{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T19:36:14Z","timestamp":1788550574239,"version":"build-2803163510"},"reference-count":48,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T00:00:00Z","timestamp":1713398400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: We aimed to evaluate whether the administration of remimazolam as a maintenance agent for general anesthesia affects the occurrence of hypotension compared with sevoflurane when switching to the beach chair position (BCP). Methods: We conducted a prospective randomized controlled trial from June 2023 to October 2023 in adult patients undergoing orthopedic surgery under general anesthesia in the BCP. A total of 78 participants were randomly allocated to the remimazolam (R) or sevoflurane (S) groups. The primary outcome was the incidence of hypotension that occurred immediately after switching to a BCP. The secondary outcomes included differences between the study groups in perioperative blood pressure (BP), heart rate (HR), endotracheal tube extubation time, postoperative complications, and hospital length of stay (LOS). Results: The incidence of hypotension immediately after switching to a BCP was significantly higher in the S group. The risk factors associated with hypotension included sevoflurane administration and a high baseline systolic BP. In the receiver operating characteristic curve analysis for the occurrence of hypotension after the transition to a BCP, the cutoff value for systolic BP was 142 mmHg. The perioperative BP and HR were higher in the R group at several timepoints. Postoperative endotracheal tube extubation time was shorter in the R group. There were no significant differences in the postoperative complications or hospital LOS between the two groups. Conclusions: Remimazolam should be considered as an anesthetic agent to prevent hypotension when switching to BCP, and hypotension may occur frequently in patients with high baseline BP.<\/jats:p>","DOI":"10.3390\/jcm13082364","type":"journal-article","created":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T10:30:52Z","timestamp":1713436252000},"page":"2364","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comparison of Hemodynamic Parameters Based on the Administration of Remimazolam or Sevoflurane in Patients under General Anesthesia in the Beach Chair Position: A Single-Blinded Randomized Controlled Trial"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5943-7715","authenticated-orcid":false,"given":"Sangho","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimung","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2884-3977","authenticated-orcid":false,"given":"Doh Yoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YoungYun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7506-1375","authenticated-orcid":false,"given":"Hee Yong","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1995-1220","authenticated-orcid":false,"given":"Jeong-Hyun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5859-9808","authenticated-orcid":false,"given":"Youngsoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Kyeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8775-5582","authenticated-orcid":false,"given":"Ann Hee","family":"You","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3389\/fphys.2014.00187","article-title":"Cardiovascular consequence of reclining vs. sitting beach-chair body position for induction of anesthesia","volume":"5","author":"Larsen","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.arthro.2014.05.008","article-title":"Outcomes of arthroscopic anterior shoulder instability in the beach chair versus lateral decubitus position: A systematic review and meta-regression analysis","volume":"30","author":"Frank","year":"2014","journal-title":"J. Arthrosc. Relat. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Kim, N., Kim, K.H., Choi, Y.S., Song, S.H., and Choi, S.H. (2022). Effect of Dexmedetomidine on Early Postoperative Cognitive Function in Patients Undergoing Arthroscopic Shoulder Surgery in Beach Chair Position: A Randomized Double-Blind Study. J. Clin. Med., 11.","DOI":"10.3390\/jcm11112970"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1213\/ANE.0000000000004133","article-title":"Safety of Beach Chair Position Shoulder Surgery: A Review of the Current Literature","volume":"129","author":"Murphy","year":"2019","journal-title":"Anesth. Analg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1213\/ANE.0000000000006200","article-title":"Effects of Goal-Directed Hemodynamic Therapy Using a Noninvasive Finger-Cuff Monitoring Device on Intraoperative Cerebral Oxygenation and Early Delayed Neurocognitive Recovery in Patients Undergoing Beach Chair Position Shoulder Surgery: A Randomized Controlled Trial","volume":"136","author":"Lee","year":"2023","journal-title":"Anesth. Analg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jclinane.2018.09.035","article-title":"The beach chair position for shoulder surgery in intravenous general anesthesia and controlled hypotension: Impact on cerebral oxygenation, cerebral blood flow and neurobehavioral outcome","volume":"53","author":"Aguirre","year":"2019","journal-title":"J. Clin. Anesth."},{"key":"ref_7","first-page":"702","article-title":"Fluid preloading before beach chair positioning for arthroscopic shoulder procedures: A randomized controlled trial","volume":"72","author":"Gokduman","year":"2022","journal-title":"Braz. J. Anesthesiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"109661","DOI":"10.1016\/j.jclinane.2019.109661","article-title":"Effects of remote ischemic preconditioning on regional cerebral oxygen saturation in patients in the beach chair position during shoulder surgery: A double-blind randomized controlled trial","volume":"61","author":"Oh","year":"2020","journal-title":"J. Clin. Anesth."