{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:28:06Z","timestamp":1789446486855,"version":"build-2803163510"},"reference-count":115,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>A notable increase in direct oral anticoagulant (DOAC) use has been observed in the last decade. This trend has surpassed the prescription of vitamin K antagonists (VKAs) due to the absence of the need for regular laboratory monitoring and the more favorable characteristics in terms of efficacy and safety. However, it is very common that patients on DOACs need an interventional or surgical procedure, requiring a careful evaluation and a challenging approach. Therefore, perioperative anticoagulation management of patients on DOACs represents a growing concern for clinicians. Indeed, while several surgical interventions require temporary discontinuation of DOACs, other procedures that involve a lower risk of bleeding can be conducted, maintaining a minimal or uninterrupted DOAC strategy. Therefore, a comprehensive evaluation of patient characteristics, including age, susceptibility to stroke, previous bleeding complications, concurrent medications, renal and hepatic function, and other factors, in addition to surgical considerations, is mandatory to establish the optimal discontinuation and resumption timing of DOACs. A multidisciplinary approach is required for managing perioperative anticoagulation in order to establish how to face these circumstances. This narrative review aims to provide physicians with a practical guide for DOAC perioperative management, addressing the most controversial issues.<\/jats:p>","DOI":"10.3390\/jcm13113076","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T06:59:04Z","timestamp":1716533944000},"page":"3076","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exploring the Perioperative Use of DOACs, off the Beaten Track"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5369-5382","authenticated-orcid":false,"given":"Fabiana","family":"Luc\u00e0","sequence":"first","affiliation":[{"name":"Cardiology Department, Grande Ospedale Metropolitano, GOM, AO Bianchi Melacrino Morelli, 89124 Reggio Calabria, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Oliva","sequence":"additional","affiliation":[{"name":"Cardiology Unit, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1915-585X","authenticated-orcid":false,"given":"Simona","family":"Giubilato","sequence":"additional","affiliation":[{"name":"Cardiology Department, Cannizzaro Hospital, 95126 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0237-7157","authenticated-orcid":false,"given":"Maurizio Giuseppe","family":"Abrignani","sequence":"additional","affiliation":[{"name":"Operative Unit of Cardiology, P. 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Med., 11.","DOI":"10.3390\/jcm11051176"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1093\/europace\/euab065","article-title":"2021 European Heart Rhythm Association Practical Guide on the Use of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation","volume":"23","author":"Steffel","year":"2021","journal-title":"Europace"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ijcard.2018.05.060","article-title":"Major bleeding with old and novel oral anticoagulants: How to manage it. Focus on reversal agents","volume":"268","author":"Benvenuto","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ijcard.2018.05.061","article-title":"Major bleeding with old and novel oral anticoagulants: How to manage it. Focus on general measures","volume":"268","author":"Benvenuto","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3826","DOI":"10.1093\/eurheartj\/ehac270","article-title":"2022 ESC Guidelines on cardiovascular assessment and management of patients undergoing non-cardiac surgery","volume":"43","author":"Halvorsen","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1093\/eurheartj\/eht557","article-title":"Peri-interventional management of novel oral anticoagulants in daily care: Results from the prospective Dresden NOAC registry","volume":"35","author":"Gelbricht","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","article-title":"2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC","volume":"42","author":"Hindricks","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Luc\u00e0, F., Oliva, F., Abrignani, M.G., Di Fusco, S.A., Parrini, I., Canale, M.L., Giubilato, S., Cornara, S., Nesti, M., and Rao, C.M. (2023). Management of Patients Treated with Direct Oral Anticoagulants in Clinical Practice and Challenging Scenarios. J. Clin. Med., 