{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T08:09:13Z","timestamp":1774598953727,"version":"3.50.1"},"reference-count":45,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T00:00:00Z","timestamp":1715385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Karl Landsteiner University of Health Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Lipedema is a subcutaneous adipose tissue disorder characterized by increased pathological adipocytes mainly in the extremities. Vitamin D is stored in adipocytes, and serum levels inversely correlate with BMI. As adipocytes are removed during liposuction, lipedema patients might be prone to further substantial vitamin D loss while their levels are already decreased. Therefore, we examined the effect of liposuction on perioperative serum 25-hydroxyvitamin D levels. Methods: In patients undergoing lipedema liposuction, blood samples were obtained pre- and postoperatively. Statistical analyses were performed to correlate the volume of lipoaspirate, patients\u2019 BMI and number of sessions to vitamin D levels. Results: Overall, 213 patients were analyzed. Mean liposuction volume was 6615.33 \u00b1 3884.25 mL, mean BMI was 32.18 \u00b1 7.26 kg\/m2. mean preoperative vitamin D levels were 30.1 \u00b1 14.45 ng\/mL (borderline deficient according to the endocrine society) and mean postoperative vitamin D levels were 21.91 \u00b1 9.18 ng\/mL (deficient). A significant decrease in serum vitamin D was seen in our patients (p &lt; 0.001) of mean 7.83 ng\/mL. The amount of vitamin D loss was not associated with BMI or aspiration volume in our patients (p &gt; 0.05). Interestingly, vitamin D dynamics showed a steady drop regardless of volume aspirated or preoperative levels. Conclusions: Many lipedema patients have low vitamin D levels preoperatively. Liposuction significantly reduced these levels additionally, regardless of aspirated volume or BMI. However, vitamin D loss was constant and predictable; thus, patients at risk are easily identified. Overall, lipedema patients undergoing liposuction are prone to vitamin D deficiency, and the long-term effects in this population are currently unknown.<\/jats:p>","DOI":"10.3390\/jcm13102846","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T09:28:25Z","timestamp":1715592505000},"page":"2846","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["High-Volume Liposuction in Lipedema Patients: Effects on Serum Vitamin D"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8612-4693","authenticated-orcid":false,"given":"Tonatiuh","family":"Flores","sequence":"first","affiliation":[{"name":"Karl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems, Austria"},{"name":"Clinical Department of Plastic, Aesthetic and Reconstructive Surgery, University Clinic of St. Poelten, 3100 St. Poelten, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celina","family":"Kerschbaumer","sequence":"additional","affiliation":[{"name":"Karl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5966-0781","authenticated-orcid":false,"given":"Florian J.","family":"Jaklin","sequence":"additional","affiliation":[{"name":"Clinical Laboratory for Bionic Extremity Reconstruction, University Clinic for Plastic, Reconstructive and Aesthetic Surgery, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Glisic","sequence":"additional","affiliation":[{"name":"Karl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems, Austria"},{"name":"Clinical Department of Plastic, Aesthetic and Reconstructive Surgery, University Clinic of St. Poelten, 3100 St. Poelten, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Sabitzer","sequence":"additional","affiliation":[{"name":"Karl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems, Austria"},{"name":"Clinical Department of Plastic, Aesthetic and Reconstructive Surgery, University Clinic of St. Poelten, 3100 St. Poelten, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Nedomansky","sequence":"additional","affiliation":[{"name":"Karl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems, Austria"},{"name":"Clinical Department of Plastic, Aesthetic and Reconstructive Surgery, University Clinic of St. Poelten, 3100 St. Poelten, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Wolf","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Weber","sequence":"additional","affiliation":[{"name":"Karl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3910-9727","authenticated-orcid":false,"given":"Konstantin D.","family":"Bergmeister","sequence":"additional","affiliation":[{"name":"Karl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems, Austria"},{"name":"Clinical Department of Plastic, Aesthetic and Reconstructive Surgery, University Clinic of St. Poelten, 3100 St. Poelten, Austria"},{"name":"Clinical Laboratory for Bionic Extremity Reconstruction, University Clinic for Plastic, Reconstructive and Aesthetic Surgery, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus F.","family":"Schr\u00f6gendorfer","sequence":"additional","affiliation":[{"name":"Karl Landsteiner University of Health Sciences, Dr. Karl-Dorrek-Stra\u00dfe 30, 3500 Krems, Austria"},{"name":"Clinical Department of Plastic, Aesthetic and Reconstructive Surgery, University Clinic of St. Poelten, 3100 St. Poelten, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1177\/1534734614554284","article-title":"Lipedema: A Review of the Literature","volume":"14","author":"Okhovat","year":"2015","journal-title":"Int. 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