{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T12:19:36Z","timestamp":1780661976624,"version":"3.54.1"},"reference-count":75,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T00:00:00Z","timestamp":1714176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: Although most cases of new-onset type 1 diabetes mellitus (T1DM) are managed without serious events, life-threatening complications do arise in a subset of patients. Our objective was to assess the correlation between elevated SIRI values and adverse events related to the onset of T1DM. (2) Methods: This retrospective study, spanning ten years, included 187 patients with new-onset T1DM divided into three groups based on SIRI tertiles. The primary outcome was the occurrence of acute complications during hospital admission, while the secondary outcome was prolonged Intensive Care Unit (ICU) admission. (3) Results: Patients with high SIRI values were more likely to experience higher disease activity, leading to longer ICU admission times and more frequent complications. Multivariate logistic regression analysis revealed that the SIRI was independently associated with acute complications (p = 0.003) and prolonged ICU length of stay (p = 0.003). Furthermore, receiver operating characteristic analysis demonstrated the SIRI\u2019s superior predictive accuracy compared to venous pH (AUC = 0.837 and AUC = 0.811, respectively) and to the individual component cell lineages of the SIRI. (4) Conclusions: These findings emphasize the potential utility of the SIRI as a prognostic marker in identifying patients at increased risk during T1DM hospital admissions.<\/jats:p>","DOI":"10.3390\/jcm13092582","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T08:49:24Z","timestamp":1714380564000},"page":"2582","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Systemic Inflammatory Response Index (SIRI) as a Predictive Marker for Adverse Outcomes in Children with New-Onset Type 1 Diabetes Mellitus"],"prefix":"10.3390","volume":"13","author":[{"given":"Alexandra-Cristina","family":"Scutca","sequence":"first","affiliation":[{"name":"Department XI Pediatrics, Discipline I Pediatrics, \u2018Victor Babe\u015f\u2019 University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania"},{"name":"Department of Pediatrics I, Children\u2019s Emergency Hospital \u201cLouis Turcanu\u201d, 300011 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iulius","family":"Jug\u0103naru","sequence":"additional","affiliation":[{"name":"Department XI Pediatrics, Discipline I Pediatrics, \u2018Victor Babe\u015f\u2019 University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania"},{"name":"Department of Pediatrics I, Children\u2019s Emergency Hospital \u201cLouis Turcanu\u201d, 300011 Timisoara, Romania"},{"name":"Research Center for Disturbances of Growth and Development in Children BELIVE, \u2018Victor Babe\u015f\u2019 University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6064-2282","authenticated-orcid":false,"given":"Delia-Maria","family":"Nicoar\u0103","sequence":"additional","affiliation":[{"name":"Department XI Pediatrics, Discipline I Pediatrics, \u2018Victor Babe\u015f\u2019 University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7992-4059","authenticated-orcid":false,"given":"Giorgiana-Flavia","family":"Brad","sequence":"additional","affiliation":[{"name":"Department XI Pediatrics, Discipline I Pediatrics, \u2018Victor Babe\u015f\u2019 University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania"},{"name":"Department of Pediatrics I, Children\u2019s Emergency Hospital \u201cLouis Turcanu\u201d, 300011 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meda-Ada","family":"Bugi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics I, Children\u2019s Emergency Hospital \u201cLouis Turcanu\u201d, 300011 Timisoara, Romania"},{"name":"Ph.D. School Department, \u2018Victor Babe\u015f\u2019 University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raluca","family":"Asproniu","sequence":"additional","affiliation":[{"name":"Department XI Pediatrics, Discipline I Pediatrics, \u2018Victor Babe\u015f\u2019 University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania"},{"name":"Department of Pediatrics I, Children\u2019s Emergency Hospital \u201cLouis Turcanu\u201d, 300011 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucian-Ioan","family":"Cristun","sequence":"additional","affiliation":[{"name":"Ph.D. School Department, \u2018Victor Babe\u015f\u2019 University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2313-7643","authenticated-orcid":false,"given":"Otilia","family":"M\u0103rginean","sequence":"additional","affiliation":[{"name":"Department XI Pediatrics, Discipline I Pediatrics, \u2018Victor Babe\u015f\u2019 University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania"},{"name":"Department of Pediatrics I, Children\u2019s Emergency Hospital \u201cLouis Turcanu\u201d, 300011 Timisoara, Romania"},{"name":"Research Center for Disturbances of Growth and Development in Children BELIVE, \u2018Victor Babe\u015f\u2019 University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4973","DOI":"10.2147\/DMSO.S281949","article-title":"Type 1 Diabetes Mellitus in Pediatric Patients and Its Impact on Relationships in the Family Environment","volume":"13","author":"Madrigal","year":"2020","journal-title":"Diabetes Metab. 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