12.","DOI":"10.3390\/jcm12185955"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1161\/STROKEAHA.114.007199","article-title":"Stroke and major bleeding risk in elderly patients aged \u226575 years with atrial fibrillation: The Loire Valley atrial fibrillation project","volume":"46","author":"Lip","year":"2015","journal-title":"Stroke"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1136\/heartjnl-2019-315065","article-title":"Female sex as a risk factor for ischaemic stroke varies with age in patients with atrial fibrillation","volume":"106","author":"Wu","year":"2020","journal-title":"Heart"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1161\/CIRCULATIONAHA.117.029081","article-title":"Female Sex Is a Risk Modifier Rather Than a Risk Factor for Stroke in Atrial Fibrillation: Should We Use a CHA(2)DS(2)-VA Score Rather Than CHA(2)DS(2)-VASc?","volume":"137","author":"Nielsen","year":"2018","journal-title":"Circulation"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1182\/bloodadvances.2020002335","article-title":"Predictors of preprocedural direct oral anticoagulant levels in patients having an elective surgery or procedure","volume":"4","author":"Shaw","year":"2020","journal-title":"Blood Adv."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1378\/chest.10-0134","article-title":"A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: The Euro Heart Survey","volume":"138","author":"Pisters","year":"2010","journal-title":"Chest"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1016\/j.amjcard.2015.08.049","article-title":"Stroke Risk Factors Beyond the CHA2DS2-VASc Score: Can We Improve Our Identification of \u201cHigh Stroke Risk\u201d Patients With Atrial Fibrillation?","volume":"116","author":"Szymanski","year":"2015","journal-title":"Am. J. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e012697","DOI":"10.1161\/JAHA.119.012697","article-title":"Identification of Markers Associated With Development of Stroke in \u201cClinically Low-Risk\u201d Atrial Fibrillation Patients","volume":"8","author":"Shin","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1373\/clinchem.2016.255182","article-title":"Application of Biomarkers for Risk Stratification in Patients with Atrial Fibrillation","volume":"63","author":"Hijazi","year":"2017","journal-title":"Clin. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"100972","DOI":"10.1016\/j.jacadv.2024.100972","article-title":"Understanding Atrial Fibrillation in the Context of Body Fat Distribution\u2217","volume":"3","author":"Tamirisa","year":"2024","journal-title":"JACC Adv."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Luc\u00e0, F., Oliva, F., Rao, C.M., Abrignani, M.G., Amico, A.F., Di Fusco, S.A., Caretta, G., Di Matteo, I., Di Nora, C., and Pilleri, A. (2023). Appropriateness of Dyslipidemia Management Strategies in Post-Acute Coronary Syndrome: A 2023 Update. Metabolites, 13.","DOI":"10.3390\/metabo13080916"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.jacbts.2024.01.002","article-title":"Atrial Metabolic Stress","volume":"9","author":"Schindler","year":"2024","journal-title":"JACC Basic Transl. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Moula, A.I., Parrini, I., Tetta, C., Luc\u00e0, F., Parise, G., Rao, C.M., Mauro, E., Parise, O., Matteucci, F., and Gulizia, M.M. (2022). Obstructive Sleep Apnea and Atrial Fibrillation. J. Clin. Med., 11.","DOI":"10.3390\/jcm11051242"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Coylewright, M., Cibotti-Sun, M., and Moore, M.M. (J. Am. Coll. Cardiol., 2024). 2024 Hypertrophic Cardiomyopathy Guideline-at-a-Glance, J. Am. Coll. Cardiol., in press.","DOI":"10.1016\/j.jacc.2024.04.002"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Witteles, R., Jefferies, J.L., Kapa, S., Cappelli, F., Sultan, M.B., Gundapaneni, B., Davis, M.K., and Garcia-Pavia, P. (JACC CardioOncol., 2024). Atrial Fibrillation as a Prognostic Factor for All-Cause Mortality in Patients With Transthyretin Amyloid Cardiomyopathy, JACC CardioOncol., in press.","DOI":"10.1016\/j.jaccao.2024.03.007"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Iorio, A., Luc\u00e0, F., Pozzi, A., Rao, C.M., Chimenti, C., Di Fusco, S.A., Rossini, R., Caretta, G., Cornara, S., and Giubilato, S. (2024). Anderson-Fabry Disease: Red Flags for Early Diagnosis of Cardiac Involvement. Diagnostics, 14.","DOI":"10.3390\/diagnostics14020208"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Pino, P.G., Madeo, A., Luc\u00e0, F., Ceravolo, R., di Fusco, S.A., Benedetto, F.A., Bisignani, G., Oliva, F., Colivicchi, F., and