{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:02:03Z","timestamp":1760144523385,"version":"build-2065373602"},"reference-count":16,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Significant pericardial effusion requires percutaneous drainage. Some patients experience recurrent pericardial effusion following index drainage, but its risk factors remain unknown. Such knowledge should further improve the clinical management of individuals presenting with pericardial effusion for risk stratification and the construction of therapeutic and management strategies beforehand. Methods: Patients who underwent percutaneous drainage for pericardial effusion between 2018 and 2023 were retrospectively included and were followed for 2 years or until November 2023. Baseline factors associated with recurrent pericardial effusion that required percutaneous drainage again were investigated to identify the high-risk cohort. Results: A total of 39 patients (83 years on median, 28 males) were included. During the 2-year observation period, 11 patients had the primary outcome. The left ventricular end-diastolic diameter at baseline was independently associated with the primary outcome with an adjusted hazard ratio of 0.88 (95% confidence interval 0.80\u20130.97, p = 0.013) with a cutoff of 42 mm, which significantly stratified the cumulative incidence of the primary outcome (53% versus 10%, p = 0.011). Conclusions: Recurrent pericardial effusion after percutaneous drainage is not a rare phenomenon. A smaller left ventricular endo-diastolic diameter was an independent risk factor for recurrent pericardial effusion. The clinical implications of our findings in daily clinical practice should be validated in future prospective studies. Further studies are warranted to clarify the underlying causality between them.<\/jats:p>","DOI":"10.3390\/jcm13092644","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T08:14:31Z","timestamp":1714464871000},"page":"2644","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Small Left Ventricular Size Is a Risk Factor for Recurrent Pericardial Effusion after Percutaneous Drainage"],"prefix":"10.3390","volume":"13","author":[{"given":"Kousuke","family":"Akao","sequence":"first","affiliation":[{"name":"Second Department of Internal Medicine, University of Toyama, 2630 Sugitani Toyama, Toyama 930-0194, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7294-7637","authenticated-orcid":false,"given":"Teruhiko","family":"Imamura","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, University of Toyama, 2630 Sugitani Toyama, Toyama 930-0194, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Kinugawa","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, University of Toyama, 2630 Sugitani Toyama, Toyama 930-0194, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.jchf.2019.03.021","article-title":"The Role of the Pericardium in Heart Failure: Implications for Pathophysiology and Treatment","volume":"7","author":"Borlaug","year":"2019","journal-title":"JACC Heart Fail."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.pcad.2016.12.009","article-title":"Pericardial Effusions: Causes, Diagnosis, and Management","volume":"59","author":"Vakamudi","year":"2017","journal-title":"Prog. Cardiovasc. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1056\/NEJMra022643","article-title":"Acute cardiac tamponade","volume":"349","author":"Spodick","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"288","DOI":"10.23736\/S0031-0808.20.04197-X","article-title":"Contemporary management of pericardial effusion","volume":"63","author":"Lazaros","year":"2021","journal-title":"Panminerva Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1056\/NEJM199912303412704","article-title":"Long-term follow-up of idiopathic chronic pericardial effusion","volume":"341","author":"Angel","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1001\/jama.1994.03520010071035","article-title":"Treatment of malignant pericardial effusion","volume":"272","author":"Vaitkus","year":"1994","journal-title":"JAMA"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cjca.2023.02.003","article-title":"Chronic Pericardial Effusion: Causes and Management","volume":"39","author":"Lazaros","year":"2023","journal-title":"Can. J. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1001\/jama.1978.03290240033017","article-title":"Pericardial drainage","volume":"240","author":"Spodick","year":"1978","journal-title":"JAMA"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1080\/00325481.2017.1285676","article-title":"Contemporary management of pericardial effusion: Practical aspects for clinical practice","volume":"129","author":"Imazio","year":"2017","journal-title":"Postgrad. Med."},{"key":"ref_10","first-page":"1126","article-title":"2015 ESC Guidelines for the Diagnosis and Management of Pericardial Diseases","volume":"68","author":"Adler","year":"2015","journal-title":"Rev. Esp. Cardiol. (Engl. Ed.)"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0002-9343(00)00459-9","article-title":"Clinical clues to the causes of large pericardial effusions","volume":"109","author":"Merce","year":"2000","journal-title":"Am. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jjcc.2023.03.002","article-title":"In-hospital adverse events and recurrence in hospitalized patients with acute pericarditis","volume":"82","author":"Aikawa","year":"2023","journal-title":"J. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.jacc.2020.08.003","article-title":"Effect of Anti-Inflammatory Drugs on Clinical Outcomes in Patients With Malignant Pericardial Effusion","volume":"76","author":"Kim","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"194","DOI":"10.21470\/1678-9741-2018-0077","article-title":"Treatment of Pericardial Effusion Through Subxiphoid Tube Pericardiostomy and Computerized Tomography- or Echocardiography\u2014Guided Percutaneous Catheter Drainage Methods","volume":"34","author":"Colak","year":"2019","journal-title":"Braz. J. Cardiovasc. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11886-015-0575-y","article-title":"New clinical trials in acute and recurrent pericarditis","volume":"17","author":"Imazio","year":"2015","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/0140-6736(92)91874-8","article-title":"Laparoscopic pericardial fenestration for malignant pericardial effusion","volume":"339","author":"Ready","year":"1992","journal-title":"Lancet"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/9\/2644\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:36:57Z","timestamp":1760107017000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/9\/2644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,30]]},"references-count":16,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["jcm13092644"],"URL":"https:\/\/doi.org\/10.3390\/jcm13092644","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2024,4,30]]}}}