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.17085\/apm.21115","article-title":"Remimazolam: Pharmacological characteristics and clinical applications in anesthesiology","volume":"17","author":"Kim","year":"2022","journal-title":"Anesth. Pain. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"690875","DOI":"10.3389\/fphar.2021.690875","article-title":"Remimazolam: Non-Clinical and Clinical Profile of a New Sedative\/Anesthetic Agent","volume":"12","author":"Kilpatrick","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0165-6147(97)90675-1","article-title":"The benzodiazepine binding site of GABAA receptors","volume":"18","author":"Sigel","year":"1997","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/01.anes.0000267503.85085.c0","article-title":"CNS 7056: A novel ultra-short-acting Benzodiazepine","volume":"107","author":"Kilpatrick","year":"2007","journal-title":"Anesthesiology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1213\/ANE.0b013e3182a705ae","article-title":"A phase Ib, dose-finding study of multiple doses of remimazolam (CNS 7056) in volunteers undergoing colonoscopy","volume":"117","author":"Worthington","year":"2013","journal-title":"Anesth. Analg."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Lee, B., Kim, M.H., Kong, H.J., Shin, H.J., Yang, S., Kim, N.Y., and Chae, D. (2022). Effects of Remimazolam vs. Sevoflurane Anesthesia on Intraoperative Hemodynamics in Patients with Gastric Cancer Undergoing Robotic Gastrectomy: A Propensity Score-Matched Analysis. J. Clin. Med., 11.","DOI":"10.3390\/jcm11092643"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"938940","DOI":"10.3389\/fmed.2022.938940","article-title":"The hemodynamic stability of remimazolam compared with propofol in patients undergoing endoscopic submucosal dissection: A randomized trial","volume":"9","author":"Qiu","year":"2022","journal-title":"Front. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/ALN.0000000000003260","article-title":"Individualized Fluid Management Using the Pleth Variability Index: A Randomized Clinical Trial","volume":"133","author":"Fischer","year":"2020","journal-title":"Anesthesiology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1093\/bja\/aen133","article-title":"Pleth variability index to monitor the respiratory variations in the pulse oximeter plethysmographic waveform amplitude and predict fluid responsiveness in the operating theatre","volume":"101","author":"Cannesson","year":"2008","journal-title":"Br. J. Anaesth."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1213\/ANE.0b013e3181eb624f","article-title":"Goal-directed fluid management based on the pulse oximeter-derived pleth variability index reduces lactate levels and improves fluid management","volume":"111","author":"Forget","year":"2010","journal-title":"Anesth. Analg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"c179","DOI":"10.1159\/000339789","article-title":"KDIGO clinical practice guidelines for acute kidney injury","volume":"120","author":"Khwaja","year":"2012","journal-title":"Nephron. Clin. Pract."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/bja\/aex002","article-title":"Postoperative pulmonary complications","volume":"118","author":"Miskovic","year":"2017","journal-title":"Br. J. Anaesth."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Lee, S., Kang, H.Y., Ahn, Y.N., and You, A.H. (2023). Comparison of the Incidence of Postoperative Acute Kidney Injury Following the Administration of Remimazolam or Sevoflurane in Elderly Patients Undergoing Total Knee Arthroplasty: A Randomized Controlled Trial. J. Pers. Med., 13.","DOI":"10.3390\/jpm13050789"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1288243","DOI":"10.3389\/fmed.2023.1288243","article-title":"Comparison of oxygen reserve index according to the remimazolam or dexmedetomidine for intraoperative sedation under regional anesthesia\u2014A single-blind randomized controlled trial","volume":"10","author":"Lee","year":"2023","journal-title":"Front. Med."},{"key":"ref_23","first-page":"1","article-title":"Comparison of remimazolam-based and propofol-based total intravenous anesthesia on hemodynamics during anesthesia induction in patients undergoing transcatheter aortic valve replacement: A randomized controlled trial","volume":"12","author":"Kotani","year":"2024","journal-title":"J. Anesth."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Huang, Y., Yan, T., Lu, G., Luo, H., Lai, Z., and Zhang, L. (2023). Efficacy and safety of remimazolam compared with propofol in hypertensive patients undergoing breast cancer surgery: A single-center, randomized, controlled study. BMC Anesthesiol., 23.","DOI":"10.1186\/s12871-023-02364-x"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"101337","DOI":"10.1016\/j.accpm.2023.101337","article-title":"Comparison between remimazolam and propofol anaesthesia for interventional neuroradiology: A randomised controlled trial","volume":"43","author":"Lee","year":"2023","journal-title":"Anaesth. Crit. Care Pain Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e13521","DOI":"10.1111\/ijcp.13521","article-title":"A retrospective cohort analysis for the risk factors of intraoperative hypotension","volume":"74","author":"Dai","year":"2020","journal-title":"Int. J. Clin. Pract."},{"key":"ref_27","first-page":"7044","article-title":"A systematic review of risk factors for postinduction hypotension in surgical patients undergoing general anesthesia","volume":"25","author":"Chen","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00540-018-2532-6","article-title":"Hypotension after induction of general anesthesia: Occurrence, risk factors, and therapy. A prospective multicentre observational study","volume":"32","author":"Jor","year":"2018","journal-title":"J. Anesth."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/bja\/aes313","article-title":"Influence of preoperative anxiety on hypotension after spinal anaesthesia in women undergoing Caesarean delivery","volume":"109","author":"Ginosar","year":"2012","journal-title":"Br. J. Anaesth."