{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T03:28:55Z","timestamp":1771298935652,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Pulmonary hypertension (PH) patients are at higher risk of postoperative complications. We analyzed the association of PH with 30-day postoperative pulmonary complications (PPCs). Methods: A single-center propensity score overlap weighting (OW) retrospective cohort study was conducted on 164 patients with a mean pulmonary artery pressure (mPAP) of &gt;20 mmHg within 24 months of undergoing elective inpatient abdominal surgery or endoscopic procedures under general anesthesia and a control cohort (N = 1981). The primary outcome was PPCs, and the secondary outcomes were PPC sub-composites, namely respiratory failure (RF), pneumonia (PNA), aspiration pneumonia\/pneumonitis (ASP), pulmonary embolism (PE), length of stay (LOS), and 30-day mortality. Results: PPCs were higher in the PH cohort (29.9% vs. 11.2%, p &lt; 0.001). When sub-composites were analyzed, higher rates of RF (19.3% vs. 6.6%, p &lt; 0.001) and PNA (11.2% vs. 5.7%, p = 0.01) were observed. After OW, PH was still associated with greater PPCs (RR 1.66, 95% CI (1.05\u20132.71), p = 0.036) and increased LOS (median 8.0 days vs. 4.9 days) but not 30-day mortality. Sub-cohort analysis showed no difference in PPCs between pre- and post-capillary PH patients. Conclusions: After covariate balancing, PH was associated with a higher risk for PPCs and prolonged LOS. This elevated PPC risk should be considered during preoperative risk assessment.<\/jats:p>","DOI":"10.3390\/jcm13071996","type":"journal-article","created":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T06:33:16Z","timestamp":1711693996000},"page":"1996","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pulmonary Hypertension and the Risk of 30-Day Postoperative Pulmonary Complications after Gastrointestinal Surgical or Endoscopic Procedures: A Retrospective Propensity Score-Weighted Cohort Analysis"],"prefix":"10.3390","volume":"13","author":[{"given":"Yoshio","family":"Tatsuoka","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06510, USA"},{"name":"Department of Anesthesiology, Yale New Haven Hospital, New Haven, CT 06510, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6970-3340","authenticated-orcid":false,"given":"Zyad J.","family":"Carr","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06510, USA"},{"name":"Department of Anesthesiology, Yale New Haven Hospital, New Haven, CT 06510, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachidhanand","family":"Jayakumar","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Mo","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06510, USA"},{"name":"Department of Anesthesiology, Yale New Haven Hospital, New Haven, CT 06510, USA"},{"name":"Yale Center for Analytical Sciences, Yale School of Public Health, New Haven, CT 06520, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zili","family":"He","sequence":"additional","affiliation":[{"name":"Yale Center for Analytical Sciences, Yale School of Public Health, New Haven, CT 06520, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adham","family":"Farroukh","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Perioperative Medicine, Tufts Medical Center, Boston, MA 01803, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Heerdt","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06510, USA"},{"name":"Department of Anesthesiology, Yale New Haven Hospital, New Haven, CT 06510, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e029024","DOI":"10.1161\/JAHA.122.029024","article-title":"Revised Definition of Pulmonary Hypertension and Approach to Management: A Clinical Primer","volume":"12","author":"Maron","year":"2023","journal-title":"J. Am. Heart Assoc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1053\/j.jvca.2021.06.036","article-title":"Pulmonary Hypertension in 2021: Part I-Definition, Classification, Pathophysiology, and Presentation","volume":"36","author":"Gelzinis","year":"2022","journal-title":"J. Cardio-thorac. Vasc. Anesth."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1016\/j.jacc.2005.02.055","article-title":"Impact of pulmonary hypertension on the outcomes of noncardiac surgery: Predictors of perioperative morbidity and mortality","volume":"45","author":"Ramakrishna","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.bja.2021.01.005","article-title":"Perioperative management of patients with pulmonary hypertension undergoing non-cardiothoracic, non-obstetric surgery: A systematic review and expert consensus statement","volume":"126","author":"Price","year":"2021","journal-title":"Br. J. Anaesth."},{"key":"ref_5","first-page":"392","article-title":"Postoperative pulmonary complications in contemporary cohort of patients with pulmonary hypertension","volume":"19","author":"Kruthiventi","year":"2019","journal-title":"Bosn. J. Basic. Med. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"969","DOI":"10.33963\/KP.14940","article-title":"Right ventricular systolic pressure as a predictive factor for postoperative pneumonia in patients with valvular heart disease","volume":"77","author":"Duchnowski","year":"2019","journal-title":"Kardiol. Pol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.surg.2020.08.009","article-title":"Relationships between predischarge and postdischarge infectious complications, length of stay, and unplanned readmissions in the ACS NSQIP database","volume":"169","author":"Aasen","year":"2020","journal-title":"Surgery"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00005650-199801000-00004","article-title":"Comorbidity measures for use with administrative data","volume":"36","author":"Elixhauser","year":"1998","journal-title":"Med. Care"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1002\/bjs.9638","article-title":"Development and validation of the Surgical Outcome Risk Tool (SORT)","volume":"101","author":"Protopapa","year":"2014","journal-title":"Br. J. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/S0735-1097(03)00947-1","article-title":"Noncardiac comorbidity increases preventable hospitalizations and mortality among medicare beneficiaries with chronic heart failure","volume":"42","author":"Braunstein","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s10741-011-9258-y","article-title":"Frailty and multiple comorbidities in the elderly patient with heart failure: Implications for management","volume":"17","author":"Murad","year":"2012","journal-title":"Heart Fail. