{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T18:03:38Z","timestamp":1767981818409,"version":"3.49.0"},"reference-count":67,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T00:00:00Z","timestamp":1712188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background and Objectives: Antiseptics have been suggested to enhance the outcomes of non-surgical periodontal treatment (NSPT). Among these, povidone-iodine (PVP-iodine) was reported to significantly reduce periodontal pocket depths (PPDs). The aim of this study was to systematically re-assess the existing literature regarding the potential benefit of using PVP-iodine in step II periodontal therapy. Material and Methods: The scientific literature was systematically searched across electronic libraries for randomized controlled trials employing PVP-iodine during NSPT through to September 2023, using search items related to PVP-iodine and periodontitis. The selection process was performed by two independent reviewers. The primary outcomes were reductions in periodontal probing depth (PPD) and clinical attachment level (CAL). When reasonable, a meta-analysis of the included studies was performed. Results: Initially, 799 records were identified. After abstract and title screening and fulltext revision, 15 RCTs were included. The data from eight studies were merged in meta-analyses. The use of PVP-iodine had no significant effect on PPD reduction at 6 months (means [standard deviation]: \u22120.12 mm [\u22120.33; 0.09]) but it did at 12 months (\u22120.29 mm [\u22120.56; \u22120.02]). CAL was significantly better at 6 (\u22120.42 mm [\u22120.64; \u22120.20]) and 12 months (\u22120.39 mm [\u22120.66; \u22120.11]). Conclusions: PVP-iodine rinsing during NSPT may slightly improve patients\u2019 PPD and CAL.<\/jats:p>","DOI":"10.3390\/jcm13072111","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T10:42:03Z","timestamp":1712227323000},"page":"2111","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Rinsing with Povidone-Iodine during Step II Periodontal Therapy: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7290-2551","authenticated-orcid":false,"given":"Leonardo","family":"Svellenti","sequence":"first","affiliation":[{"name":"Department of Periodontology, Endodontology, and Cariology, University Center for Dental Medicine Basel UZB, University of Basel, 4058 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5078-2284","authenticated-orcid":false,"given":"Jelena","family":"Karacic","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Endodontology, and Cariology, University Center for Dental Medicine Basel UZB, University of Basel, 4058 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Herzog","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Endodontology, and Cariology, University Center for Dental Medicine Basel UZB, University of Basel, 4058 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moritz","family":"Tanner","sequence":"additional","affiliation":[{"name":"Clinic of Conservative and Preventive Dentistry, Center of Dental Medicine, University of Zurich, 8032 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Sahrmann","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Endodontology, and Cariology, University Center for Dental Medicine Basel UZB, University of Basel, 4058 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1111\/jcpe.12687","article-title":"Prevention and control of dental caries and periodontal diseases at individual and population level: Consensus report of group 3 of joint EFP\/ORCA workshop on the boundaries between caries and periodontal diseases","volume":"44","author":"Jepsen","year":"2017","journal-title":"J. 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