{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:36:59Z","timestamp":1764333419989,"version":"build-2065373602"},"reference-count":26,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T00:00:00Z","timestamp":1713657600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: A higher prevalence of ophthalmological alterations in systemic inflammatory diseases has been demonstrated. Objectives: Our objectives were to determine anterior segment findings and corneal properties in alopecia areata (AA). Methods: This is a case-control study. Severe AA patients (Severity of Alopecia Tool &gt; 50%) and non-AA subjects underwent a general ophthalmological examination, a Pentacam and Corvis scheimpflug technology examination (Oculus Optikger\u00e4te GmbH, Wetzlar, Germany). Visual acuity, refractive error, corneal aesthesiometry, and biomechanical and topographic variables were registered. Results: In total, 25 AA patients (50 eyes; 50.6 \u00b1 8.1 years) and 29 controls (58 eyes; 49.4 \u00b1 8.6 years) were included. AA patients had decreased corneal sensitivity, more corneal staining, and a more advanced cataract (p \u2264 0.004). The anterior topographic flat meridian, mean anterior keratometry, and maximum keratometric point were increased in AA (p \u2264 0.040), while pachymetry values were thinner (p \u2264 0.001). Keratoconus index and Belin\/Ambrosio-enhanced ectasia total deviation display were increased (p \u2264 0.007). Two eyes with a topographic diagnosis of keratoconus and four eyes with subclinical keratoconus were detected in AA. Applanation lengths were smaller in AA (p \u2264 0.029). The Corvis Biomechanical Index was increased in AA (p = 0.022). Conclusions: AA patients have reduced corneal sensitivity and increased corneal staining. Topographic and biomechanical parameters are altered, and there could be a higher risk of keratoconus, thus possibly requiring routine ophthalmological examination.<\/jats:p>","DOI":"10.3390\/jcm13082426","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T06:10:18Z","timestamp":1713766218000},"page":"2426","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Alterations in Corneal Sensitivity, Staining and Biomechanics of Alopecia Areata Patients: Novel Findings in a Case-Control Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2178-6164","authenticated-orcid":false,"given":"Barbara","family":"Burgos-Blasco","sequence":"first","affiliation":[{"name":"Ophthalmology Department, Instituto de Investigaci\u00f3n Sanitaria, Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4517-507X","authenticated-orcid":false,"given":"Patricia","family":"Burgos-Blasco","sequence":"additional","affiliation":[{"name":"Trichology Unit, Dermatology Department, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria\u2014IRYCIS, Ramon y Cajal Hospital, 28034 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5742-8911","authenticated-orcid":false,"given":"Olivia","family":"Rodriguez-Quet","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Instituto de Investigaci\u00f3n Sanitaria, Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Arriola-Villalobos","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Instituto de Investigaci\u00f3n Sanitaria, Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"},{"name":"Departamento de Inmunolog\u00eda, Oftalmolog\u00eda y ORL, Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8745-3464","authenticated-orcid":false,"given":"Jose Ignacio","family":"Fernandez-Vigo","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Instituto de Investigaci\u00f3n Sanitaria, Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6315-5462","authenticated-orcid":false,"given":"David","family":"Saceda-Corralo","sequence":"additional","affiliation":[{"name":"Trichology Unit, Dermatology Department, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria\u2014IRYCIS, Ramon y Cajal Hospital, 28034 Madrid, Spain"},{"name":"Grupo Pedro Jaen Clinic, 28002 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Va\u00f1o-Galvan","sequence":"additional","affiliation":[{"name":"Trichology Unit, Dermatology Department, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria\u2014IRYCIS, Ramon y Cajal Hospital, 28034 Madrid, Spain"},{"name":"Grupo Pedro Jaen Clinic, 28002 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juli\u00e1n","family":"Garc\u00eda-Feij\u00f3o","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Instituto de Investigaci\u00f3n Sanitaria, Hospital Cl\u00ednico San Carlos (IdISSC), 28040 Madrid, Spain"},{"name":"Departamento de Inmunolog\u00eda, Oftalmolog\u00eda y ORL, Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1001\/archderm.1992.01680150136027","article-title":"Prevalence of alopecia areata in the First National Health and Nutrition Examination Survey","volume":"128","author":"Safavi","year":"1992","journal-title":"Arch. 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