Gulizia, M.M. (2023). Clinical Utility of Three-Dimensional Echocardiography in the Evaluation of Mitral Valve Disease: Tips and Tricks. J. Clin. Med., 12.","DOI":"10.3390\/jcm12072522"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1337853","DOI":"10.3389\/fcvm.2024.1337853","article-title":"A nomogram for predicting left atrial thrombus or spontaneous echo contrast in non-valvular atrial fibrillation patients using hemodynamic parameters from transthoracic echocardiography","volume":"11","author":"Zeng","year":"2024","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Luc\u00e0, F., Giubilato, S., Di Fusco, S.A., Piccioni, L., Rao, C.M., Iorio, A., Cipolletta, L., D\u2019Elia, E., Gelsomino, S., and Rossini, R. (2021). Anticoagulation in Atrial Fibrillation Cardioversion: What Is Crucial to Take into Account. J. Clin. Med., 10.","DOI":"10.3390\/jcm10153212"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e017157","DOI":"10.1136\/bmjopen-2017-017157","article-title":"Improved risk stratification of patients with atrial fibrillation: An integrated GARFIELD-AF tool for the prediction of mortality, stroke and bleed in patients with and without anticoagulation","volume":"7","author":"Fox","year":"2017","journal-title":"BMJ Open"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e022478","DOI":"10.1136\/bmjopen-2018-022478","article-title":"Risk factors for thromboembolic and bleeding events in anticoagulated patients with atrial fibrillation: The prospective, multicentre observational PREvention oF thromboembolic events\u2014European Registry in Atrial Fibrillation (PREFER in AF)","volume":"9","author":"Rohla","year":"2019","journal-title":"BMJ Open"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/clc.22435","article-title":"The HAS-BLED Score for Predicting Major Bleeding Risk in Anticoagulated Patients With Atrial Fibrillation: A Systematic Review and Meta-analysis","volume":"38","author":"Zhu","year":"2015","journal-title":"Clin. Cardiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1016\/S0140-6736(16)00741-8","article-title":"The novel biomarker-based ABC (age, biomarkers, clinical history)-bleeding risk score for patients with atrial fibrillation: A derivation and validation study","volume":"387","author":"Hijazi","year":"2016","journal-title":"Lancet"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jvs.2006.10.034","article-title":"Risk factors and clinical impact of postoperative symptomatic venous thromboembolism","volume":"45","author":"Gangireddy","year":"2007","journal-title":"J. Vasc. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.amjsurg.2009.10.006","article-title":"Risk assessment as a guide for the prevention of the many faces of venous thromboembolism","volume":"199","author":"Caprini","year":"2010","journal-title":"Am. J. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1223660","DOI":"10.3389\/fcvm.2023.1223660","article-title":"Cancer survivorship at heart: A multidisciplinary cardio-oncology roadmap for healthcare professionals","volume":"10","author":"Bisceglia","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1055\/s-0038-1636534","article-title":"Incident Risk Factors and Major Bleeding in Patients with Atrial Fibrillation Treated with Oral Anticoagulants: A Comparison of Baseline, Follow-up and Delta HAS-BLED Scores with an Approach Focused on Modifiable Bleeding Risk Factors","volume":"118","author":"Chao","year":"2018","journal-title":"Thromb. Haemost."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1001\/archinte.159.7.677","article-title":"Choosing antithrombotic therapy for elderly patients with atrial fibrillation who are at risk for falls","volume":"159","author":"Nichol","year":"1999","journal-title":"Arch. Intern. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ijcard.2017.11.025","article-title":"Major bleeding and intracranial hemorrhage risk prediction in patients with atrial fibrillation: Attention to modifiable bleeding risk factors or use of a bleeding risk stratification score? A nationwide cohort study","volume":"254","author":"Chao","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.amjmed.2017.09.009","article-title":"Comparing Bleeding Risk Assessment Focused on Modifiable Risk Factors Only Versus Validated Bleeding Risk Scores in Atrial Fibrillation","volume":"131","author":"Guo","year":"2018","journal-title":"Am. J. