{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:53:30Z","timestamp":1792050810789,"version":"4.4.0"},"reference-count":23,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Society of Diabetic Neuropathy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Lower extremity amputations (LEAs) are a burdensome complication of peripheral artery disease (PAD) and\/or arterial embolism and thrombosis (AET). We assessed the trends in PAD- and\/or AET-related LEAs in Romania. Methods: This retrospective study (2015\u20132019) analyzed data on minor and major LEAs in hospitalized patients recorded in the National School for Public Health, Management, and Health Education database. The absolute numbers and incidences of LEAs were analyzed by diagnosis type, year, age, sex, and amputation level. Results: Of 38,590 vascular disease-related amputations recorded nationwide, 36,162 were in PAD and 2428 in AET patients. The average LEA incidence in the general population was 34.73 (minimum: 31.96 in 2015; maximum: 36.57 in 2019). The average incidence of major amputations, amputations above the knee, hip amputations, amputations below the knee, and minor amputations was 16.21 (15.62 in 2015; 16.84 in 2018), 13.76 (13.33 in 2015; 14.28 in 2018), 0.29 (0.22 in 2017; 0.35 in 2019), 2.15 (2.00 in 2015; 2.28 in 2019), and 18.52 (16.34 in 2015; 20.12 in 2019), respectively. Yearly PAD- and\/or AET-related amputations were significantly higher in men versus women. The overall number of LEAs increased with age, particularly in patients \u2265 70 years. The increase in the total number of amputations was mainly due to a constant rise in minor amputations for both groups, regardless of gender. Conclusions: PAD- and\/or AET-related LEAs in Romania increased from 2015 to 2019, with men having a greater incidence than women. Raising awareness and effective management strategies are needed to prevent LEAs.<\/jats:p>","DOI":"10.3390\/jcm13092549","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T08:18:27Z","timestamp":1714119507000},"page":"2549","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Five-Year Trends of Vascular Disease-Related Amputations in Romania: A Retrospective Database Study"],"prefix":"10.3390","volume":"13","author":[{"given":"Hora\u021biu F.","family":"Coman","sequence":"first","affiliation":[{"name":"Vascular Surgery Clinic, Cluj County Emergency Hospital, 400347 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9319-7428","authenticated-orcid":false,"given":"Bogdan","family":"Stancu","sequence":"additional","affiliation":[{"name":"Second Department of Surgery, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavian A.","family":"Andercou","sequence":"additional","affiliation":[{"name":"Second Department of Surgery, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razvan","family":"Ciocan","sequence":"additional","affiliation":[{"name":"Department of Surgery\u2014Practical Abilities, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia D.","family":"Gherman","sequence":"additional","affiliation":[{"name":"Department of Surgery\u2014Practical Abilities, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0977-8874","authenticated-orcid":false,"given":"Adriana","family":"Rusu","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Nutrition Diseases, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norina A.","family":"Gavan","sequence":"additional","affiliation":[{"name":"W\u00f6rwag Pharma Romania SRL, 400267 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosmina I.","family":"Bondor","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics and Biostatistics, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6722-4808","authenticated-orcid":false,"given":"Alexandru D.","family":"Gavan","sequence":"additional","affiliation":[{"name":"Department of Medical Devices, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6216-9088","authenticated-orcid":false,"given":"Cornelia G.","family":"Bala","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Nutrition Diseases, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4030-1698","authenticated-orcid":false,"given":"Alexandru","family":"Necula","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trif","family":"Ana","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department, \u201cNicolae St\u0103ncioiu\u201d Heart Institute, 400001 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trif","family":"Tatiana","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Department, Regional Institute of Gastroenterology & Hepatology \u201cProf. Dr. Octavian Fodor\u201d, 400394 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L.","family":"Haldenwang","sequence":"additional","affiliation":[{"name":"Department for Cardiothoracic Surgery, University Hospital Bergmannsheil Bochum, Ruhr-University of Bochum, 44789 Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Walter, N., Alt, V., and Rupp, M. 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Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20010557"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/9\/2549\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:33:47Z","timestamp":1760106827000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/9\/2549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,26]]},"references-count":23,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["jcm13092549"],"URL":"https:\/\/doi.org\/10.3390\/jcm13092549","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,26]]}}}