{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:22:24Z","timestamp":1772842944926,"version":"3.50.1"},"reference-count":37,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T00:00:00Z","timestamp":1716076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: The objective was to examine the association between poor ovarian response to gonadotropin stimulation for in vitro fertilization (IVF) and adverse perinatal outcomes in singleton gestations in young patients. Methods: This was a retrospective cohort study including women aged 17\u201339 who underwent fresh embryo transfer and delivered a singleton neonate at a single center (pre-implantation genetic testing excluded) (2007\u20132022). Patients were classified as one of the following categories: poor responders\u2014daily follicle-stimulating hormone (FSH) \u2265 150 IU yielding \u2264 3 retrieved oocytes; normal responders\u20144\u201315 oocytes; and high responders with \u226516 oocytes. The primary outcome was a composite of pre-eclampsia (mild or severe), small-for-gestational-age, gestational diabetes mellitus, and preterm birth (&lt;37 weeks). We compared maternal and neonatal outcomes between the three groups. Multivariable logistic regression was used to control for confounders. Results: Overall, 507 women met the inclusion criteria. Of them, there were 44 (8.68%) poor responders, 342 (67.46%) normal responders, and 121 (23.87%) high responders. Poor responders, compared to normal and high responders, were characterized by a higher maternal age (34.64 \u00b1 4.01 vs. 31.4 \u00b1 5.04 vs. 30.01 \u00b1 4.93, p &lt; 0.001, respectively) and total FSH dosage (3028.41 \u00b1 1792.05 IU vs. 2375.11 \u00b1 1394.05 IU vs. 1869.31 \u00b1 1089.63 IU, p &lt; 0.001). The perinatal outcomes examined, including cesarean delivery (CD) rate and the composite outcome, were comparable between groups. Using multivariable logistic regression and adjusting for ovarian response group, maternal age, nulliparity, and estradiol level and endometrial thickness before ovulation triggering, poor response was not associated with CD rate or the composite outcome, with maternal age associated with CD (p = 0.005), and nulliparity with the composite outcome (p = 0.007). Similar results were obtained when comparing poor responders to each other group separately or to all other responders. Conclusions: Poor ovarian response is not associated with increased adverse maternal or neonatal outcomes.<\/jats:p>","DOI":"10.3390\/jcm13102985","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T06:31:58Z","timestamp":1716186718000},"page":"2985","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Poor Response to Gonadotropin Stimulation and Perinatal Outcomes in Fresh In Vitro Fertilization Embryo Transfer Cycles\u2014A Retrospective Cohort Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7387-409X","authenticated-orcid":false,"given":"Alyssa","family":"Hochberg","sequence":"first","affiliation":[{"name":"IVF and Infertility Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva 4941492, Israel"},{"name":"The Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avital","family":"Wertheimer","sequence":"additional","affiliation":[{"name":"IVF and Infertility Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva 4941492, Israel"},{"name":"The Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Zlatkin","sequence":"additional","affiliation":[{"name":"IVF and Infertility Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva 4941492, Israel"},{"name":"The Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onit","family":"Sapir","sequence":"additional","affiliation":[{"name":"IVF and Infertility Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva 4941492, Israel"},{"name":"The Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5859-9528","authenticated-orcid":false,"given":"Eyal","family":"Krispin","sequence":"additional","affiliation":[{"name":"IVF and Infertility Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva 4941492, Israel"},{"name":"The Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzippy","family":"Schohat","sequence":"additional","affiliation":[{"name":"IVF and Infertility Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva 4941492, Israel"},{"name":"The Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eran","family":"Altman","sequence":"additional","affiliation":[{"name":"IVF and Infertility Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva 4941492, Israel"},{"name":"The Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avi","family":"Ben-Haroush","sequence":"additional","affiliation":[{"name":"IVF and Infertility Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva 4941492, Israel"},{"name":"The Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2759-5588","authenticated-orcid":false,"given":"Yoel","family":"Shufaro","sequence":"additional","affiliation":[{"name":"IVF and Infertility Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva 4941492, Israel"},{"name":"The Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ejogrb.2009.05.035","article-title":"Preterm birth and low birth weight among in vitro fertilization singletons: A systematic review and meta-analyses","volume":"146","author":"McDonald","year":"2009","journal-title":"Eur. 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