{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:30:33Z","timestamp":1792531833992,"version":"4.5.0"},"reference-count":64,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy Carol Davila"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Burns represent a serious health problem, associated with multiple-organ failure, prolonged hospitalization, septic complications, and increased rate of mortality. The main aim of our study was to evaluate the levels of various circulating molecules in children with severe burns (more than 25% TBSA), in three different moments: 48 h, day 10, and day 21 post-burn. Materials and Methods: This study included 32 children with burns produced by flame, hot liquid, and electric arc and 21 controls. Serum plasminogen activator inhibitor-1 (PAI-1), \u03b1 1-acid glycoprotein (AGP), C-reactive protein (CRP), and platelet factor 4 (PF4) were detected using the Multiplex technique. Several parameters, such as fibrinogen, leucocyte count, thrombocyte count, triiodothyronine, thyroxine, and thyroid-stimulating hormone were also determined for each patient during hospitalization. Results: Significant statistical differences were obtained for CRP, AGP, and PF4 compared to the control group, in different moments of measurements. Negative correlations between CRP, AGP, and PF4 serum levels and burned body surface, and also the hospitalization period, were observed. Discussions: CRP levels increased in the first 10 days after burn trauma and then decreased after day 21. Serum PAI-1 levels were higher immediately after the burn and started decreasing only after day 10 post-burn. AGP had elevated levels 48 h after the burn, then decreased at 7\u201310 days afterwards, and once again increased levels after 21 days. PF4 serum levels increased after day 10 since the burning event. Conclusions: Serum CRP, AGP, PAI-1, and PF4 seem to be promising molecules in monitoring patients with a burn within the first 21 days.<\/jats:p>","DOI":"10.3390\/jcm13102794","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T10:31:16Z","timestamp":1715250676000},"page":"2794","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Serum Plasminogen Activator Inhibitor-1, \u03b1 1-Acid Glycoprotein, C-Reactive Protein, and Platelet Factor 4 Levels\u2014Promising Molecules That Can Complete the \u201cPuzzle\u201d of the Biochemical Milieu in Severe Burns: Preliminary Results of a Cohort Prospective Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6572-9244","authenticated-orcid":false,"given":"Silviu Constantin","family":"Badoiu","sequence":"first","affiliation":[{"name":"Department of Anatomy and Embriology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania"},{"name":"Department of Plastic and Reconstructive Surgery, Life Memorial Hospital, 365 Grivitei Street, 010719 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan Mircea","family":"Enescu","sequence":"additional","affiliation":[{"name":"Department of Plastic Reconstructive Surgery and Burns, Grigore Alexandrescu Clinical Emergency Hospital for Children, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4606-4064","authenticated-orcid":false,"given":"Raluca","family":"Tatar","sequence":"additional","affiliation":[{"name":"Department of Plastic Reconstructive Surgery and Burns, Grigore Alexandrescu Clinical Emergency Hospital for Children, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iulia-Ioana","family":"Stanescu-Spinu","sequence":"additional","affiliation":[{"name":"Discipline of Physiology, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Miricescu","sequence":"additional","affiliation":[{"name":"Discipline of Biochemistry, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Greabu","sequence":"additional","affiliation":[{"name":"Discipline of Biochemistry, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ileana Paula","family":"Ionel","sequence":"additional","affiliation":[{"name":"Discipline of General Nursing, Faculty of Midwifery and Nursing, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7632-5328","authenticated-orcid":false,"given":"Viorel","family":"Jinga","sequence":"additional","affiliation":[{"name":"Department of Urology, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania"},{"name":"Academy of Romanian Scientists, 3 Ilfov, 050085 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0140-6736(16)31469-6","article-title":"The metabolic stress response to burn trauma: Current understanding and therapies","volume":"388","author":"Porter","year":"2016","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"621222","DOI":"10.3389\/fimmu.2020.621222","article-title":"Persistent systemic inflammation in patients with severe burn injury is accompanied by influx of immature neutrophils and shifts in T cell subsets and cytokine profiles","volume":"11","author":"Mulder","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/BCR.0000000000000265","article-title":"Postburn hypermetabolism: Past, present, and future","volume":"37","author":"Jeschke","year":"2016","journal-title":"J. Burn Care Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.21037\/atm-20-288","article-title":"Clinical features and mortality-related factors of extensive burns among young adults: The Kunshan disaster experience","volume":"8","author":"Huang","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.burns.2019.10.017","article-title":"Recognizing the long-term sequelae of burns as a chronic medical condition","volume":"46","author":"Kelter","year":"2020","journal-title":"Burns"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1631\/jzus.2005.B1045","article-title":"Acute phase reaction and acute phase proteins","volume":"6","author":"Gruys","year":"2005","journal-title":"J. Zhejiang Univ.