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1061618","DOI":"10.3389\/fcvm.2023.1061618","article-title":"Management of oral anticoagulant therapy after intracranial hemorrhage in patients with atrial fibrillation","volume":"10","author":"Colivicchi","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1055\/s-0038-1675400","article-title":"Predicting Thromboembolic and Bleeding Event Risk in Patients with Non-Valvular Atrial Fibrillation: A Systematic Review","volume":"118","author":"Borre","year":"2018","journal-title":"Thromb. Haemost."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1055\/s-0038-1675401","article-title":"Should the Presence or Extent of Coronary Artery Disease be Quantified in the CHA2DS2-VASc Score in Atrial Fibrillation? A Report from the Western Denmark Heart Registry","volume":"118","author":"Steensig","year":"2018","journal-title":"Thromb. Haemost."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10840-014-9930-y","article-title":"Performance of the HAS-BLED high bleeding-risk category, compared to ATRIA and HEMORR2HAGES in patients with atrial fibrillation: A systematic review and meta-analysis","volume":"40","author":"Caldeira","year":"2014","journal-title":"J. Interv. Card. Electrophysiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.ahj.2005.04.017","article-title":"Clinical classification schemes for predicting hemorrhage: Results from the National Registry of Atrial Fibrillation (NRAF)","volume":"151","author":"Gage","year":"2006","journal-title":"Am. Heart J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jacc.2011.03.031","article-title":"A new risk scheme to predict warfarin-associated hemorrhage: The ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) Study","volume":"58","author":"Fang","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_44","first-page":"3258","article-title":"The ORBIT bleeding score: A simple bedside score to assess bleeding risk in atrial fibrillation","volume":"36","author":"Simon","year":"2015","journal-title":"Eur. Heart J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e000931","DOI":"10.1136\/openhrt-2018-000931","article-title":"New score for assessing bleeding risk in patients with atrial fibrillation treated with NOACs","volume":"5","author":"Rutherford","year":"2018","journal-title":"Open Heart"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.amjcard.2019.07.005","article-title":"External Validation of the ORBIT Bleeding Score and the HAS-BLED Score in Nonvalvular Atrial Fibrillation Patients Using Direct Oral Anticoagulants (Asian Data from the DIRECT Registry)","volume":"124","author":"Mori","year":"2019","journal-title":"Am. J. Cardiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/jth.14692","article-title":"Accuracy of HAS-BLED and other bleeding risk assessment tools in predicting major bleeding events in atrial fibrillation: A network meta-analysis","volume":"18","author":"Chang","year":"2020","journal-title":"J. Thromb. Haemost."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.jacc.2012.06.019","article-title":"Performance of the HEMORR2HAGES, ATRIA, and HAS-BLED bleeding risk\u2013prediction scores in patients with atrial fibrillation undergoing anticoagulation: The AMADEUS (Evaluating the Use of SR34006 Compared to Warfarin or Acenocoumarol in Patients With Atrial Fibrillation) Study","volume":"60","author":"Apostolakis","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Piccini, J.P., and Singer, D.E. (2012). Putting Risk Prediction in Atrial Fibrillation into Perspective, Oxford University Press.","DOI":"10.1093\/eurheartj\/ehs031"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1161\/CIR.0000000000000665","article-title":"2019 AHA\/ACC\/HRS focused update of the 2014 AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation: A report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society in collaboration with the Society of Thoracic Surgeons","volume":"140","author":"January","year":"2019","journal-title":"Circulation"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1161\/CIRCULATIONAHA.123.064556","article-title":"Development and Validation of the DOAC Score: A Novel Bleeding Risk Prediction Tool for Patients With Atrial Fibrillation on Direct-Acting Oral Anticoagulants","volume":"148","author":"Aggarwal","year":"2023","journal-title":"Circulation"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/jth.13904","article-title":"Chronic kidney disease and bleeding risk in patients at high cardiovascular risk: A cohort study","volume":"16","author":"Ocak","year":"2018","journal-title":"J. Thromb. Haemost."