{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:08:38Z","timestamp":1760144918684,"version":"build-2065373602"},"reference-count":56,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: A growing body of evidence highlights the effects of air pollution on chronic and acute cardiovascular diseases, such as associations between PM10 and several cardiovascular events. However, evidence of the impact of fine air pollutants on the development and progression of peripheral arterial aneurysms is not available. Methods: Data were obtained from the multicenter PAA outcome registry POPART and the German Environment Agency. Means of the mean daily concentration of PM10, PM2.5, NO2, and O3 concentrations were calculated for 2, 10, and 3650 days prior to surgery for each patient. Additionally, weighted ten-year averages were analyzed. Correlation was assessed by calculating Pearson correlation coefficients, and regression analyses were conducted as multiple linear or multiple logistic regression, depending on the dependent variable. Results: For 1193 patients from the POPART registry, paired air pollution data were available. Most patients were male (95.6%) and received open surgical repair (89.9%). On a regional level, the arithmetic means of the daily means of PM10 between 2000 and 2022 were neither associated with average diameters nor runoff vessels. Negative correlations for mean PAA diameter and mean NO2, as well as a positive correlation with mean O3, were found; however, they were not statistically significant. On patient level, no evidence for an association of mean PM10 exposure over ten years prior to inclusion in the registry and PAA diameter or the number of runoff vessels was found. Weighted PM10, NO2, and O3 exposure over ten years also did not result in significant associations with aneurysm diameter or runoff vessels. Short-term air pollutant concentrations were not associated with symptomatic PAAs or with perioperative complications. Conclusions: We found no indication that long-term air pollutant concentrations are associated with PAA size or severity, neither on a regional nor individual level. Additionally, short-term air pollution showed no association with clinical presentation or treatment outcomes.<\/jats:p>","DOI":"10.3390\/jcm13113250","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T11:43:48Z","timestamp":1717155828000},"page":"3250","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Effects of Local Air Pollution on Popliteal Artery Aneurysms"],"prefix":"10.3390","volume":"13","author":[{"given":"Maria Elisabeth","family":"Leinweber","sequence":"first","affiliation":[{"name":"FIFOS\u2014Forum for Integrative Research and Systems Biology, 1170 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Meisenbacher","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, University Hospital Heidelberg, 69120 Heidelberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Schmandra","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Sana Klinikum Offenbach, 63069 Offenbach, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Karl","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Klinikum am Plattenwald, SLK-Kliniken Heilbronn GmbH, 74177 Bad Friedrichshall, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Torsello","sequence":"additional","affiliation":[{"name":"Department for Vascular Surgery, Franziskus Hospital M\u00fcnster, 48145 M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikolaj","family":"Walensi","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery and Phlebology, Contilia Heart and Vascular Center, 45138 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip","family":"Geisbuesch","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Klinikum Stuttgart, 70199 Stuttgart, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6082-0006","authenticated-orcid":false,"given":"Thomas","family":"Schmitz-Rixen","sequence":"additional","affiliation":[{"name":"German Society of Surgery, Langenbeck-Virchow-Haus, Luisenstra\u00dfe 58\/59, 10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5509-357X","authenticated-orcid":false,"given":"Georg","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Luzerner Kantonsspital, 6000 Lucern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8264-7796","authenticated-orcid":false,"given":"Amun Georg","family":"Hofmann","sequence":"additional","affiliation":[{"name":"FIFOS\u2014Forum for Integrative Research and Systems Biology, 1170 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1161\/01.CIR.0000128587.30041.C8","article-title":"Air Pollution and Cardiovascular Disease: A Statement for Healthcare Professionals from the Expert Panel on Population and Prevention Science of the American Heart Association","volume":"109","author":"Brook","year":"2004","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1136\/heartjnl-2013-304963","article-title":"Short-term effects of air pollution on a range of cardiovascular events in England and Wales: Case-crossover analysis of the MINAP database, hospital admissions and mortality","volume":"100","author":"Milojevic","year":"2014","journal-title":"Heart"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1600419","DOI":"10.1183\/13993003.00419-2016","article-title":"A joint ERS\/ATS policy statement: What constitutes an adverse health effect of air pollution? 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