{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:43:56Z","timestamp":1787921036780,"version":"build-2784847793"},"reference-count":43,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Health","award":["1R44AR079293"],"award-info":[{"award-number":["1R44AR079293"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The controlled dynamization of fractures can promote natural fracture healing by callus formation, while overly rigid fixation can suppress healing. The advent of locked plating technology enabled new strategies for the controlled dynamization of fractures, such as far cortical locking (FCL) screws or active plates with elastically suspended screw holes. However, these strategies did not allow for the use of non-locking screws, which are typically used to reduce bone fragments to the plate. This study documents the first in vivo study on the healing of ovine tibia osteotomies stabilized with an advanced active plate (AAP). This AAP allowed plate application using any combination of locking and non-locking screws to support a wide range of plate application techniques. At week 9 post-surgery, tibiae were harvested and tested in torsion to failure to assess the healing strength. The five tibiae stabilized with an AAP regained 54% of their native strength and failed by spiral fracture through a screw hole, which did not involve the healed osteotomy. In comparison, tibiae stabilized with a standard locking plate recovered 17% of their strength and sustained failure through the osteotomy. These results further support the stimulatory effect of controlled motion on fracture healing. As such, the controlled dynamization of locked plating constructs may hold the potential to reduce healing complications and may shorten the time to return to function. Integrating controlled dynamization into fracture plates that support a standard fixation technique may facilitate the clinical adoption of dynamic plating.<\/jats:p>","DOI":"10.3390\/jcm13102905","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T10:26:36Z","timestamp":1715682396000},"page":"2905","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Advances in Dynamization of Plate Fixation to Promote Natural Bone Healing"],"prefix":"10.3390","volume":"13","author":[{"given":"Michael","family":"Bottlang","sequence":"first","affiliation":[{"name":"Biomechanics Laboratory, Legacy Research Institute, Portland, OR 97232, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil S.","family":"Shetty","sequence":"additional","affiliation":[{"name":"Biomechanics Laboratory, Legacy Research Institute, Portland, OR 97232, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor","family":"Blankenau","sequence":"additional","affiliation":[{"name":"Biomechanics Laboratory, Legacy Research Institute, Portland, OR 97232, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Wilk","sequence":"additional","affiliation":[{"name":"Department of Comparative Medicine, Legacy Research Institute, Portland, OR 97232, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Tsai","sequence":"additional","affiliation":[{"name":"Biomechanics Laboratory, Legacy Research Institute, Portland, OR 97232, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Fitzpatrick","sequence":"additional","affiliation":[{"name":"Slocum Center for Orthopedics and Sports Medicine, Eugene, OR 97401, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence J.","family":"Marsh","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Madey","sequence":"additional","affiliation":[{"name":"Biomechanics Laboratory, Legacy Research Institute, Portland, OR 97232, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,14]]},"reference":[{"key":"ref_1","unstructured":"Longfellow, E.E. 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