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1001\/jama.2020.7819","article-title":"Overlap Weighting: A Propensity Score Method That Mimics Attributes of a Randomized Clinical Trial","volume":"323","author":"Thomas","year":"2020","journal-title":"JAMA"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1001\/jama.2019.21558","article-title":"Using Propensity Score Methods to Create Target Populations in Observational Clinical Research","volume":"323","author":"Thomas","year":"2020","journal-title":"JAMA"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S2213-2600(15)00543-3","article-title":"A global view of pulmonary hypertension","volume":"4","author":"Hoeper","year":"2016","journal-title":"Lancet Respir. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"958","DOI":"10.4187\/002013209793800439","article-title":"Postoperative Pulmonary Hypertension: Etiology and Treatment of a Dangerous Complication","volume":"54","author":"Hill","year":"2009","journal-title":"Respir. Care"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1213\/ANE.0000000000005175","article-title":"Systemic Inflammatory Response Syndrome After Surgery: Mechanisms and Protection","volume":"131","author":"Margraf","year":"2020","journal-title":"Anesth. Analg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"221","DOI":"10.31729\/jnma.3144","article-title":"Systemic Inflammatory Response Syndrome following Gastrointestinal Surgery","volume":"56","author":"Koirala","year":"2017","journal-title":"J. Nepal. Med. Assoc."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.jacc.2008.12.038","article-title":"C-reactive protein: A new predictor of adverse outcome in pulmonary arterial hypertension","volume":"53","author":"Quarck","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00109-022-02197-0","article-title":"Nets, pulmonary arterial hypertension, and thrombo-inflammation","volume":"100","author":"Santos","year":"2022","journal-title":"J. Mol. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1096871","DOI":"10.3389\/fcvm.2023.1096871","article-title":"Fluid management in septic patients with pulmonary hypertension, review of the literature","volume":"10","author":"Asllanaj","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s41030-018-0052-z","article-title":"Volume Management in Pulmonary Arterial Hypertension Patients: An Expert Pulmonary Hypertension Clinician Perspective","volume":"4","author":"Hansen","year":"2018","journal-title":"Pulm. Ther."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1177\/0300060513490085","article-title":"N-terminal prohormone B-type natriuretic peptide and weaning outcome in post-operative patients with pulmonary complications","volume":"41","author":"Ma","year":"2013","journal-title":"J. Int. Med. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.healun.2022.10.003","article-title":"Risk stratification and response to therapy in patients with pulmonary arterial hypertension and comorbidities: A COMPERA analysis","volume":"42","author":"Rosenkranz","year":"2022","journal-title":"J. Hear. Lung Transplant."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.athoracsur.2007.04.006","article-title":"Brain natriuretic peptide as noninvasive marker of the severity of right ventricular dysfunction in chronic thromboembolic pulmonary hypertension","volume":"84","author":"Reesink","year":"2007","journal-title":"Ann. Thorac. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.clinbiochem.2004.06.002","article-title":"The natriuretic peptides and their role in disorders of right heart dysfunction and pulmonary hypertension","volume":"37","author":"Yap","year":"2004","journal-title":"Clin. Biochem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1097\/CCM.0000000000004617","article-title":"Fluid Overload and Mortality in Adult Critical Care Patients\u2014A Systematic Review and Meta-Analysis of Observational Studies*","volume":"48","author":"Messmer","year":"2020","journal-title":"Crit. Care Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1183\/09031936.00113009","article-title":"Noncardiothoracic nonobstetric surgery in mild-to-moderate pulmonary hypertension","volume":"35","author":"Price","year":"2010","journal-title":"Eur. Respir. J."},{"key":"ref_28","first-page":"239","article-title":"Surgical intervention in patients with moderate to severe pulmonary arterial hy-pertension","volume":"70","author":"Minai","year":"2006","journal-title":"Conn. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1097\/ALN.0b013e3181fc6e0a","article-title":"Prediction of postoperative pulmonary complications in a population-based surgical cohort","volume":"113","author":"Canet","year":"2010","journal-title":"Anesthesiology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1378\/chest.110.3.744","article-title":"Risk of pulmonary complications after elective abdominal surgery","volume":"110","author":"Lawrence","year":"1996","journal-title":"Chest"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S2213-2600(20)30317-9","article-title":"Pulmonary vascular resistance and clinical outcomes in patients with pulmonary hyper-tension: A retrospective cohort study","volume":"8","author":"Maron","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1378\/chest.10-0260","article-title":"Characterization of connective tissue disease-associated pulmonary arterial hypertension from REVEAL: Identifying systemic sclerosis as a unique phenotype","volume":"138","author":"Chung","year":"2010","journal-title":"Chest"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1093\/eurheartj\/ehac237","article-title":"2022 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"43","author":"Humbert","year":"2022","journal-title":"Eur. Heart J."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/7\/1996\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:20:51Z","timestamp":1760106051000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/7\/1996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,29]]},"references-count":33,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["jcm13071996"],"URL":"https:\/\/doi.org\/10.3390\/jcm13071996","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,29]]}}}