{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T22:31:12Z","timestamp":1774305072586,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Prognostic biomarkers may provide information about the patient\u2019s cardiovascular outcomes. However, there are doubts regarding how high-sensitivity C-reactive protein (hs-CRP) impacts patients with congenital heart disease (CHD). The main objective is to evaluate whether high hs-CRP levels predict a worse prognosis in patients with CHD. Methods: Observational and prospective cohort study. Adult CHD patients and controls were matched for age and sex. Results: In total, 434 CHD patients (cases) and 820 controls were studied. The median age in the CHD patients was 30 (18\u201362) years and 256 (59%) were male. A total of 51%, 30%, and 19% of patients with CHD had mild, moderate, and great complexity defects, respectively. The body mass index [1.07 (1.01\u20131.13), p = 0.022)], diabetes mellitus [3.57 (1.07\u201311.97), p = 0.039], high NT-pro-BNP levels [1.00 (1.00\u20131.01), p = 0.021], and low serum iron concentrations [0.98 (0.97\u20130.99), p = 0.001] predicted high hs-CRP levels (\u22650.3 mg\/dL) in patients with CHD. During a follow-up time of 6.81 (1.17\u201310.46) years, major cardiovascular events (MACE) occurred in 40 CHD patients, showing the Kaplan\u2013Meier test demonstrated a worse outcome among patients with hs-CRP levels above 0.3 mg\/dL (p = 0.012). Also, hs-CRP showed statistical significance in the univariate Cox regression survival analysis. However, after adjusting for other variables, this significance was lost and the remaining predictors of MACE were age [HR 1.03 (1.01\u20131.06), p = 0.001], great complexity defects [HR 2.46 (1.07\u20135.69), p = 0.035], and an NT pro-BNP cutoff value for heart failure &gt; 125 pg\/mL [HR 7.73 (2.54\u201323.5), p &lt; 0.001]. Conclusions: Hs-CRP obtained statistical significance in the univariate survival analysis. However, this significance was lost in the multivariate analysis in favor of age, CHD complexity, and heart failure.<\/jats:p>","DOI":"10.3390\/jcm13082199","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T03:29:04Z","timestamp":1712806144000},"page":"2199","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["C-Reactive Protein and Long-Term Prognosis in Adult Patients with Congenital Heart Disease"],"prefix":"10.3390","volume":"13","author":[{"given":"Efr\u00e9n","family":"Mart\u00ednez-Quintana","sequence":"first","affiliation":[{"name":"Cardiology Service, Complejo Hospitalario Universitario Insular-Materno Infantil, Avd. Mar\u00edtima del Sur s\/n, 35016 Las Palmas de Gran Canaria, Spain"},{"name":"Department of Medical and Surgical Sciences, Faculty of Health Sciences, Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Alc\u00e1ntara-Castellano","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Faculty of Health Sciences, Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta Isabel","family":"Garc\u00eda-Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Faculty of Health Sciences, Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fayna","family":"Rodr\u00edguez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Gran Canaria Dr. Negr\u00edn, 35010 Las Palmas de Gran Canaria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Majdalany, D.S. 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