Jung","year":"2022","journal-title":"Medicine"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Zhu, C., Zhou, X., Ge, G., Wang, C., Zhuang, X., Cheng, W., Wang, D., Zhu, H., Pan, H., and Zhang, W. (2023). Unilateral Biportal Endoscopic Laminectomy for Treating Cervical Stenosis: A Technical Note and Preliminary Results. Medicina, 59.","DOI":"10.3390\/medicina59020305"},{"key":"ref_15","first-page":"409","article-title":"The Neck Disability Index: A study of reliability and validity","volume":"14","author":"Vernon","year":"1991","journal-title":"J. Manip. Physiol. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"S126","DOI":"10.1097\/00000542-198009001-00126","article-title":"A computer nomogram for blood loss replacement","volume":"53","author":"Ward","year":"1980","journal-title":"J. Am. Soc. Anesthesiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/00004311-197513030-00007","article-title":"Intraoperative fluid therapy","volume":"13","author":"Furman","year":"1975","journal-title":"Int. Anesthesiol. Clin."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1213\/ANE.0000000000001992","article-title":"Determination of Perioperative Blood Loss: Accuracy or Approximation?","volume":"125","author":"Albinarrate","year":"2017","journal-title":"Anesth. Analg."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Ahn, Y., Keum, H.J., and Shin, S.H. (2020). Percutaneous Endoscopic Cervical Discectomy Versus Anterior Cervical Discectomy and Fusion: A Comparative Cohort Study with a Five-Year Follow-Up. J. Clin. Med., 9.","DOI":"10.3390\/jcm9020371"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1002\/nau.22375","article-title":"Analysis of the surgical learning curve using the cumulative sum (CUSUM) method","volume":"32","author":"Maguire","year":"2013","journal-title":"Neurourol. Urodyn."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1007\/s00586-012-2297-9","article-title":"Lack of uniform diagnostic criteria for cervical radiculopathy in conservative intervention studies: A systematic review","volume":"21","author":"Thoomes","year":"2012","journal-title":"Eur. Spine J."},{"key":"ref_22","first-page":"72","article-title":"Anterior cervical disc arthroplasty (ACDA) versus anterior cervical discectomy and fusion (ACDF): A systematic review and meta-analysis","volume":"1","author":"Maharaj","year":"2015","journal-title":"J. Spine Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"302","DOI":"10.21037\/jss.2020.01.14","article-title":"Complications of anterior cervical spine surgery: A systematic review of the literature","volume":"6","author":"Yee","year":"2020","journal-title":"J. Spine Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1159\/000351887","article-title":"Long-term results of anterior versus posterior operations for herniated cervical discs: Analysis of 6,000 patients","volume":"23","author":"Dohrmann","year":"2014","journal-title":"Med. Princ. Pract."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"911914","DOI":"10.3389\/fsurg.2022.911914","article-title":"Efficacy and safety of unilateral biportal endoscopy versus other spine surgery: A systematic review and meta-analysis","volume":"9","author":"Zheng","year":"2022","journal-title":"Front. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"629","DOI":"10.14444\/5078","article-title":"Arm Pain Versus Neck Pain: A Novel Ratio as a Predictor of Post-Operative Clinical Outcomes in Cervical Radiculopathy Patients","volume":"12","author":"Passias","year":"2018","journal-title":"Int. J. Spine Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00002517-200102000-00004","article-title":"Comparison of biomechanical response to surgical procedures used for cervical radiculopathy: Posterior keyhole foraminotomy versus anterior foraminotomy and discectomy versus anterior discectomy with fusion","volume":"14","author":"Chen","year":"2001","journal-title":"J. Spinal Disord."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3171\/jns.1985.63.2.0278","article-title":"Cervical facetectomy and its effect on spine strength","volume":"63","author":"Raynor","year":"1985","journal-title":"J. Neurosurg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e27970","DOI":"10.1097\/MD.0000000000027970","article-title":"Efficacy and safety of unilateral biportal endoscopy compared with microscopic decompression in the treatment of lumbar spinal stenosis: A protocol for systematic review and meta-analysis","volume":"100","author":"Li","year":"2021","journal-title":"Medicine"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"873691","DOI":"10.3389\/fsurg.2022.873691","article-title":"The Learning Curve of Unilateral Biportal Endoscopic (UBE) Spinal Surgery by CUSUM Analysis","volume":"9","author":"Chen","year":"2022","journal-title":"Front. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e24346","DOI":"10.1097\/MD.0000000000024346","article-title":"Learning curve of percutaneous endoscopic transforaminal lumbar discectomy by a single surgeon","volume":"100","author":"Son","year":"2021","journal-title":"Medicine"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1007\/s00701-023-05706-3","article-title":"Biportal endoscopic paraspinal decompressive foraminotomy for lumbar foraminal stenosis: Clinical outcomes and factors influencing unsatisfactory outcomes","volume":"165","author":"You","year":"2023","journal-title":"Acta Neurochir."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"14350","DOI":"10.1038\/s41598-022-18417-z","article-title":"Analysis of risk factors for perioperative complications in spine surgery","volume":"12","author":"Lange","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.14245\/ns.2346190.095","article-title":"Current Indications for Spinal Endoscopic Surgery and Potential for Future Expansion","volume":"20","author":"Chen","year":"2023","journal-title":"Neurospine"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/6\/1823\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:17:35Z","timestamp":1760105855000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/6\/1823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,21]]},"references-count":34,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["jcm13061823"],"URL":"https:\/\/doi.org\/10.3390\/jcm13061823","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,21]]}}}