{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:54:50Z","timestamp":1783036490185,"version":"3.54.6"},"reference-count":18,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Many people with pain from osteoarthritis (OA) of the knee are either not ready for surgery or may never be surgical candidates. Genicular artery embolization (GAE) is a new proposed management for those with pain despite maximum medical management. It has historically been used to manage recurrent spontaneous haemarthrosis following total knee replacement, but newer studies are showing a positive effect in managing pre-arthroplasty knee OA. The goal of this review is to summarise current and relevant literature from searches of computerised databases and relevant journals, and analyse their results. Studies included show that GAE has promising outcomes in managing mild to moderate OA knee pain in those who have exhausted at least 3 months of conservative therapy. Most studies show improvements in VAS pain and PROM scores (including KOOS, and\/or WOMAC). Minimal adverse effects have been associated in up to two years of follow up, the majority of which are self-resolving. The article pr\u00e9cises a concise general procedural technique for performing GAE, as well as comparing and contrasting different embolic agents that may be utilised. GAE shows promising outcomes in management of mild to moderate OA knee pain. In the future, there will need to be higher volume studies to determine effectiveness, suitable candidates, and other potential adverse effects.<\/jats:p>","DOI":"10.3390\/jcm13113256","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T11:43:48Z","timestamp":1717155828000},"page":"3256","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Selective Genicular Artery Embolization in the Management of Osteoarthritic Knee Pain\u2014A Narrative Review"],"prefix":"10.3390","volume":"13","author":[{"given":"Stephanie","family":"O\u2019Brien","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Royal Perth Hospital, Perth, WA 6000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William G.","family":"Blakeney","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Royal Perth Hospital, Perth, WA 6000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Radiology, Royal Perth Hospital, Perth, WA 6000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.jvir.2017.02.033","article-title":"Midterm Clinical Outcomes and MR Imaging Changes after Transcatheter Arterial Embolization as a Treatment for Mild to Moderate Radiographic Knee Osteoarthritis Resistant to Conservative Treatment","volume":"28","author":"Okuno","year":"2017","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"232596712110213","DOI":"10.1177\/23259671211021356","article-title":"Osteoarthritis-Related Knee Pain Treated with Genicular Artery Embolization: A Systematic Review and Meta-analysis","volume":"9","author":"Torkian","year":"2021","journal-title":"Orthop. J. Sports Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.knee.2022.12.008","article-title":"Two-year outcomes comparing Embosphere\u00ae microspheres versus Imipenem Cilastatin for genicular artery embolization in patients with moderate to severe knee osteoarthritis","volume":"41","author":"Bhatia","year":"2023","journal-title":"Knee"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1148\/rg.210159","article-title":"Geniculate Artery Embolization: Role in Knee Hemarthrosis and Osteoarthritis","volume":"42","author":"Heller","year":"2022","journal-title":"RadioGraphics"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.2106\/JBJS.RVW.23.00082","article-title":"Genicular Artery Embolization for Knee Osteoarthritis","volume":"11","author":"Poursalehian","year":"2023","journal-title":"JBJS Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1007\/s00270-019-02289-4","article-title":"Clinical Outcomes of Transcatheter Arterial Embolisation for Chronic Knee Pain: Mild-to-Moderate Versus Severe Knee Osteoarthritis","volume":"42","author":"Lee","year":"2019","journal-title":"CardioVasc. Interv. Radiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1016\/j.jvir.2023.08.029","article-title":"Genicular Artery Embolization for Treatment of Knee Osteoarthritis: Interim Analysis of a Prospective Pilot Trial Including Effect on Serum Osteoarthritis-Associated Biomarkers","volume":"34","author":"Taslakian","year":"2023","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00270-020-02687-z","article-title":"Genicular Artery Embolization for Osteoarthritis Related Knee Pain: A Systematic Review and Qualitative Analysis of Clinical Outcomes","volume":"44","author":"Casadaban","year":"2020","journal-title":"CardioVasc. Interv. Radiol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Russu, O., Bloj, F., Feier, A.M., Vunvulea, V., Mogo\u0219, S., Predescu, V., and Pop, T.S. (2022). At the Edge of Orthopaedics: Initial Experience with Transarterial Periarticular Embolization for Knee Osteoarthritis in a Romanian Population. J. Clin. Med., 11.","DOI":"10.3390\/jcm11216573"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jvir.2021.09.019","article-title":"Multicenter Randomized Sham Controlled Study of Genicular Artery Embolization for Knee Pain Secondary to Osteoarthritis","volume":"33","author":"Bagla","year":"2022","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.jvir.2019.09.018","article-title":"Genicular Artery Embolization for the Treatment of Knee Pain Secondary to Osteoarthritis","volume":"31","author":"Bagla","year":"2020","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/j.jvir.2020.08.012","article-title":"The Value of Preprocedural MR Imaging in Genicular Artery Embolization for Patients with Osteoarthritic Knee Pain","volume":"31","author":"Choi","year":"2020","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1302\/2633-1462.43.BJO-2022-0161.R2","article-title":"Genicular artery embolization for early-stage knee osteoarthritis: Results from a triple-blind single-centre randomized controlled trial","volume":"4","author":"Landers","year":"2023","journal-title":"Bone Jt. Open"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.2106\/JBJS.OA.21.00085","article-title":"Genicular Artery Embolization for the Treatment of Symptomatic Knee Osteoarthritis","volume":"6","author":"Padia","year":"2021","journal-title":"JBJS Open Access"},{"key":"ref_15","first-page":"795","article-title":"Efficacy analysis of selective genicular artery embolization in the treatment of knee pain secondary to osteoarthritis","volume":"102","author":"Sun","year":"2022","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"100342","DOI":"10.1016\/j.ocarto.2023.100342","article-title":"Genicular artery embolization for treatment of knee osteoarthritis pain: Systematic review and meta-analysis","volume":"5","author":"Taslakian","year":"2023","journal-title":"Osteoarthr. Cartil. 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