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1016\/j.jacc.2017.03.600","article-title":"Non\u2013vitamin K antagonist oral anticoagulant dosing in patients with atrial fibrillation and renal dysfunction","volume":"69","author":"Yao","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e009766","DOI":"10.1161\/JAHA.118.009766","article-title":"Predicting Bleeding Events in Anticoagulated Patients With Atrial Fibrillation: A Comparison Between the HAS-BLED and GARFIELD-AF Bleeding Scores","volume":"7","author":"Proietti","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1161\/CIRCULATIONAHA.118.038312","article-title":"Performance of the ABC Scores for Assessing the Risk of Stroke or Systemic Embolism and Bleeding in Patients With Atrial Fibrillation in ENGAGE AF-TIMI 48","volume":"139","author":"Berg","year":"2019","journal-title":"Circulation"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1177\/1074248420923528","article-title":"The Combination of Oral Anticoagulant and Antiplatelet Therapies: Stay One Step Ahead","volume":"25","author":"Giubilato","year":"2020","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nrneph.2018.19","article-title":"Use of oral anticoagulants in patients with atrial fibrillation and renal dysfunction","volume":"14","author":"Potpara","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1055\/s-0038-1666861","article-title":"Concepts and Controversies in Haemostasis and Thrombosis Associated with Liver Disease: Proceedings of the 7th International Coagulation in Liver Disease Conference","volume":"118","author":"Intagliata","year":"2018","journal-title":"Thromb. Haemost."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1111\/liv.14992","article-title":"Safety of direct oral anticoagulants in patients with advanced liver disease","volume":"41","author":"Semmler","year":"2021","journal-title":"Liver Int."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1016\/j.cgh.2023.04.016","article-title":"Bleeding and Thrombotic Complications in Patients With Cirrhosis: A State-of-the-Art Appraisal","volume":"21","author":"Rautou","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/S0735-1097(98)00146-6","article-title":"Transesophageal echocardiographic correlates of clinical risk of thromboembolism in nonvalvular atrial fibrillation. Stroke Prevention in Atrial Fibrillation III Investigators","volume":"31","author":"Zabalgoitia","year":"1998","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_62","first-page":"e35","article-title":"2020 ACC\/AHA Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"143","author":"Otto","year":"2021","journal-title":"Circulation"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1016\/j.jacc.2018.07.098","article-title":"Stroke Risk Stratification for Atrial Fibrillation Patients With Hypertrophic Cardiomyopathy","volume":"72","author":"Jung","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Parrini, I., Luc\u00e0, F., Rao, C.M., Parise, G., Micali, L.R., Musumeci, G., La Meir, M., Colivicchi, F., Gulizia, M.M., and Gelsomino, S. (2022). Superiority of Direct Oral Anticoagulants over Vitamin K Antagonists in Oncological Patients with Atrial Fibrillation: Analysis of Efficacy and Safety Outcomes. J. Clin. Med., 11.","DOI":"10.3390\/jcm11195712"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Mauro, E., Luc\u00e0, F., Tetta, C., Parise, O., Parrini, I., Parise, G., Rao, C.M., Matteucci, F., Micali, L.R., and Gulizia, M.M. (2022). Breast Cancer and Atrial Fibrillation. J. Clin. Med., 11.","DOI":"10.3390\/jcm11051417"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Luc\u00e0, F., Parrini, I., Abrignani, M.G., Rao, C.M., Piccioni, L., Di Fusco, S.A., Ceravolo, R., Bisceglia, I., Riccio, C., and Gelsomino, S. (2022). Management of Acute Coronary Syndrome in Cancer Patients: It\u2019s High Time We Dealt with It. J. Clin. Med., 11.","DOI":"10.3390\/jcm11071792"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/hon.2503","article-title":"Practical management of ibrutinib in the real life: Focus on atrial fibrillation and bleeding","volume":"36","author":"Boriani","year":"2018","journal-title":"Hematol. Oncol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/europace\/eut312","article-title":"Increased risk of atrial fibrillation and stroke during active stages of inflammatory bowel disease: A nationwide study","volume":"16","author":"Kristensen","year":"2014","journal-title":"Europace"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.ijcard.2016.08.297","article-title":"Atrial fibrillation, liver disease, antithrombotics and risk of cerebrovascular events: A population-based cohort study","volume":"223","author":"Lai","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1056\/NEJMoa1915152","article-title":"Anticoagulation with or without Clopidogrel after Transcatheter Aortic-Valve Implantation","volume":"382","author":"Nijenhuis","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1093\/eurheartj\/ehx403","article-title":"Predictors of pre-procedural concentrations of direct oral anticoagulants: A prospective multicentre study","volume":"38","author":"Godier","year":"2017","journal-title":"Eur. Heart J."