{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:02:14Z","timestamp":1780408934229,"version":"3.54.1"},"reference-count":46,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T00:00:00Z","timestamp":1711670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: This study comprehensively compared robotic pancreatic surgery with vascular resection (RPS-VR) to other surgical procedures in the treatment of pancreatic ductal adenocarcinoma (PDAC). (2) Methods: A systematic review of relevant literature was conducted to assess a range of crucial surgical and oncological outcomes. (3) Results: Findings indicate that robotic surgery with vascular resections (VRs) significantly prolongs the duration of surgery compared to other surgical procedures, and they notably demonstrate an equal hospital stay. While some studies reported a lower conversion rate and a higher rate of blood loss and blood transfusion in the RPS-VR group, others found no significant disparity. Furthermore, RPS-VR consistently correlated with comparable recurrence rates, free margins R0, postoperative mortality, and complication rates. Concerning the last one, certain reviews reported a higher rate of major complications. Overall survival and disease-free survival remained comparable between the RPS-VR and other surgical techniques in treating PDAC. (4) Conclusions: The analysis emphasizes how RPS-VR is a resembling approach in terms of surgical outcomes and aligns with existing literature findings in this field.<\/jats:p>","DOI":"10.3390\/jcm13072000","type":"journal-article","created":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T13:32:56Z","timestamp":1711891976000},"page":"2000","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Robotic Vascular Resection in Pancreatic Ductal Adenocarcinoma: A Systematic Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2948-3759","authenticated-orcid":false,"given":"Victoria","family":"Zecchin Ferrara","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Surgery, University of Padua, 35122 Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4016-534X","authenticated-orcid":false,"given":"Alessandro","family":"Martinino","sequence":"additional","affiliation":[{"name":"Department of Surgery, Duke University, Durham, NC 27708, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1617-5596","authenticated-orcid":false,"given":"Francesco","family":"Toti","sequence":"additional","affiliation":[{"name":"Department of Surgery, ASST Santi Paolo e Carlo, 20100 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9214-617X","authenticated-orcid":false,"given":"Davide","family":"Schilir\u00f2","sequence":"additional","affiliation":[{"name":"Department of Surgery, Duke University, Durham, NC 27708, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6376-2577","authenticated-orcid":false,"given":"Federico","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Illinois at Chicago, Chicago, IL 60607, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3392-9292","authenticated-orcid":false,"given":"Francesco","family":"Giovinazzo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00131 Rome, Italy"},{"name":"Department of Health Sciences, UniCamillus-Saint Camillus International University, 00131 Rome, Italy"},{"name":"Department of Surgery, Saint Camillus Hospital, 31100 Treviso, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the SMAGEICS Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ruarus, A., Vroomen, L., Puijk, R., Scheffer, H., and Meijerink, M. (2018). Locally Advanced Pancreatic Cancer: A Review of Local Ablative Therapies. Cancers, 10.","DOI":"10.3390\/cancers10010016"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1245\/s10434-017-5972-6","article-title":"Is Pancreatic Head Cancer with Portal Venous Involvement Really Borderline Resectable? Appraisal of an Upfront Surgery Series","volume":"24","author":"Ohgi","year":"2017","journal-title":"Ann. Surg. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/nrgastro.2009.177","article-title":"Epidemiology of pancreatic cancer: An overview","volume":"6","author":"Raimondi","year":"2009","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jamcollsurg.2013.11.017","article-title":"Portal Vein Resection in Borderline Resectable Pancreatic Cancer: A United Kingdom Multicenter Study","volume":"218","author":"Ravikumar","year":"2014","journal-title":"J. Am. Coll. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.surg.2008.12.009","article-title":"Portal or superior mesenteric vein resection for pancreatic head adenocarcinoma: Prognostic value of the length of venous resection","volume":"145","author":"Kaneoka","year":"2009","journal-title":"Surgery"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Satoi, S. (2021). Surgical Treatment of Pancreatic Ductal Adenocarcinoma. Cancers, 13.","DOI":"10.3390\/cancers13164015"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1007\/s11605-007-0216-x","article-title":"Vascular Resection and Reconstruction for Pancreatic Malignancy: A Single Center Survival Study","volume":"11","author":"Martin","year":"2007","journal-title":"J. Gastrointest. