{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T17:07:11Z","timestamp":1774544831676,"version":"3.50.1"},"reference-count":16,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Schweizerische Muskelgesellschaft"},{"name":"Association Suisse Romande Intervenant contre les Maladies neuro-Musculaires"},{"name":"Associazione Malattie Genetiche Rare Svizzera italiana"},{"name":"SMA Schweiz"},{"name":"Duchenne Schweiz"},{"name":"Schweizerische Stiftung f\u00fcr die Erforschung der Muskelkrankheiten"},{"name":"PTC Therapeutics International"},{"name":"Sarepta International"},{"name":"Pfizer Switzerland"},{"name":"Roche Pharma Schweiz"},{"name":"Novartis Gene Therapies"},{"name":"Biogen Switzerland AG"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background and Objectives: Chronic pain is a common symptom in various types of neuromuscular disorders. However, for patients with spinal muscular atrophy (SMA), the literature regarding chronic pain is scarce. Thus, this study assessed the prevalence of chronic pain in children, adolescents, and adults with SMA and investigated the influence of clinical characteristics on chronic pain. Materials and Methods: This study used data from 141 patients, which were collected by the Swiss Registry for Neuromuscular Disorders. Extracted data included information on pain (present yes\/no, pain location, and pain medication) and clinical characteristics, such as SMA type, motor function, wheelchair use, scoliosis, and contractures. Results: The analyses revealed that the highest prevalence of chronic pain was observed in adolescents with 62%, followed by adults with 48%, children (6\u201312 years) with 39%, and children &lt; 6 years with 10%. The legs, back, and hips were most frequently reported as pain locations. Sex (females), age (adolescents), and the presence of contractures and scoliosis (with surgery) were factors that were associated with chronic pain. Conclusions: These findings contribute to a better understanding of pain in SMA, shedding light on its prevalence and characteristics in different age groups, which underscores the importance of assessing and managing pain in patients with SMA.<\/jats:p>","DOI":"10.3390\/jcm13102798","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T10:31:16Z","timestamp":1715250676000},"page":"2798","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Chronic Pain in Patients with Spinal Muscular Atrophy in Switzerland: A Query to the Spinal Muscular Atrophy Registry"],"prefix":"10.3390","volume":"13","author":[{"given":"Leonie","family":"Steiner","sequence":"first","affiliation":[{"name":"Division of Neuropediatrics, Development and Rehabilitation, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, 3012 Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Tscherter","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine, University of Bern, 3010 Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Henzi","sequence":"additional","affiliation":[{"name":"Division of Neuropediatrics, Development and Rehabilitation, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, 3012 Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8063-7882","authenticated-orcid":false,"given":"Mattia","family":"Branca","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, University of Bern, 3010 Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Carda","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Lausanne University Hospital (CHUV), 1005 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Enzmann","sequence":"additional","affiliation":[{"name":"Division of Neuropediatrics and Developmental Medicine, University Children\u2019s Hospital Basel (UKBB), University of Basel, 4001 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00ebl","family":"Fluss","sequence":"additional","affiliation":[{"name":"Neuropediatric Unit, Children\u2019s Hospital, University Hospital of Geneva, 1205 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Jacquier","sequence":"additional","affiliation":[{"name":"Pediatric Neurology and Neurorehabilitation Unit, Lausanne University Hospital, 1005 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1874-8872","authenticated-orcid":false,"given":"Christoph","family":"Neuwirth","sequence":"additional","affiliation":[{"name":"Neuromuscular Diseases Unit\/ALS Clinic, Cantonal Hospital St. Gallen, 9000 St. Gallen, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8662-9656","authenticated-orcid":false,"given":"Paolo","family":"Ripellino","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurocenter of Southern Switzerland EOC, 6900 Lugano, Switzerland"},{"name":"Faculty of Biomedical Sciences, Universit\u00e0 della Svizzera Italiana, 6900 Lugano, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3925-5142","authenticated-orcid":false,"given":"Olivier","family":"Scheidegger","sequence":"additional","affiliation":[{"name":"Centre for Neuromuscular Diseases, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Schlaeger","sequence":"additional","affiliation":[{"name":"Neurology Clinic and Policlinic, Departments of Head, Spine and Neuromedicine, Clinical Research and Biomedical Engineering, University Hospital Basel, University of Basel, 4001 Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Schreiner","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Zurich, 8032 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0906-8816","authenticated-orcid":false,"given":"Georg M.","family":"Stettner","sequence":"additional","affiliation":[{"name":"Neuromuscular Center Zurich, Department of Pediatric Neurology, University Children\u2019s Hospital Zurich, University of Zurich, 8032 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2733-5911","authenticated-orcid":false,"given":"Andrea","family":"Klein","sequence":"additional","affiliation":[{"name":"Division of Neuropediatrics, Development and Rehabilitation, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, 3012 Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0960-8966(06)80015-5","article-title":"International SMA consortium meeting. 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