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Pozzi, A., Luc\u00e0, F., Gelsomino, S., Abrignani, M.G., Giubilato, S., Di Fusco, S.A., Rao, C.M., Cornara, S., Caretta, G., and Ceravolo, R. (2024). Coagulation Tests and Reversal Agents in Patients Treated with Oral Anticoagulants: The Challenging Scenarios of Life-Threatening Bleeding and Unplanned Invasive Procedures. J. Clin. Med., 13.","DOI":"10.3390\/jcm13092451"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1056\/NEJMoa1707278","article-title":"Idarucizumab for Dabigatran Reversal\u2014Full Cohort Analysis","volume":"377","author":"Pollack","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1056\/NEJMoa1814051","article-title":"Full Study Report of Andexanet Alfa for Bleeding Associated with Factor Xa Inhibitors","volume":"380","author":"Connolly","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1182\/blood-2012-06-415943","article-title":"How I treat anticoagulated patients undergoing an elective procedure or surgery","volume":"120","author":"Spyropoulos","year":"2012","journal-title":"Blood"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1056\/NEJMoa1501035","article-title":"Perioperative Bridging Anticoagulation in Patients with Atrial Fibrillation","volume":"373","author":"Douketis","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1160\/TH17-08-0553","article-title":"The Perioperative Anticoagulant Use for Surgery Evaluation (PAUSE) Study for Patients on a Direct Oral Anticoagulant Who Need an Elective Surgery or Procedure: Design and Rationale","volume":"117","author":"Douketis","year":"2017","journal-title":"Thromb. Haemost."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e326S","DOI":"10.1378\/chest.11-2298","article-title":"Perioperative management of antithrombotic therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines","volume":"141","author":"Douketis","year":"2012","journal-title":"Chest"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1161\/CIRCULATIONAHA.111.090464","article-title":"Periprocedural bleeding and thromboembolic events with dabigatran compared with warfarin: Results from the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) randomized trial","volume":"126","author":"Healey","year":"2012","journal-title":"Circulation"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1055\/s-0038-1645856","article-title":"Peri-operative Adverse Outcomes in Patients with Atrial Fibrillation Taking Warfarin or Edoxaban: Analysis of the ENGAGE AF-TIMI 48 Trial","volume":"118","author":"Douketis","year":"2018","journal-title":"Thromb. Haemost."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jjcc.2019.02.003","article-title":"Clinical comparative study regarding interrupted and uninterrupted dabigatran therapy during perioperative periods of cryoballoon ablation for paroxysmal atrial fibrillation","volume":"74","author":"Nakamura","year":"2019","journal-title":"J. Cardiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1182\/blood-2014-08-595496","article-title":"Management and clinical outcomes in patients treated with apixaban vs warfarin undergoing procedures","volume":"124","author":"Garcia","year":"2014","journal-title":"Blood"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.jacep.2017.11.005","article-title":"A Prospective Randomized Trial of Apixaban Dosing During Atrial Fibrillation Ablation: The AEIOU Trial","volume":"4","author":"Reynolds","year":"2018","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"3973","DOI":"10.1093\/eurheartj\/ehy413","article-title":"Continued vs. interrupted direct oral anticoagulants at the time of device surgery, in patients with moderate to high risk of arterial thrombo-embolic events (BRUISE CONTROL-2)","volume":"39","author":"Birnie","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1161\/CIRCULATIONAHA.113.005754","article-title":"Outcomes of temporary interruption of rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: Results from the rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation (ROCKET AF)","volume":"129","author":"Sherwood","year":"2014","journal-title":"Circulation"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1001\/jamainternmed.2019.2431","article-title":"Perioperative Management of Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant","volume":"179","author":"Douketis","year":"2019","journal-title":"JAMA Intern. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1111\/jth.13670","article-title":"Thrombotic and bleeding outcomes following perioperative interruption of direct oral anticoagulants in patients with venous thromboembolic disease","volume":"15","author":"Shaw","year":"2017","journal-title":"J. Thromb. Haemost."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/jth.14468","article-title":"Periprocedural interruption of anticoagulation in patients with cancer-associated venous thromboembolism: An analysis of thrombotic and bleeding outcomes","volume":"17","author":"Shaw","year":"2019","journal-title":"J. Thromb. Haemost."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"e146","DOI":"10.1016\/j.oooo.2016.06.003","article-title":"Management of dental extraction in patients undergoing anticoagulant oral direct treatment: A pilot study","volume":"122","author":"Mauprivez","year":"2016","journal-title":"Oral. Surg. Oral. Med. Oral. Pathol. Oral. Radiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/sj.bdj.2017.165","article-title":"Managing direct oral anticoagulants in patients undergoing dentoalveolar surgery","volume":"222","author":"Patel","year":"2017","journal-title":"Br. Dent. J."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"e015952","DOI":"10.1136\/bmjopen-2017-015952","article-title":"Risks of postextraction bleeding after receiving direct oral anticoagulants or warfarin: A retrospective cohort study","volume":"7","author":"Yagyuu","year":"2017","journal-title":"BMJ Open"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.accpm.2016.09.002","article-title":"Management of direct oral anticoagulants in patients undergoing elective surgeries and invasive procedures: Updated guidelines from the French Working Group on Perioperative Hemostasis (GIHP)\u2014September 2015","volume":"36","author":"Albaladejo","year":"2017","journal-title":"Anaesth. Crit. Care Pain Med."},{"key":"ref_93","first-page":"225","article-title":"Interventional Spine and Pain Procedures in Patients on Antiplatelet and Anticoagulant Medications (Second Edition): Guidelines From the American Society of Regional Anesthesia and Pain Medicine, the European Society of Regional Anaesthesia and Pain Therapy, the American Academy of Pain Medicine, the International Neuromodulation Society, the North American Neuromodulation Society, and the World Institute of Pain","volume":"43","author":"Narouze","year":"2018","journal-title":"Reg. Anesth. Pain. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e275","DOI":"10.1016\/j.hrthm.2017.05.012","article-title":"2017 HRS\/EHRA\/ECAS\/APHRS\/SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation","volume":"14","author":"Calkins","year":"2017","journal-title":"Heart Rhythm"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/icvts\/ivt522","article-title":"Guideline adherence in antithrombotic treatment after concomitant ablation surgery in atrial fibrillation patients","volume":"18","author":"Gelsomino","year":"2014","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1161\/CIRCULATIONAHA.117.033326","article-title":"Management of Intraprocedural Anticoagulation in Patients on Non-Vitamin K Antagonist Oral Anticoagulants Undergoing Catheter Ablation for Atrial Fibrillation: Understanding the Gaps in Evidence","volume":"138","author":"Martin","year":"2018","journal-title":"Circulation"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.hrthm.2017.09.011","article-title":"An updated meta-analysis of novel oral anticoagulants versus vitamin K antagonists for uninterrupted anticoagulation in atrial fibrillation catheter ablation","volume":"15","author":"Cardoso","year":"2018","journal-title":"Heart Rhythm."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.amjcard.2014.10.002","article-title":"RE-CIRCUIT study-randomized evaluation of Dabigatran etexilate compared to warfarin in pulmonary vein ablation: Assessment of an uninterrupted periprocedural anticoagulation strategy","volume":"115","author":"Calkins","year":"2015","journal-title":"Am. J. Cardiol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1093\/eurheartj\/ehv177","article-title":"Uninterrupted rivaroxaban vs. uninterrupted vitamin K antagonists for catheter ablation in non-valvular atrial fibrillation","volume":"36","author":"Cappato","year":"2015","journal-title":"Eur. Heart J."