{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:23:57Z","timestamp":1791221037379,"version":"4.1.0"},"reference-count":54,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: new-onset atrial fibrillation remains a common complication in critical care settings, often necessitating treatment when the correction of triggers is insufficient to restore hemodynamics. The treatment strategy includes electric cardioversion in cases of hemodynamic instability and either rhythm control or rate control in the absence of instability. Landiolol, an ultrashort beta-blocker, effectively controls heart rate with the potential to regulate rhythm. Objectives This review aims to compare the efficacy of landiolol in controlling heart rate and converting to sinus rhythm in the critical care setting. Methods: We conducted a comprehensive review of the published literature from 2000 to 2022 describing the use of landiolol to treat atrial fibrillation in critical care settings, excluding both cardiac surgery and medical cardiac care settings. The primary outcome assessed was sinus conversion following landiolol treatment. Results: Our analysis identified 17 publications detailing the use of landiolol for the treatment of 324 critical care patients. While the quality of the data was generally low, primarily comprising non-comparative studies, landiolol consistently demonstrated similar efficacy in controlling heart rate and facilitating conversion to sinus rhythm in both non-surgical (75.7%) and surgical (70.1%) settings. The incidence of hypotension associated with landiolol use was 13%. Conclusions: The use of landiolol in critical care patients with new-onset atrial fibrillation exhibited comparable efficacy and tolerance in both non-surgical and surgical settings. Despite these promising results, further validation through randomized controlled trials is necessary.<\/jats:p>","DOI":"10.3390\/jcm13102951","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T04:26:29Z","timestamp":1715919989000},"page":"2951","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Landiolol for Treatment of New-Onset Atrial Fibrillation in Critical Care: A Systematic Review"],"prefix":"10.3390","volume":"13","author":[{"given":"Bruno","family":"Levy","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Intensive et R\u00e9animation Brabois, CHRU Nancy, P\u00f4le Cardio-M\u00e9dico-Chirurgical, Universit\u00e9 de Lorraine, 54511 Vand\u0153uvre-l\u00e8s-Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Slama","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Amiens Picardie University Hospital, 80054 Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Lakbar","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Unit, H\u00f4pital Nord, Assistance Publique H\u00f4pitaux de Marseille, Aix Marseille University, 13385 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Maizel","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Amiens Picardie University Hospital, 80054 Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, H\u00f4pital Bic\u00eatre, Assistance Publique H\u00f4pitaux de Paris, 78 rue du G\u00e9n\u00e9ral Leclerc, 94270 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3097-758X","authenticated-orcid":false,"given":"Marc","family":"Leone","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Unit, H\u00f4pital Nord, Assistance Publique H\u00f4pitaux de Marseille, Aix Marseille University, 13385 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3779-6703","authenticated-orcid":false,"given":"Motoi","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Asahikawa Medical University, Asahikawa 078-8510, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1164\/rccm.201603-0618OC","article-title":"Incidence, Predictors, and Outcomes of New-Onset Atrial Fibrillation in Critically Ill Patients with Sepsis. 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Suppl."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"100571","DOI":"10.1016\/j.eclinm.2020.100571","article-title":"Impact of patient characteristics on the efficacy and safety of landiolol in patients with sepsis- related tachyarrhythmia: Subanalysis of the J-Land 3S randomised controlled study","volume":"28","author":"Matsuda","year":"2020","journal-title":"EClinicalMedicine"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1001\/jama.2023.20134","article-title":"STRESS-L Collaborators. Landiolol and Organ Failure in Patients with Septic Shock: The STRESS-L Randomized Clinical Trial","volume":"330","author":"Whitehouse","year":"2023","journal-title":"JAMA"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/10\/2951\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:43:42Z","timestamp":1760107422000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/10\/2951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,17]]},"references-count":54,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["jcm13102951"],"URL":"https:\/\/doi.org\/10.3390\/jcm13102951","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,17]]}}}