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"868","DOI":"10.29271\/jcpsp.2019.09.868","article-title":"Effects of Preoperative Anxiety on Intraoperative Hemodynamics and Postoperative Pain","volume":"29","author":"Bayrak","year":"2019","journal-title":"J. Coll. Physicians Surg. Pak. JCPSP"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4097\/kja.19493","article-title":"Risk factors associated with hypotensive bradycardic events during open shoulder surgery in the beach chair position","volume":"74","author":"Choi","year":"2021","journal-title":"Korean J. Anesthesiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.arthro.2018.10.123","article-title":"Risk Factors for Cerebral Desaturation Events During Shoulder Surgery in the Beach Chair Position","volume":"35","author":"Gilotra","year":"2019","journal-title":"J. Arthrosc. Relat. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1097\/CORR.0000000000001864","article-title":"What Is the Risk of Intraoperative Cerebral Oxygen Desaturation in Patients Undergoing Shoulder Surgery in the Beach Chair Position?","volume":"479","author":"Thanaboriboon","year":"2021","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e652","DOI":"10.1016\/j.wneu.2022.03.102","article-title":"Risk Factors for Intraoperative Hypotension During Decompressive Craniectomy in traumatic Brain Injury Patients","volume":"162","author":"Saengrung","year":"2022","journal-title":"World Neurosurg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jjcc.2021.03.010","article-title":"Risk factors including preoperative echocardiographic parameters for post-induction hypotension in general anesthesia","volume":"78","author":"Tarao","year":"2021","journal-title":"J. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1213\/01.ANE.0000175214.38450.91","article-title":"Predictors of hypotension after induction of general anesthesia","volume":"101","author":"Reich","year":"2005","journal-title":"Anesth. Analg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10877-017-0038-7","article-title":"Pre-anesthetic stroke volume variation can predict cardiac output decrease and hypotension during induction of general anesthesia","volume":"32","author":"Juri","year":"2018","journal-title":"J. Clin. Monit. Comput."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Kim, H.J., Kim, J.Y., Park, H.S., Kim, H., Ro, Y.J., and Koh, W.U. (2024). Effect of Remimazolam- versus Propofol-Based Total Intravenous General Anesthesia on Intraoperative Hemodynamic Stability for Major Spine Surgery in the Prone Position: A Randomized Controlled Trial. Medicina, 60.","DOI":"10.3390\/medicina60030432"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/bja\/aes373","article-title":"Pleth variability index is a weak predictor of fluid responsiveness in patients receiving norepinephrine","volume":"110","author":"Monnet","year":"2013","journal-title":"Br. J. Anaesth."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s10877-015-9821-5","article-title":"Prediction of fluid responsiveness in the beach chair position using dynamic preload indices","volume":"30","author":"Lee","year":"2016","journal-title":"J. Clin. Monit. Comput."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Wu, Q., Xu, F., Wang, J., and Jiang, M. (2023). Comparison of Remimazolam-Flumazenil versus Propofol for Recovery from General Anesthesia: A Systematic Review and Meta-Analysis. J. Clin. Med., 12.","DOI":"10.3390\/jcm12237316"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e36081","DOI":"10.1097\/MD.0000000000036081","article-title":"Remimazolam-based anesthesia with flumazenil allows faster emergence than propofol-based anesthesia in older patients undergoing spinal surgery: A randomized controlled trial","volume":"102","author":"Toyota","year":"2023","journal-title":"Medicine"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1007\/s12325-023-02615-w","article-title":"Remimazolam Compared to Propofol for Total Intravenous Anesthesia with Remifentanil on the Recovery of Psychomotor Function: A Randomized Controlled Trial","volume":"40","author":"Shimizu","year":"2023","journal-title":"Adv. Ther."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"252","DOI":"10.17085\/apm.22252","article-title":"Comparison of remimazolam-remifentanil and propofol-remifentanil during laparoscopic cholecystectomy","volume":"18","author":"Lee","year":"2023","journal-title":"Anesth. Pain Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1265860","DOI":"10.3389\/fmed.2023.1265860","article-title":"Safety and efficacy of remimazolam for general anesthesia in elderly patients undergoing laparoscopic cholecystectomy: A randomized controlled trial","volume":"10","author":"So","year":"2023","journal-title":"Front. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"E537","DOI":"10.1503\/cmaj.160357","article-title":"Flumazenil in benzodiazepine overdose","volume":"188","author":"An","year":"2016","journal-title":"Can. Med. Assoc. J."},{"key":"ref_47","first-page":"Cd012317","article-title":"Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery","volume":"8","author":"Miller","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"631","DOI":"10.2147\/DDDT.S444313","article-title":"Clinical Study of Flumazenil Antagonizing Remimazolam on Nausea and Vomiting After Gynecologic Day Surgery","volume":"18","author":"Wei","year":"2024","journal-title":"Drug Des. Dev. Ther."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/8\/2364\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:30:12Z","timestamp":1760106612000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/8\/2364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,18]]},"references-count":48,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,4]]}},"alternative-id":["jcm13082364"],"URL":"https:\/\/doi.org\/10.3390\/jcm13082364","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,18]]}}}