-Sci. B"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1515\/hsz-2021-0209","article-title":"Acute-phase protein synthesis: A key feature of innate immune functions of the liver","volume":"402","author":"Ehlting","year":"2021","journal-title":"Biol. Chem."},{"key":"ref_8","first-page":"137","article-title":"Can we use C-reactive protein levels to predict severe infection or sepsis in severely burned patients?","volume":"3","author":"Jeschke","year":"2013","journal-title":"Int. J. Burn. Trauma"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.burns.2022.05.008","article-title":"C-reactive protein elevation is associated with increased morbidity and mortality in elderly burned patients","volume":"49","author":"Song","year":"2023","journal-title":"Burns"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1172\/JCI200318921","article-title":"C-reactive protein: A critical update","volume":"111","author":"Pepys","year":"2003","journal-title":"J. Clin. Investig."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Dewez, J.E., Nijman, R.G., Fitchett, E.J., Li, E.C., Luu, Q.F., Lynch, R., Emonts, M., de Groot, R., van der Flier, M., and Philipsen, R. (2024). Adoption of C-reactive protein rapid tests for the management of acute childhood infections in hospitals in the Netherlands and England: A comparative health systems analysis. BMC Health Serv. Res., 24.","DOI":"10.1186\/s12913-024-10698-6"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.burns.2006.07.001","article-title":"Inflammatory markers in patients with severe burn injury: What is the best indicator of sepsis?","volume":"33","author":"Lavrentieva","year":"2007","journal-title":"Burns"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jacc.2005.04.051","article-title":"Race and gender differences in C-reactive protein levels","volume":"46","author":"Khera","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/SHK.0000000000001484","article-title":"Burn-induced coagulopathies: A comprehensive review","volume":"54","author":"Ball","year":"2020","journal-title":"Shock"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"22351","DOI":"10.1073\/pnas.2010229117","article-title":"IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome","volume":"117","author":"Kang","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/jth.13283","article-title":"Coagulopathy and its management in patients with severe burns","volume":"14","author":"Glas","year":"2016","journal-title":"J. Thromb. Haemost."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1097\/TA.0000000000002040","article-title":"The procoagulant molecule plasminogen activator inhibitor-1 is associated with injury severity and shock in patients with and without traumatic brain injury","volume":"85","author":"Condron","year":"2018","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/BCR.0b013e31815f59f4","article-title":"Epistatic interactions are critical to gene-association studies: PAI-1 and risk for mortality after burn injury","volume":"29","author":"Barber","year":"2008","journal-title":"J. Burn Care Res."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Wo\u017anica-Niesobska, E., Le\u015bnik, P., Janc, J., Zalewska, M., and \u0141ysenko, L. (2023). The Role of Plasminogen Activator Inhibitor 1 in Predicting Sepsis-Associated Liver Dysfunction: An Observational Study. Int. J. Environ. Res. Public Health, 20.","DOI":"10.3390\/ijerph20064846"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41598-020-79948-x","article-title":"Role of PAI-1 in hepatic steatosis and dyslipidemia","volume":"11","author":"Levine","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e000683","DOI":"10.1136\/bmjgast-2021-000683","article-title":"Plasminogen activator inhibitor is significantly elevated in liver transplant recipients with decompensated NASH cirrhosis","volume":"8","author":"Rivas","year":"2021","journal-title":"BMJ Open Gastroenterol."},{"key":"ref_22","first-page":"2948","article-title":"Novel oral plasminogen activator inhibitor-1 inhibitor TM5275 attenuates hepatic fibrosis under metabolic syndrome via suppression of activated hepatic stellate cells in rats","volume":"22","author":"Noguchi","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_23","first-page":"226","article-title":"Effect of alpha-1-acid glycoprotein binding on pharmacokinetics and pharmacodynamics","volume":"14","author":"Huang","year":"2013","journal-title":"Curr. Drug Metab."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1145962","DOI":"10.3389\/fphar.2023.1145962","article-title":"Determination of \u03b11-Acid Glycoprotein (AGP) concentration by HPLC in patients following local infiltration analgesia for primary total hip arthroplasty and its relation with ropivacaine (total and unbound)","volume":"14","author":"Abbas","year":"2023","journal-title":"Front. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"608466","DOI":"10.3389\/fimmu.2020.608466","article-title":"Glycoproteoform profiles of individual patients\u2019 plasma alpha-1-antichymotrypsin are unique and extensively remodeled following a septic episode","volume":"11","author":"Lin","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"59","DOI":"10.12688\/openreseurope.15810.1","article-title":"Foresight in clinical proteomics: Current status, ethical considerations, and future perspectives","volume":"3","author":"Mundt","year":"2023","journal-title":"Open Res. Eur."