{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:57:09Z","timestamp":1790963829750,"version":"4.1.0"},"reference-count":63,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T00:00:00Z","timestamp":1713052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Romanian Operational Program for Competitiveness 2014\u20132020, Axis 1, under POC\/448\/1\/1 Research Infrastructure Projects for Public R&amp;D Institutions\/Universities \u201cMultidisciplinary Medical Research-Development Platform in the NE region\u201dCENEMED","award":["127606"],"award-info":[{"award-number":["127606"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: As the life expectancy of patients with myasthenia gravis (MG) is improving, so the number of comorbidities continues to rise, with a potentially significant impact on the overall morbidity and mortality. The main aim of the study was to assess comorbidities of MG in a group of patients of East-European descent. Methods: We retrospectively compared 185 adult myasthenic patients with 895 sex- and age-matched controls, admitted from January 2013 to December 2021. Results: Of these patients, 60% had late-onset MG (LOMG), with a clear predominance of women in both the LOMG and early-onset (EOMG) types; and 23.8% of the patients had a radiological description consistent with thymoma. All myasthenic patients had at least one comorbidity; 20 (10.8%) of the patients associated at least one autoimmune comorbidity. Obesity (p &lt; 0.01), type 2 diabetes (p &lt; 0.0001), cerebrovascular diseases (p &lt; 0.0001), essential hypertension (p &lt; 0.01), and cardiac arrythmias (p &lt; 0.0001) were more frequent in patients than in the control group. The granulocyte-to-lymphocyte ratio was higher in the myasthenic patients compared to the controls (p &lt; 0.01 for LOMG). Discussion: We, thus, suggest a common chronic low-grade inflammatory background as a possible connection between MG subtypes and some of these apparently unconnected comorbidities. Conclusions: The East-European origin of the patients offered a different social and cultural angle of a disease studied mainly on populations of West-European and Asian descent.<\/jats:p>","DOI":"10.3390\/jcm13082273","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T08:08:12Z","timestamp":1713168492000},"page":"2273","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Autoimmune and Non-Autoimmune Comorbidities in Myasthenic Patients of East-European Descent: A Case\u2013Control Study"],"prefix":"10.3390","volume":"13","author":[{"given":"Cristina Georgiana","family":"Croitoru","sequence":"first","affiliation":[{"name":"I Neurology Clinic, \u201cProf. Dr. Nicolae Oblu\u201d Emergency Clinical Hospital, 700309 Ia\u0219i, Romania"},{"name":"Department of Immunology, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2802-5993","authenticated-orcid":false,"given":"Mariana","family":"Pavel-Tanasa","sequence":"additional","affiliation":[{"name":"Department of Immunology, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan Iulian","family":"Cuciureanu","sequence":"additional","affiliation":[{"name":"I Neurology Clinic, \u201cProf. Dr. Nicolae Oblu\u201d Emergency Clinical Hospital, 700309 Ia\u0219i, Romania"},{"name":"Department Medical III, Discipline of Neurology, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Nicoleta","family":"Hodorog","sequence":"additional","affiliation":[{"name":"I Neurology Clinic, \u201cProf. Dr. Nicolae Oblu\u201d Emergency Clinical Hospital, 700309 Ia\u0219i, Romania"},{"name":"Department Medical III, Discipline of Neurology, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5403-2265","authenticated-orcid":false,"given":"Petru","family":"Cianga","sequence":"additional","affiliation":[{"name":"Department of Immunology, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/cei.12217","article-title":"Myasthenia gravis: An update for the clinician","volume":"175","author":"Sieb","year":"2014","journal-title":"Clin. Exp. 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