{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:49:32Z","timestamp":1770986972968,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fund Industry, Science and Education Support Fund (Russia)","award":["1\/2022"],"award-info":[{"award-number":["1\/2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>State-of-the-art therapy improves the five-year survival rate of patients under the age of 20 with cranial and craniospinal tumors by up to 74%. The urgency of dealing effectively with late treatment-associated cardiovascular complications is rising. Objective: We aimed to assess echocardiographic parameters and exercise performance in subjects with a history of complex treatment for cranial and craniospinal tumors in childhood. Methods: the study of 48 subjects who underwent cranial and craniospinal irradiation for CNS tumors in childhood and 20 healthy age- and sex-matched volunteers was conducted. The examination included hormone studies, cardiopulmonary exercise testing, and, in the main group, echocardiography (ECHO). Results: In five (10.4%) patients, ECHO changes were detected after complex anti-cancer treatment: thickening and calcification of the aortic valve leaflets (2%), and reduction in the systolic LV and RV function (8% and 6%, respectively). Irradiation of various areas was a significant predictor for reduced exercise tolerance, hyperventilation at rest and upon exertion, and an increased ventilatory equivalent for carbon dioxide. Low exercise tolerance was associated with a younger age at the time of treatment initiation. Significant differences were noted between the control group and the childhood cancer survivors with endocrine disorders. Conclusions: The obtained data confirm the importance of regular cardiovascular and endocrine monitoring of this group of cancer survivors.<\/jats:p>","DOI":"10.3390\/jcm13113045","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T11:03:47Z","timestamp":1716375827000},"page":"3045","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cardiac Dysfunction and Exercise Tolerance in Patients after Complex Treatment for Cranial and Craniospinal Tumors in Childhood"],"prefix":"10.3390","volume":"13","author":[{"given":"Alena","family":"Novikova","sequence":"first","affiliation":[{"name":"Department of Cardiology, Functional and Ultrasound Diagnostics of N.V. Sklifosovsky Institute for Clinical Medicine, I.M Sechenov First Moscow State Medical University (Sechenov University), Moscow 119435, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4463-2897","authenticated-orcid":false,"given":"Maria","family":"Poltavskaya","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Functional and Ultrasound Diagnostics of N.V. Sklifosovsky Institute for Clinical Medicine, I.M Sechenov First Moscow State Medical University (Sechenov University), Moscow 119435, Russia"},{"name":"Federal State Institution \u201cScientific Research Institute for System Analysis of the Russian Academy of Sciences\u201d, Moscow 117218, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Pavlova","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Functional and Ultrasound Diagnostics of N.V. Sklifosovsky Institute for Clinical Medicine, I.M Sechenov First Moscow State Medical University (Sechenov University), Moscow 119435, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1485-6072","authenticated-orcid":false,"given":"Petr","family":"Chomakhidze","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Functional and Ultrasound Diagnostics of N.V. Sklifosovsky Institute for Clinical Medicine, I.M Sechenov First Moscow State Medical University (Sechenov University), Moscow 119435, Russia"},{"name":"Federal State Institution \u201cScientific Research Institute for System Analysis of the Russian Academy of Sciences\u201d, Moscow 117218, Russia"},{"name":"World-Class Research Center \u00abDigital Biodesign and Personalized Healthcare\u00bb, I.M Sechenov First Moscow State Medical University (Sechenov University), Moscow 119435, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2035-2340","authenticated-orcid":false,"given":"Aleksandra","family":"Bykova","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Functional and Ultrasound Diagnostics of N.V. Sklifosovsky Institute for Clinical Medicine, I.M Sechenov First Moscow State Medical University (Sechenov University), Moscow 119435, Russia"},{"name":"Federal State Institution \u201cScientific Research Institute for System Analysis of the Russian Academy of Sciences\u201d, Moscow 117218, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5296-9313","authenticated-orcid":false,"given":"Nadezhda","family":"Potemkina","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Functional and Ultrasound Diagnostics of N.V. Sklifosovsky Institute for Clinical Medicine, I.M Sechenov First Moscow State Medical University (Sechenov University), Moscow 119435, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Chashkina","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Functional and Ultrasound Diagnostics of N.V. Sklifosovsky Institute for Clinical Medicine, I.M Sechenov First Moscow State Medical University (Sechenov University), Moscow 119435, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5473-3101","authenticated-orcid":false,"given":"Zaki Z. A.","family":"Fashafsha","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Functional and Ultrasound Diagnostics of N.V. Sklifosovsky Institute for Clinical Medicine, I.M Sechenov First Moscow State Medical University (Sechenov University), Moscow 119435, Russia"},{"name":"World-Class Research Center \u00abDigital Biodesign and Personalized Healthcare\u00bb, I.M Sechenov First Moscow State Medical University (Sechenov University), Moscow 119435, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3541-6041","authenticated-orcid":false,"given":"Dinara","family":"Mesitskaya","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Functional and Ultrasound Diagnostics of N.V. Sklifosovsky Institute for Clinical Medicine, I.M Sechenov First Moscow State Medical University (Sechenov University), Moscow 119435, Russia"},{"name":"Federal State Institution \u201cScientific Research Institute for System Analysis of the Russian Academy of Sciences\u201d, Moscow 117218, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0243-6724","authenticated-orcid":false,"given":"Nana","family":"Gogiberidze","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Functional and Ultrasound Diagnostics of N.V. Sklifosovsky Institute for Clinical Medicine, I.M Sechenov First Moscow State Medical University (Sechenov University), Moscow 119435, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9315-3801","authenticated-orcid":false,"given":"Anna","family":"Levshina","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Functional and Ultrasound Diagnostics of N.V. Sklifosovsky Institute for Clinical Medicine, I.M Sechenov First Moscow State Medical University (Sechenov University), Moscow 119435, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilya","family":"Giverts","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, MA 02114, USA"},{"name":"Maimonides Medical Center, New York, NY 11219, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8209-2791","authenticated-orcid":false,"given":"Dmitry","family":"Shchekochikhin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Functional and Ultrasound Diagnostics of N.V. Sklifosovsky Institute for Clinical Medicine, I.M Sechenov First Moscow State Medical University (Sechenov University), Moscow 119435, Russia"},{"name":"Pirogov\u2019s First Moscow City Hospital, Moscow 119002, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0276-7374","authenticated-orcid":false,"given":"Denis","family":"Andreev","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Functional and Ultrasound Diagnostics of N.V. Sklifosovsky Institute for Clinical Medicine, I.M Sechenov First Moscow State Medical University (Sechenov University), Moscow 119435, Russia"},{"name":"Federal State Institution \u201cScientific Research Institute for System Analysis of the Russian Academy of Sciences\u201d, Moscow 117218, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"ref_1","unstructured":"PDQ\u00ae Pediatric Treatment Editorial Board (2023, September 05). PDQ Late Effects of Treatment for Childhood Cancer, Available online: https:\/\/www.cancer.gov\/types\/childhood-cancers\/late-effects-hp-pdq."},{"key":"ref_2","unstructured":"(2023, September 05). Childhood Cancer Survivor Study: An Overview Was Originally Published by the National Cancer Institute. 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