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e02879","DOI":"10.1016\/j.heliyon.2019.e02879","article-title":"An overview of albumin and alpha-1-acid glycoprotein main characteristics: Highlighting the roles of amino acids in binding kinetics and molecular interactions","volume":"5","author":"Bteich","year":"2019","journal-title":"Heliyon"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"E384","DOI":"10.1503\/cmaj.160313","article-title":"Association between inflammatory biomarkers and all-cause, cardiovascular and cancer-related mortality","volume":"189","author":"Shipley","year":"2017","journal-title":"CMAJ"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"7953","DOI":"10.1038\/s41598-021-87217-8","article-title":"An acute phase protein \u03b11-acid glycoprotein mitigates AKI and its progression to CKD through its anti-inflammatory action","volume":"11","author":"Watanabe","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Hsiao, S.-Y., Lai, Y.-R., Kung, C.-T., Tsai, N.-W., Su, C.-M., Huang, C.-C., Wang, H.-C., Cheng, B.-C., Su, Y.-J., and Lin, W.-C. (2019). \u03b1-1-acid glycoprotein concentration as an outcome predictor in adult patients with sepsis. BioMed Res. Int., 2019.","DOI":"10.1155\/2019\/3174896"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"G1031","DOI":"10.1152\/ajpgi.1997.273.5.G1031","article-title":"\u03b11-Acid glycoprotein reduces local and remote injuries after intestinal ischemia in the rat","volume":"273","author":"Williams","year":"1997","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.2337\/db11-0825","article-title":"\u03b11-Acid glycoprotein decreases neutrophil migration and increases susceptibility to sepsis in diabetic mice","volume":"61","author":"Spiller","year":"2012","journal-title":"Diabetes"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"505","DOI":"10.2174\/1389203720666190405101138","article-title":"The immune functions of \u03b11 acid glycoprotein","volume":"20","author":"Ceciliani","year":"2019","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"384","DOI":"10.2119\/molmed.2009.00074","article-title":"Platelet factor 4 is highly upregulated in dendritic cells after severe trauma","volume":"15","author":"Maier","year":"2009","journal-title":"Mol. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"27725","DOI":"10.18632\/oncotarget.9486","article-title":"Platelet factor 4 is produced by subsets of myeloid cells in premetastatic lung and inhibits tumor metastasis","volume":"8","author":"Jian","year":"2017","journal-title":"Oncotarget"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/SHK.0b013e3181673eb4","article-title":"Altered gene expression patterns in dendritic cells after severe trauma: Implications for systemic inflammation and organ injury","volume":"30","author":"Maier","year":"2008","journal-title":"Shock"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Cai, Z., Greene, M.I., Zhu, Z., and Zhang, H. (2020). Structural features and PF4 functions that occur in heparin-induced thrombocytopenia (HIT) complicated by COVID-19. Antibodies, 9.","DOI":"10.3390\/antib9040052"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/ijlh.14075","article-title":"Platelet factor 4 triggers thrombo-inflammation by bridging innate and adaptive immunity","volume":"45","author":"Greinacher","year":"2023","journal-title":"Int. J. Lab. Hematol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.burnso.2022.08.001","article-title":"Assessment of histopathological changes in the thyroid gland of fatal burn patients: A cross-sectional study","volume":"6","author":"Chattopadhyay","year":"2022","journal-title":"Burn. Open"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"98","DOI":"10.5811\/cpcem.2016.16.31301","article-title":"Burn-induced myxedema crisis","volume":"1","author":"Batista","year":"2017","journal-title":"Clin. Pract. Cases Emerg. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"610","DOI":"10.31393\/reports-vnmedical-2018-22(4)-05","article-title":"Peculiarities of structural reorganization of the thyroid gland vessels in dynamics after experimental thermal trauma","volume":"22","author":"Korytskyi","year":"2018","journal-title":"Rep. Vinnytsia Natl. Med. Univ."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.burnso.2017.09.003","article-title":"Thyroid storm in a pediatric high voltage electrical burn injury","volume":"2","author":"Sen","year":"2018","journal-title":"Burn. Open"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e776","DOI":"10.1097\/BCR.0000000000000499","article-title":"Thyroid crisis in a patient with burn injury","volume":"38","author":"Sofianos","year":"2017","journal-title":"J. Burn Care Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1001\/archsurg.138.2.220","article-title":"Diagnostic implications of C-reactive protein","volume":"138","author":"Zimmerman","year":"2003","journal-title":"Arch. Surg."