{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:32:26Z","timestamp":1776270746864,"version":"3.50.1"},"reference-count":22,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Asan Institute for Life Sciences, Asan Medical Center","award":["2019-0589"],"award-info":[{"award-number":["2019-0589"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: Simultaneous removal and cochlear implantation (CI) have been reported in intralabyrinthine and intracochlear schwannoma. A wide range of postoperative hearing outcomes have been reported after CI in these cases. This study evaluated the outcomes of performing a simultaneous resection of Schwannoma in cochlea and cochlear implantation (CI), aiming to assess the effectiveness of this combined surgical approach for hearing rehabilitation with CI. Methods: This retrospective case series was conducted at a tertiary care center. The study included four consecutive patients with profound sensorineural hearing loss due to a mass inside the cochlea. These patients underwent simultaneous single-sided CI and tumor resection performed by the same surgeon. Preoperative and postoperative audiological assessments were conducted to evaluate the patients\u2019 hearing outcomes before and after the surgical intervention. Results: Simultaneous CI with tumor resection was successful in all cases. Two of the four patients had a unilateral tumor, while the other two had a bilateral tumor with the involvement of the internal auditory canal and cerebellopontine angle (neurofibromatosis type 2 (NF2)). In two cases of unilateral tumor, aided free-field pure tone average (PTA) was 26 dB, and 46 dB hearing level (HL), and word recognition score (WRS) at 65 dB was 40% and 68%, respectively, 3 months after surgery. In two cases of tumor with NF2, aided free-field PTA was 36 dB and 60 dB HL, and both cases showed 0% WRS at 65 dB 3 months after surgery. Conclusions: Simultaneous schwannoma excision and CI in patients with Schwannoma inside cochlea are surgically practical and safe. Postoperatively, there was a notable improvement in hearing in cases of sporadic schwannoma, regardless of the type of CI used. However, there was 0% WRS in the two NF2 patients with a mass in the internal auditory canal.<\/jats:p>","DOI":"10.3390\/jcm13113042","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T10:00:11Z","timestamp":1716372011000},"page":"3042","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Audiological Outcome of the Simultaneous Tumor Resection and Cochlear Implantation in Two Cases of Sporadic and Two Cases of Neurofibromatosis Type 2-Associated Intracochlear Schwannoma"],"prefix":"10.3390","volume":"13","author":[{"given":"Abdullah A.","family":"AlMutawah","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"},{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Jahra Hospital, Ministry of Health, Jahra 00043, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3554-1566","authenticated-orcid":false,"given":"Taegyeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0765-9134","authenticated-orcid":false,"given":"Jong Woo","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1055\/s-0040-1715606","article-title":"Cochlear Implantation in Vestibular Schwannoma: A Systematic Literature Review","volume":"82","author":"Tadokoro","year":"2021","journal-title":"J. Neurol. Surg. Part B Skull Base"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1007\/s12105-020-01155-x","article-title":"Vestibular Schwannoma: What We Know and Where We are Heading","volume":"14","author":"Gupta","year":"2020","journal-title":"Head Neck Pathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/neuonc\/noz153","article-title":"EANO guideline on the diagnosis and treatment of vestibular schwannoma","volume":"22","author":"Goldbrunner","year":"2020","journal-title":"Neuro-oncology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1177\/00034894221092844","article-title":"Resection of Intracochlear Schwannomas with Immediate Cochlear Implantation","volume":"132","author":"Patel","year":"2023","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s11060-015-1827-9","article-title":"Incidence of vestibular schwannomas in the United States","volume":"124","author":"Kshettry","year":"2015","journal-title":"J. Neurooncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1002\/lary.23928","article-title":"Primary inner ear schwannomas: A case series and systematic review of the literature","volume":"123","author":"Carlson","year":"2013","journal-title":"Laryngoscope"},{"key":"ref_7","first-page":"136","article-title":"Diagnosis and management of intralabyrinthine schwannoma: Case series and review of the literature","volume":"91","author":"Paolucci","year":"2020","journal-title":"Acta Biomed."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3174\/ajnr.A2712","article-title":"Intralabyrinthine schwannomas: Imaging diagnosis and classification","volume":"33","author":"Salzman","year":"2012","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1097\/MAO.0000000000001016","article-title":"Cochlear Implantation in Patients with Intracochlear and Intralabyrinthine Schwannomas","volume":"37","author":"Carlson","year":"2016","journal-title":"Otol. Neurotol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/MAO.0000000000001696","article-title":"Cochlear Implantation after Partial or Subtotal Cochleoectomy for Intracochlear Schwannoma Removal\u2014A Technical Report","volume":"39","author":"Plontke","year":"2018","journal-title":"Otol. Neurotol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3390\/audiolres13020017","article-title":"Cochlear implantation in intralabyrinthine schwannoma: Case series and systematic review of the literature","volume":"13","author":"Franchella","year":"2023","journal-title":"Audiol. Res."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Haussler, S.M., Szczepek, A.J., Grabel, S., and Olze, H. (2021). Challenges of Cochlear Implantation in Intralabyrinthine Schwannoma Patients: Surgical Procedures and Auditory Outcome. J. Clin. Med., 10.","DOI":"10.3390\/jcm10173899"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/s00405-015-3548-2","article-title":"Meta-analysis on the clinical outcomes in patients with intralabyrinthine schwannomas: Conservative management vs. microsurgery","volume":"273","author":"Gosselin","year":"2016","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1097\/MAO.0000000000002784","article-title":"Cochlear Implant Outcomes following Vestibular Schwannoma Resection: Systematic Review","volume":"41","author":"Wick","year":"2020","journal-title":"Otol. Neurotol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1177\/000348949910800707","article-title":"Intracochlear schwannoma and cochlear implantation","volume":"108","author":"Kronenberg","year":"1999","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1097\/MAO.0000000000002614","article-title":"How much cochlea do you need for cochlear implantation?","volume":"41","author":"Plontke","year":"2020","journal-title":"Otol. Neurotol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/ohn.300","article-title":"Surgical Outcomes of Simultaneous Cochlear Implantation and Intracochlear Schwannoma Removal","volume":"169","author":"Ha","year":"2023","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1097\/00129492-200606000-00013","article-title":"Cochlear implantation in patients with neurofibromatosis type 2 and bilateral vestibular schwannoma","volume":"27","author":"Lustig","year":"2006","journal-title":"Otol. Neurotol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.wneu.2020.07.031","article-title":"Gamma Knife Radiosurgery for Transmodiolar Schwannoma","volume":"143","author":"Diniz","year":"2020","journal-title":"World Neurosurg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s43856-021-00036-w","article-title":"A case series shows independent vestibular labyrinthine function after major surgical trauma to the human cochlea","volume":"1","author":"Plontke","year":"2021","journal-title":"Commun. Med."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Sudhoff, H., Scholtz, L.U., Gehl, H.B., and Todt, I. (2021). Quality Control after Intracochlear Intralabyrinthine Schwannoma Resection and Cochlear Implantation. Brain Sci., 11.","DOI":"10.3389\/fneur.2020.00759"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1148\/rg.2018170135","article-title":"MR imaging and cochlear implants with retained internal magnets: Reducing artifacts near highly inhomogeneous magnetic fields","volume":"38","author":"Edmonson","year":"2018","journal-title":"Radiographics"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/11\/3042\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:46:38Z","timestamp":1760107598000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/11\/3042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,22]]},"references-count":22,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["jcm13113042"],"URL":"https:\/\/doi.org\/10.3390\/jcm13113042","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,22]]}}}