{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:48:51Z","timestamp":1793148531056,"version":"4.5.0"},"reference-count":39,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Merck Sharp &amp; Dohme Corp., a subsidiary of Merck &amp; Co., Inc., Kenilworth, NJ, USA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background and objective: Chronic cough (CC) is a prevalent yet underexplored medical condition, with limited real-world data regarding its healthcare burden. This study investigates the epidemiology, associated comorbidities, and healthcare service utilization among patients with CC. Methods: In this retrospective cohort study, adult patients with at least 3 physician diagnoses of cough over a period spanning a minimum of 8 weeks and a maximum of 12 months anytime between 2009 and 2018, were defined as patients with CC (PwCC). The reference group were adults without cough matched in a 1:1 ratio for age, sex, and place of residence. Results: The study included 91,757 PwCC, reflecting a prevalence of 5.5%. Of those, 59,296 patients (mean [SD] age, 53.9 [16.8] years; 59.6% females) were first diagnosed with CC during the study period, representing a 10-year incidence rate of 3.26% (95%CI: 3.24\u20133.29%). Diseases associated with the highest OR for CC included lung cancer (OR = 3.32; 95%CI: 2.90\u20134.25), whooping cough (OR = 3.04; 95%CI: 2.70\u20133.60), and respiratory infections (OR = 2.81; 95%CI: 2.74\u20132.88). Furthermore, PwCC demonstrated increased healthcare service utilization, leading to a higher adjusted annual estimated mean cost (USD 4038 vs. USD 1833, p &lt; 0.001). Conclusions: Chronic cough emerges as a relatively prevalent complaint within community care, exerting a considerable economic burden. This study underscores the need for heightened awareness, comprehensive management strategies, and resource allocation to address the multifaceted challenges associated with chronic cough.<\/jats:p>","DOI":"10.3390\/jcm13113230","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T08:15:54Z","timestamp":1717056954000},"page":"3230","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Epidemiology and Healthcare Service Utilization among Adults with Chronic Cough"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5189-8995","authenticated-orcid":false,"given":"Gabriel","family":"Chodick","sequence":"first","affiliation":[{"name":"Maccabitech, Maccabi Institute for Research and Innovation, Maccabi Healthcare Services, Ha\u2019Mered St. 27, Tel Aviv 6812509, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, P.O. Box 39040, Ramat Aviv, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3264-3380","authenticated-orcid":false,"given":"Yael","family":"Barer","sequence":"additional","affiliation":[{"name":"Maccabitech, Maccabi Institute for Research and Innovation, Maccabi Healthcare Services, Ha\u2019Mered St. 27, Tel Aviv 6812509, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Blay Hagai","sequence":"additional","affiliation":[{"name":"Global Medical and Scientific Affairs, Merck Sharp & Dohme Company Ltd., Ha\u2019Charash St. 34, P.O. Box 7340, Hod Hasharon 45800, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ido","family":"Keidar","sequence":"additional","affiliation":[{"name":"Global Medical and Scientific Affairs, Merck Sharp & Dohme Company Ltd., Ha\u2019Charash St. 34, P.O. Box 7340, Hod Hasharon 45800, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8340-6041","authenticated-orcid":false,"given":"Gally","family":"Rosenfeld Teper","sequence":"additional","affiliation":[{"name":"Global Medical and Scientific Affairs, Merck Sharp & Dohme Company Ltd., Ha\u2019Charash St. 34, P.O. Box 7340, Hod Hasharon 45800, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagit","family":"Kopel","sequence":"additional","affiliation":[{"name":"Global Medical and Scientific Affairs, Merck Sharp & Dohme Company Ltd., Ha\u2019Charash St. 34, P.O. Box 7340, Hod Hasharon 45800, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9234-4710","authenticated-orcid":false,"given":"Neville","family":"Berkman","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Kalman Ya\u2019Akov Man Street, Ein-Karem, Jerusalem 9112102, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4168\/aair.2016.8.2.146","article-title":"Defining chronic cough: A systematic review of the epidemiological literature","volume":"8","author":"Song","year":"2016","journal-title":"Allergy Asthma Immunol. 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