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1093\/eurheartj\/ehy176","article-title":"Apixaban in patients at risk of stroke undergoing atrial fibrillation ablation","volume":"39","author":"Kirchhof","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1093\/eurheartj\/ehz190","article-title":"Uninterrupted edoxaban vs. vitamin K antagonists for ablation of atrial fibrillation: The ELIMINATE-AF trial","volume":"40","author":"Hohnloser","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1093\/eurheartj\/ehy136","article-title":"The 2018 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation","volume":"39","author":"Steffel","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s10840-019-00683-z","article-title":"Ultrasound guidance for femoral venous access in electrophysiology procedures-systematic review and meta-analysis","volume":"59","author":"Pap","year":"2020","journal-title":"J. Interv. Card. Electrophysiol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1111\/jce.15893","article-title":"Ultrasound guidance for femoral venous access in patients undergoing pulmonary vein isolation: A quasi-randomized study","volume":"34","author":"Kupo","year":"2023","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s11239-015-1282-7","article-title":"Laboratory measurement of the non-vitamin K antagonist oral anticoagulants: Selecting the optimal assay based on drug, assay availability, and clinical indication","volume":"41","author":"Cuker","year":"2016","journal-title":"J. Thromb. Thrombolysis"},{"key":"ref_106","first-page":"734","article-title":"Reversal agents for severe bleeding associated with direct oral anticoagulants","volume":"23","author":"Giubilato","year":"2022","journal-title":"G. Ital. Cardiol."},{"key":"ref_107","first-page":"161","article-title":"Why NAO: Know How. Why and how to choose the new oral anticoagulant in cardiological clinical practice","volume":"16","author":"Rossini","year":"2015","journal-title":"G. Ital. Cardiol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jacc.2019.05.016","article-title":"Management of Antithrombotic Therapy in Atrial Fibrillation Patients Undergoing PCI: JACC State-of-the-Art Review","volume":"74","author":"Capodanno","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1093\/eurheartj\/ehad191","article-title":"2023 ESC Guidelines for the management of acute coronary syndromes","volume":"44","author":"Byrne","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4244\/EIJV10I1A8","article-title":"Perioperative management of antiplatelet therapy in patients with coronary stents undergoing cardiac and non-cardiac surgery: A consensus document from Italian cardiological, surgical and anaesthesiological societies","volume":"10","author":"Rossini","year":"2014","journal-title":"EuroIntervention"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/eurheartj\/ehx419","article-title":"2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS: The Task Force for dual antiplatelet therapy in coronary artery disease of the European Society of Cardiology (ESC) and of the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"39","author":"Valgimigli","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1056\/NEJMoa1611594","article-title":"Prevention of Bleeding in Patients with Atrial Fibrillation Undergoing PCI","volume":"375","author":"Gibson","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1056\/NEJMoa1708454","article-title":"Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation","volume":"377","author":"Cannon","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMoa1817083","article-title":"Antithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation","volume":"380","author":"Lopes","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/S0140-6736(19)31872-0","article-title":"Edoxaban-based versus vitamin K antagonist-based antithrombotic regimen after successful coronary stenting in patients with atrial fibrillation (ENTRUST-AF PCI): A randomised, open-label, phase 3b trial","volume":"394","author":"Vranckx","year":"2019","journal-title":"Lancet"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/11\/3076\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:47:59Z","timestamp":1760107679000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/11\/3076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,24]]},"references-count":115,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["jcm13113076"],"URL":"https:\/\/doi.org\/10.3390\/jcm13113076","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,24]]}}}