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/bjs.5368","article-title":"Systematic review of outcome of synchronous portal\u2013superior mesenteric vein resection during pancreatectomy for cancer","volume":"93","author":"Siriwardana","year":"2006","journal-title":"Br. J. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1002\/bjs.1800811126","article-title":"Portal vein resection in patients undergoing pancreatoduodenectomy for carcinoma of the pancreatic head","volume":"81","author":"Allema","year":"2005","journal-title":"Br. J. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1001\/archsurg.1989.01410010137027","article-title":"Clinical Experience with Regional Pancreatectomy for Adenocarcinoma of the Pancreas","volume":"124","author":"Sindelar","year":"1989","journal-title":"Arch. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1097\/SLA.0000000000001869","article-title":"A Multi-Institutional Comparison of Perioperative Outcomes of Robotic and Open Pancreaticoduodenectomy","volume":"264","author":"Zureikat","year":"2016","journal-title":"Ann. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1177\/1553350616646479","article-title":"Safety in Numbers: Progressive Implementation of a Robotics Program in an Academic Surgical Oncology Practice","volume":"23","author":"King","year":"2016","journal-title":"Surg. Innov."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.surg.2019.01.037","article-title":"Robotic pancreatoduodenectomy with vascular resection: Outcomes and learning curve","volume":"166","author":"Beane","year":"2019","journal-title":"Surgery"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e14204","DOI":"10.1097\/MD.0000000000014204","article-title":"Laparoscopic pancreatoduodenectomy combined with portal-superior mesenteric vein resection and reconstruction with interposition graft: Case series","volume":"98","author":"Wang","year":"2019","journal-title":"Medicine"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1007\/s00464-018-6044-0","article-title":"Laparoscopic pancreaticoduodenectomy with reconstruction of the mesentericoportal vein with the parietal peritoneum and the falciform ligament","volume":"32","author":"Dokmak","year":"2018","journal-title":"Surg. Endosc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s00423-016-1499-8","article-title":"Robotic pancreatoduodenectomy with vascular resection","volume":"401","author":"Kauffmann","year":"2016","journal-title":"Langenbecks Arch. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Kang, C.M., and Lee, W.J. (2020). Is Laparoscopic Pancreaticoduodenectomy Feasible for Pancreatic Ductal Adenocarcinoma?. 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Endosc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1097\/00000658-194506000-00008","article-title":"Pancreaticoduodenectomy for Islet Carcinoma: A Five-Year Follow-Up","volume":"121","author":"Whipple","year":"1945","journal-title":"Ann Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0039-6109(05)70460-6","article-title":"Laparoscopic Pancreatectomy","volume":"76","author":"Salky","year":"1996","journal-title":"Surg. Clin. N. Am."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1089\/109264203321235449","article-title":"Robotic Resection of Pancreatic Neuroendocrine Tumor","volume":"13","author":"Melvin","year":"2003","journal-title":"J. Laparoendosc. Adv. Surg. Tech."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/SLA.0000000000003590","article-title":"The Miami International Evidence-based Guidelines on Minimally Invasive Pancreas Resection","volume":"271","author":"Asbun","year":"2020","journal-title":"Ann. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s11701-021-01289-2","article-title":"Robotic pancreas surgery: An overview of history and update on technique, outcomes, and financials","volume":"16","author":"Khachfe","year":"2022","journal-title":"J. Robot. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.6004\/jnccn.2017.0131","article-title":"Pancreatic Adenocarcinoma, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology","volume":"15","author":"Tempero","year":"2017","journal-title":"J. Natl. Compr. Cancer Netw."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.pan.2017.11.011","article-title":"International consensus on definition and criteria of borderline resectable pancreatic ductal adenocarcinoma 2017","volume":"18","author":"Isaji","year":"2018","journal-title":"Pancreatology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.ijsu.2018.04.011","article-title":"Proposed Chaoyang vascular classification for superior mesenteric-portal vein invasion, resection, and reconstruction in patients with pancreatic head cancer during pancreaticoduodenectomy\u2014A retrospective cohort study","volume":"53","author":"Zhu","year":"2018","journal-title":"Int. J. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/1097-0142(195307)6:4<704::AID-CNCR2820060410>3.0.CO;2-P","article-title":"The coeliac axis in the expansion of the operation for gastric carcinoma","volume":"6","author":"Appleby","year":"1953","journal-title":"Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"j4008","DOI":"10.1136\/bmj.j4008","article-title":"AMSTAR 2: A critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both","volume":"358","author":"Shea","year":"2017","journal-title":"BMJ"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1136\/emermed-2020-209567","article-title":"Population, Intervention, Comparison, Outcomes and Study (PICOS) design as a framework to formulate eligibility criteria in systematic reviews","volume":"37","author":"Janati","year":"2020","journal-title":"Emerg. Med. J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1007\/s00423-021-02364-w","article-title":"Robotic versus open pancreaticoduodenectomy with vascular resection for pancreatic ductal adenocarcinoma: Surgical and oncological outcomes from pilot experience","volume":"407","author":"Jin","year":"2022","journal-title":"Langenbecks Arch. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.suronc.2020.08.025","article-title":"Robotic-assisted pancreaticoduodenectomy with vascular resection. Description of the surgical technique and analysis of early outcomes","volume":"35","author":"Marino","year":"2020","journal-title":"Surg. Oncol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"37","DOI":"10.21037\/ls-20-94","article-title":"Robot-assisted pancreaticoduodenectomy with vascular resection: Technical details and results from a high-volume center","volume":"4","author":"Kauffmann","year":"2020","journal-title":"Laparosc. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1007\/s11605-021-05043-9","article-title":"Robotic Resection and Reconstruction of the Superior Mesenteric Vein without Graft During Pancreatoduodenectomy (with Video)","volume":"25","author":"Machado","year":"2021","journal-title":"J. Gastrointest. Surg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s13304-020-00715-8","article-title":"Resection or repair of large peripancreatic arteries during robotic pancreatectomy","volume":"72","author":"Kauffmann","year":"2020","journal-title":"Updates Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1245\/s10434-022-13054-2","article-title":"Robot-Assisted Versus Laparoscopic Distal Pancreatectomy in Patients with Resectable Pancreatic Cancer: An International, Retrospective, Cohort Study","volume":"30","author":"Chen","year":"2023","journal-title":"Ann. Surg. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.surg.2009.04.029","article-title":"Prognostic implications of tumor invasion or adhesion to peripancreatic vessels in resected pancreatic cancer","volume":"146","author":"Boggi","year":"2009","journal-title":"Surgery"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1007\/s11605-008-0777-3","article-title":"Long Mesentericoportal Vein Resection and End-to-End Anastomosis without Graft in Pancreaticoduodenectomy","volume":"13","author":"Zhang","year":"2009","journal-title":"J. Gastrointest. Surg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1007\/s00464-022-09860-0","article-title":"Tips and tricks for robotic pancreatoduodenectomy with superior mesenteric\/portal vein resection and reconstruction","volume":"37","author":"Kauffmann","year":"2023","journal-title":"Surg. Endosc."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.surg.2014.02.001","article-title":"Borderline resectable pancreatic cancer: A consensus statement by the International Study Group of Pancreatic Surgery (ISGPS)","volume":"155","author":"Bockhorn","year":"2014","journal-title":"Surgery"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jss.2018.02.028","article-title":"The impact of unplanned conversion to an open procedure during minimally invasive pancreatectomy","volume":"227","author":"Stiles","year":"2018","journal-title":"J. Surg. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.jamcollsurg.2018.12.040","article-title":"Robotic Pancreaticoduodenectomy Is the Future: Here and Now","volume":"228","author":"Rosemurgy","year":"2019","journal-title":"J. Am. Coll. Surg."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e1277","DOI":"10.1097\/SLA.0000000000003664","article-title":"Learning Curve From 450 Cases of Robot-Assisted Pancreaticoduocectomy in a High-Volume Pancreatic Center: Optimization of Operative Procedure and a Retrospective Study","volume":"274","author":"Shi","year":"2021","journal-title":"Ann. Surg."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1007\/s00464-018-6595-0","article-title":"The learning curve for a surgeon in robot-assisted laparoscopic pancreaticoduodenectomy: A retrospective study in a high-volume pancreatic center","volume":"33","author":"Zhang","year":"2019","journal-title":"Surg. 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