{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:02:57Z","timestamp":1792605777372,"version":"4.5.0"},"reference-count":40,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T00:00:00Z","timestamp":1713484800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Linezolid is used for Gram-positive bacterial infections. Thrombocytopenia is one of its main adverse effects resulting from myelosuppression. Several studies have assessed risk factors that may increase the risk of this adverse effect. However, most studies included patients with hemato-oncologic diseases, which may confound such assessments. This study aimed to investigate risk factors for linezolid-associated thrombocytopenia in patients without hemato-oncologic diseases. Methods: This was a multicenter retrospective case-control study of adult patients treated with linezolid twice daily for \u22653 days. Patients with hemato-oncologic diseases, active dengue fever, active COVID-19, baseline platelet count &lt;100 \u00d7 103\/mm3, concurrent therapy with trimethoprim\/sulfamethoxazole or valproic acid, and a recent platelet transfusion within 7 days were excluded. Thrombocytopenia was defined as a drop in platelet count below 100 \u00d7 103\/mm3. Results: Out of 158 evaluated patients, 33 developed thrombocytopenia, indicating an incidence rate of 20.9%. Of all the risk factors assessed, creatinine clearance of &lt;60 mL\/min and bacteremia\/infective endocarditis were significantly associated with linezolid-associated thrombocytopenia (adjusted odds ratios, 3.25 and 5.95; 95% CI 1.12\u20139.45 and 1.23\u201328.66; p = 0.031 and 0.026, respectively). End of therapy platelet counts were significantly lower in the cases than in the controls (79 vs. 243 \u00d7 103\/mm3; p &lt; 0.001). Similarly, the percentage of platelet count change was significantly different (\u221255.1% vs. \u221210.2%; p &lt; 0.001). Conclusions: In our study, the incidence rate of linezolid-associated thrombocytopenia was 20.9%, and we found that patients with renal impairment and bacteremia may need close monitoring of platelet counts. Prospective studies are warranted to evaluate the potential need for renal dose adjustment.<\/jats:p>","DOI":"10.3390\/jcm13082380","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T06:28:09Z","timestamp":1713508089000},"page":"2380","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Linezolid-Associated Thrombocytopenia: Assessment of Risk Factors in Patients without Hemato-Oncologic Diseases"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0369-9094","authenticated-orcid":false,"given":"Abrar K.","family":"Thabit","sequence":"first","affiliation":[{"name":"Pharmacy Practice Department, Faculty of Pharmacy, King Abdulaziz University, Jeddah 22254-2265, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arwa A.","family":"Alghamdi","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, King Abdulaziz University, Jeddah 22254-2265, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afnan K.","family":"Alsaeed","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, King Abdulaziz University, Jeddah 22254-2265, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesereen M.","family":"Magbool","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, King Abdulaziz University, Jeddah 22254-2265, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0450-9846","authenticated-orcid":false,"given":"Yazed S.","family":"Alsowaida","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, College of Pharmacy, University of Ha\u2019il, Hail 55473, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7140-741X","authenticated-orcid":false,"given":"Ahmad J.","family":"Mahrous","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy Department, College of Pharmacy, Umm Al Qura University, Makkah 21955, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9705-0183","authenticated-orcid":false,"given":"Alya","family":"Alruwaili","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Care, King Fahad Medical City, Riyadh 12231, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyad K.","family":"Albakistani","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Umm Al Qura University, Makkah 21955, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basem O.","family":"Albangali","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Umm Al Qura University, Makkah 21955, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas M.","family":"Alghumuy","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Umm Al Qura University, Makkah 21955, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara A.","family":"Youssef","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Care, Saudi German Hospital, Hail 55481, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem M.","family":"Alodayli","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Care, Saudi German Hospital, Hail 55481, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6531-4877","authenticated-orcid":false,"given":"Masaad Saeed","family":"Almutairi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy, Qassim University, Qassim 51452, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.2147\/DDDT.S164515","article-title":"Linezolid: A review of its properties, function, and use in critical care","volume":"12","author":"Hashemian","year":"2018","journal-title":"Drug Des. 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