{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T13:18:00Z","timestamp":1772457480277,"version":"3.50.1"},"reference-count":35,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Transient hypoparathyroidism (TH) is the main post-thyroidectomy complication, significantly impacting surgical outcomes, hospitalization length, and perceived perceived quality of life understood as mental and physical well-being. This study aims to identify possible associated risk factors. Methods: We analyzed 238 thyroidectomies (2020\u20132022), excluding instances of partial surgery, primary hyperparathyroidism, neck irradiation history, and renal failure. The variables considered were as follows: demographics, histology, autoimmunity, thyroid function, pre- and postoperative Vitamin D levels (where available), type of surgery, number of incidentally removed parathyroid glands (IRP), and surgeons\u2019 experience (&gt;1000 thyroidectomies, &lt;500, in training). Univariate analysis applied: \u03c72, Fisher\u2019s exact test for categorical variables, and Student\u2019s t-test for continuous variables. Subsequently, logistic multivariate analysis with stepwise selection was performed. Results: Univariate analysis did not yield statistically significant results for the considered variables. The \u2018No Complications\u2019 group displayed a mean age of 55 years, whereas the TH group showed a mean age of 51 (p-value = 0.055). We considered this result to be marginally significant. Subsequently, we constructed a multivariate logistic model. This model (AIC = 245.02) indicated that the absence of incidental parathyroidectomy was associated with the age class &gt;55 years, presenting an odds ratio (OR) of 9.015 (p-value &lt; 0.05). Simultaneously, the age class &gt;55 years exhibited protective effects against TH, demonstrating an OR of 0.085 (p-value &lt; 0.01). Similarly, the absence of incidental parathyroidectomy was found to be protective against TH, with an OR of 0.208 (p-value &lt; 0.01). Conclusions: Multivariate analysis highlighted that having \u201cNo IRP\u201d was protective against TH, while younger age was a risk factor. Surgeon experience does not seem to correlate with IRP or outcomes, assuming there is adequate tutoring and a case volume close to 500 to ensure good results. The effect of reimplantation has not been evident in transient hypoparathyroidism.<\/jats:p>","DOI":"10.3390\/jcm13113326","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T03:49:28Z","timestamp":1717559368000},"page":"3326","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Risk Factors for Transient Hypoparathyroidism after Total Thyroidectomy: Insights from a Cohort Analysis"],"prefix":"10.3390","volume":"13","author":[{"given":"Giuseppa","family":"Graceffa","sequence":"first","affiliation":[{"name":"Unit of General and Oncology Surgery, Department of Surgical Oncological and Oral Sciences, Policlinico \u201cP. Giaccone\u201d, University of Palermo, Via Liborio Giuffr\u00e9 5, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Lopes","sequence":"additional","affiliation":[{"name":"Unit of General and Oncology Surgery, Department of Surgical Oncological and Oral Sciences, Policlinico \u201cP. Giaccone\u201d, University of Palermo, Via Liborio Giuffr\u00e9 5, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppina","family":"Orlando","sequence":"additional","affiliation":[{"name":"Unit of General and Emergency Surgery, Department of Surgical Oncological and Oral Sciences, Policlinico \u201cP. Giaccone\u201d, University of Palermo, Via Liborio Giuffr\u00e9 5, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Mazzola","sequence":"additional","affiliation":[{"name":"Unit of Clinical Epidemiology and Tumor Registry, Department of Laboratory Diagnostics, Policlinico \u201cP. Giaccone\u201d, University of Palermo, Via Liborio Giuffr\u00e9 5, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Vassallo","sequence":"additional","affiliation":[{"name":"Unit of General and Emergency Surgery, Department of Surgical Oncological and Oral Sciences, Policlinico \u201cP. Giaccone\u201d, University of Palermo, Via Liborio Giuffr\u00e9 5, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4450-1952","authenticated-orcid":false,"given":"Francesco","family":"Curione","sequence":"additional","affiliation":[{"name":"Unit of General and Emergency Surgery, Department of Surgical Oncological and Oral Sciences, Policlinico \u201cP. Giaccone\u201d, University of Palermo, Via Liborio Giuffr\u00e9 5, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierina","family":"Richiusa","sequence":"additional","affiliation":[{"name":"Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialties (PROMISE), Section of Endocrinology, University of Palermo, Via Liborio Giuffr\u00e9 5, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Radellini","sequence":"additional","affiliation":[{"name":"Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialties (PROMISE), Section of Endocrinology, University of Palermo, Via Liborio Giuffr\u00e9 5, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9439-3073","authenticated-orcid":false,"given":"Giuseppina","family":"Melfa","sequence":"additional","affiliation":[{"name":"Unit of General and Emergency Surgery, Department of Surgical Oncological and Oral Sciences, Policlinico \u201cP. Giaccone\u201d, University of Palermo, Via Liborio Giuffr\u00e9 5, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregorio","family":"Scerrino","sequence":"additional","affiliation":[{"name":"Unit of Endocrine Surgery, Department of Surgical Oncological and Oral Sciences, Policlinico \u201cP. Giaccone\u201d, University of Palermo, Via Liborio Giuffr\u00e9 5, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1002\/bjs.7219","article-title":"Outcome of protracted hypoparathyroidism after total thyroidectomy","volume":"97","author":"Ruiz","year":"2010","journal-title":"Br. J. 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