{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:55:00Z","timestamp":1787889300395,"version":"build-2784847793"},"reference-count":48,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3 La Marat\u00f3 TV3 2018 603\/C\/2019","award":["201912-30-31"],"award-info":[{"award-number":["201912-30-31"]}]},{"name":"Fundaci\u00f3 La Marat\u00f3 TV3 2018 603\/C\/2019","award":["CP21\/00058"],"award-info":[{"award-number":["CP21\/00058"]}]},{"name":"Miguel Servet Program","award":["201912-30-31"],"award-info":[{"award-number":["201912-30-31"]}]},{"name":"Miguel Servet Program","award":["CP21\/00058"],"award-info":[{"award-number":["CP21\/00058"]}]},{"name":"Instituto de Salud Carlos III","award":["201912-30-31"],"award-info":[{"award-number":["201912-30-31"]}]},{"name":"Instituto de Salud Carlos III","award":["CP21\/00058"],"award-info":[{"award-number":["CP21\/00058"]}]},{"name":"European Union","award":["201912-30-31"],"award-info":[{"award-number":["201912-30-31"]}]},{"name":"European Union","award":["CP21\/00058"],"award-info":[{"award-number":["CP21\/00058"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Identifying biomarkers linked to pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP) is crucial for early detection, treatment, and prevention. Methods: Association analyses of 10 serological biomarkers involved in cell signalling (IFN-\u03b3, IL-6, IL-8, IL-10), oxidative stress (superoxide dismutase (SOD) and glutathione peroxidase (GPx) enzyme activities, total glutathione (GSH), malondialdehyde (MDA) levels), and intestinal permeability proteins (zonulin, I-FABP2) were conducted across PDAC (n = 12), CP (n = 21) and control subjects (n = 23). A Mendelian randomisation (MR) approach was used to assess causality of the identified significant associations in two large genetic cohorts (FinnGen and UK Biobank). Results: Observational results showed a downregulation of SOD and GPx antioxidant enzyme activities in PDAC and CP patients, respectively, and higher MDA levels in CP patients. Logistic regression models revealed significant associations between CP and SOD activity (OR = 0.21, 95% CI [0.05, 0.89], per SD), GPx activity (OR = 0.28, 95% CI [0.10, 0.79], per SD), and MDA levels (OR = 2.05, 95% CI [1.36, 3.08], per SD). MR analyses, however, did not support causality. Conclusions: These findings would not support oxidative stress-related biomarkers as potential targets for pancreatic diseases prevention. Yet, further research is encouraged to assess their viability as non-invasive tools for early diagnosis, particularly in pre-diagnostic CP populations.<\/jats:p>","DOI":"10.3390\/jcm13082247","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T09:28:06Z","timestamp":1712914086000},"page":"2247","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring the Associations of Inflammatory and Oxidative Stress Biomarkers with Pancreatic Diseases: An Observational and Mendelian Randomisation Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7495-0031","authenticated-orcid":false,"given":"Laura","family":"Vil\u00e0-Quintana","sequence":"first","affiliation":[{"name":"Digestive Diseases and Microbiota Group, Department of Gastroenterology, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr. Josep Trueta, 17190 Salt, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Fort","sequence":"additional","affiliation":[{"name":"Digestive Diseases and Microbiota Group, Department of Gastroenterology, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr. Josep Trueta, 17190 Salt, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pardo","sequence":"additional","affiliation":[{"name":"Digestive Diseases and Microbiota Group, Department of Gastroenterology, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr. Josep Trueta, 17190 Salt, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria T.","family":"Albiol-Quer","sequence":"additional","affiliation":[{"name":"General and Digestive Surgery Group, Department of Surgery, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr. Josep Trueta, 17007 Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8973-0493","authenticated-orcid":false,"given":"Maria Rosa","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Universitari de Girona Dr. Josep Trueta, 17007 Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0649-9773","authenticated-orcid":false,"given":"Montserrat","family":"Capdevila","sequence":"additional","affiliation":[{"name":"Digestive Diseases and Microbiota Group, Department of Gastroenterology, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr. Josep Trueta, 17190 Salt, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Feliu","sequence":"additional","affiliation":[{"name":"Digestive Diseases and Microbiota Group, Department of Gastroenterology, Girona Biomedical Research Institute (IDIBGI), Hospital 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Digestive Diseases and Microbiota Group, Department of Gastroenterology, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr. Josep Trueta, 17190 Salt, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8388-0522","authenticated-orcid":false,"given":"Adelaida","family":"Garc\u00eda-Velasco","sequence":"additional","affiliation":[{"name":"Precision Oncology Group, Girona Biomedical Research Institute (IDIBGI), Institut Catal\u00e0 d\u2019Oncologia (ICO), Hospital Universitari de Girona Dr. Josep Trueta, 17007 Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1708-0110","authenticated-orcid":false,"given":"Mireia M.","family":"Ginest\u00e0","sequence":"additional","affiliation":[{"name":"Hereditary Cancer 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Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2818-5487","authenticated-orcid":false,"given":"Victor","family":"Moreno","sequence":"additional","affiliation":[{"name":"Catalan Institute of Oncology (ICO), Institut de Recerca Biomedica de Bellvitge (IDIBELL), 08908 Barcelona, Spain"},{"name":"Department of Clinical Sciences, Faculty of Medicine and health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), University of Barcelona (UB), L\u2019Hospitalet de Llobregat, 08028 Barcelona, Spain"},{"name":"Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libadro Jes\u00fas","family":"Garcia-Gil","sequence":"additional","affiliation":[{"name":"Digestive Diseases and Microbiota Group, Department of Gastroenterology, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr. 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