{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:22:58Z","timestamp":1789507378453,"version":"build-2803163510"},"reference-count":157,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>In recent years, researchers have been interested in neuroprotective therapies as a cutting-edge therapeutic strategy to treat neurodegenerative disorders by shielding the brain system from harmful events. Millions of individuals worldwide suffer from glaucoma, an ocular neurodegenerative disease characterized by gradual excavation of the optic nerve head, retinal axonal damage, and consequent visual loss. The pathology\u2019s molecular cause is still mostly unknown, and the current treatments are not able to alter the disease\u2019s natural progression. Thus, the modern approach to treating glaucoma consists of prescribing medications with neuroprotective properties, in line with the treatment strategy suggested for other neurodegenerative diseases. For this reason, several naturally derived compounds, including nicotinamide and citicoline, have been studied throughout time to try to improve glaucoma management by exploiting their neuroprotective properties. The purpose of this review is to examine the naturally derived compounds that are currently utilized in clinical practice for neuroprotection in glaucomatous patients based on scientific data, emphasizing these compounds\u2019 pivotal mechanism of action as well as their proven therapeutic and neuroprotective benefits.<\/jats:p>","DOI":"10.3390\/jcm13082214","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T09:37:31Z","timestamp":1712828251000},"page":"2214","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Optic Nerve Neuroprotection in Glaucoma: A Narrative Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2981-3122","authenticated-orcid":false,"given":"Angela","family":"D\u2019Angelo","sequence":"first","affiliation":[{"name":"Department of Medicine and Surgery, University of Naples \u201cFederico II\u201d, 80138 Naples, NA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7867-3342","authenticated-orcid":false,"given":"Livio","family":"Vitiello","sequence":"additional","affiliation":[{"name":"Eye Unit, \u201cLuigi Curto\u201d Hospital, Azienda Sanitaria Locale Salerno, 84035 Polla, SA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0956-4925","authenticated-orcid":false,"given":"Filippo","family":"Lixi","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Surgical Sciences, University of Cagliari, 09124 Cagliari, CA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Abbinante","sequence":"additional","affiliation":[{"name":"Eye Unit, \u201cLuigi Curto\u201d Hospital, Azienda Sanitaria Locale Salerno, 84035 Polla, SA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Coppola","sequence":"additional","affiliation":[{"name":"Eye Unit, \u201cLuigi Curto\u201d Hospital, Azienda Sanitaria Locale Salerno, 84035 Polla, SA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Gagliardi","sequence":"additional","affiliation":[{"name":"Eye Unit, \u201cLuigi Curto\u201d Hospital, Azienda Sanitaria Locale Salerno, 84035 Polla, SA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Pellegrino","sequence":"additional","affiliation":[{"name":"Eye Unit, \u201cLuigi Curto\u201d Hospital, Azienda Sanitaria Locale Salerno, 84035 Polla, SA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2617-0289","authenticated-orcid":false,"given":"Giuseppe","family":"Giannaccare","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Surgical Sciences, University of Cagliari, 09124 Cagliari, CA, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101225","DOI":"10.1016\/j.mam.2023.101225","article-title":"Novel frontiers in neuroprotective therapies in glaucoma: Molecular and clinical aspects","volume":"94","author":"Boccaccini","year":"2023","journal-title":"Mol. 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