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/00005373-197402000-00007","article-title":"SERUM PROTEIN PROFILES IN THERMAL BURNS II. Protease Inhibitors, Complement Factors, and C-Reactive Protein","volume":"14","author":"Daniles","year":"1974","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_46","first-page":"20","article-title":"Effects of empirical antibiotic administration on the level of C-Reactive protein and inflammatory markers in severe burn patients","volume":"33","author":"Putra","year":"2020","journal-title":"Ann. Burn. Fire Disasters"},{"key":"ref_47","first-page":"117","article-title":"Recent advances in biomarkers in severe burns","volume":"45","author":"Roca","year":"2016","journal-title":"Shock Inj. Inflamm. Sepsis Lab. Clin. Approaches"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Jeschke, M.G., Gauglitz, G.G., Kulp, G.A., Finnerty, C.C., Williams, F.N., Kraft, R., Suman, O.E., Mlcak, R.P., and Herndon, D.N. (2011). Long-term persistance of the pathophysiologic response to severe burn injury. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0021245"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0305-4179(01)00011-0","article-title":"Elevation of plasma free PAI-1 levels as an integrated endothelial response to severe burns","volume":"27","author":"Aoki","year":"2001","journal-title":"Burns"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/BCR.0000000000000468","article-title":"Randomized comparison of packed red blood cell-to-fresh frozen plasma transfusion ratio of 4: 1 vs 1: 1 during acute massive burn excision","volume":"38","author":"Galganski","year":"2017","journal-title":"J. Burn Care Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"P365","DOI":"10.1186\/cc5525","article-title":"Early coagulation alterations in intensive care unit burn patients","volume":"11","author":"Lavrendieva","year":"2007","journal-title":"Crit. Care"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Sillen, M., Miyata, T., Vaughan, D.E., Strelkov, S.V., and Declerck, P.J. (2021). Structural insight into the two-step mechanism of PAI-1 inhibition by small molecule TM5484. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031482"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.burnso.2021.08.075","article-title":"Blood coagulation alterations over the first 10 days after severe burn injury","volume":"6","author":"Barbier","year":"2022","journal-title":"Burn. Open"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/00005373-199202000-00022","article-title":"The effects of burn injury on the acute phase response","volume":"32","author":"Xia","year":"1992","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_55","first-page":"105","article-title":"The prognostic value of nutritional and inflammatory indices in patients with burns","volume":"13","author":"Gottschlich","year":"1992","journal-title":"J. Burn Care Rehabil."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0303-7207(01)00650-5","article-title":"The influence of alpha1-acid glycoprotein (orosomucoid) and its glycoforms on the function of human thyrocytes and CHO cells transfected with the human TSH receptor","volume":"188","author":"Rasmussen","year":"2002","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"351864","DOI":"10.1155\/2012\/351864","article-title":"TSH and thyrotropic agonists: Key actors in thyroid homeostasis","volume":"2012","author":"Dietrich","year":"2012","journal-title":"J. Thyroid Res."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Vale, N., Pereira, M., and Mendes, R.A. (2023). Systemic Inflammatory Disorders, Immunosuppressive Treatment and Increase Risk of Head and Neck Cancers\u2014A Narrative Review of Potential Physiopathological and Biological Mechanisms. Cells, 12.","DOI":"10.3390\/cells12172192"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.thromres.2009.11.023","article-title":"Role of the platelet chemokine platelet factor 4 (PF4) in hemostasis and thrombosis","volume":"125","author":"Kowalska","year":"2010","journal-title":"Thromb. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1098665","DOI":"10.3389\/fimmu.2023.1098665","article-title":"New perspectives on the induction and acceleration of immune-associated thrombosis by PF4 and VWF","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1160\/TH14-11-0947","article-title":"Platelets, inflammation and anti-inflammatory effects of antiplatelet drugs in ACS and CAD","volume":"114","author":"Chatterjee","year":"2015","journal-title":"Thromb. Haemost."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/s41586-023-06436-3","article-title":"Platelet factors attenuate inflammation and rescue cognition in ageing","volume":"620","author":"Horowitz","year":"2023","journal-title":"Nature"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"981984","DOI":"10.1155\/2013\/981984","article-title":"Differential expression of host biomarkers in saliva and serum samples from individuals with suspected pulmonary tuberculosis","volume":"2013","author":"Phalane","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/01.shk.0000228170.94468.e1","article-title":"Children under 4 years are at greater risk of mortality following acute burn injury: Evidence from a national sample of 12,902 pediatric admissions","volume":"26","author":"Thombs","year":"2006","journal-title":"Shock"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/10\/2794\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:42:44Z","timestamp":1760107364000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/10\/2794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,9]]},"references-count":64,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["jcm13102794"],"URL":"https:\/\/doi.org\/10.3390\/jcm13102794","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,9]]}}}