{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:17:15Z","timestamp":1785539835163,"version":"3.56.0"},"reference-count":59,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Molly Towell Perinatal Research Foundation"},{"name":"Canadian Institutes of Health Research"},{"name":"Natural Sciences and Engineering Research Council of Canada"},{"name":"Faculty of Science, Carleton University"},{"name":"Carleton University Office of Research"},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)"},{"name":"Braziland Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais (FAPEMIG), Brazil"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The placenta undergoes morphological and functional adaptations to adverse exposures during pregnancy. The effects ofsuboptimal maternal body mass index (BMI), preterm birth, and infection on placental histopathological phenotypes are not yet well understood, despite the association between these conditions and poor offspring outcomes. We hypothesized that suboptimal maternal prepregnancy BMI and preterm birth (with and without infection) would associate with altered placental maturity and morphometry, and that altered placental maturity would associate with poor birth outcomes. Methods: Clinical data and human placentae were collected from 96 pregnancies where mothers were underweight, normal weight, overweight, or obese, without other major complications. Placental histopathological characteristics were scored by an anatomical pathologist. Associations between maternal BMI, placental pathology (immaturity and hypermaturity), placental morphometry, and infant outcomes were investigated for term and preterm births with and without infection. Results: Fetal capillary volumetric proportion was decreased, whereas the villous stromal volumetric proportion was increased in placentae from preterm pregnancies with chorioamnionitis compared to preterm placentae without chorioamnionitis. At term and preterm, pregnancies with maternal overweight and obesity had a high percentage increase in proportion of immature placentae compared to normal weight. Placental maturity did not associate with infant birth outcomes. We observed placental hypermaturity and altered placental morphometry among preterm pregnancies with chorioamnionitis, suggestive of altered placental development, which may inform about pregnancies susceptible to preterm birth and infection. Conclusions: Our data increase our understanding of how common metabolic exposures and preterm birth, in the absence of other comorbidities or complications, potentially contribute to poor pregnancy outcomes and developmental programming.<\/jats:p>","DOI":"10.3390\/jcm13123378","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T08:59:06Z","timestamp":1718009946000},"page":"3378","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Gestational Age, Infection, and Suboptimal Maternal Prepregnancy BMI Independently Associate with Placental Histopathology in a Cohort of Pregnancies without Major Maternal Comorbidities"],"prefix":"10.3390","volume":"13","author":[{"given":"Eleanor","family":"Duffley","sequence":"first","affiliation":[{"name":"Department of Health Sciences, Carleton University, Ottawa, ON K1S 5B6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Grynspan","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital of Eastern Ontario, Department of Pathology, Ottawa, ON K1H 8L1, Canada"},{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailey","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Carleton University, Ottawa, ON K1S 5B6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthea","family":"Lafreni\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, The Ottawa Hospital, The University of Ottawa, Ottawa, ON K1H 8L6, Canada"},{"name":"Department of Pathology and Immunology, Baylor College of Medicine, Texas Children\u2019s Hospital, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4320-4252","authenticated-orcid":false,"given":"Cherley","family":"Borba Vieira de Andrade","sequence":"additional","affiliation":[{"name":"Histology and Embryology Department, Roberto Alcantara Gomes Institute of Biology, Rio de Janeiro State University, Rio de Janeiro 20551-030, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0275-8686","authenticated-orcid":false,"given":"Enrrico","family":"Bloise","sequence":"additional","affiliation":[{"name":"Department of Morphology, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil"},{"name":"Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin L.","family":"Connor","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Carleton University, Ottawa, ON K1S 5B6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1471-0528.2006.01180.x","article-title":"Trends in maternal obesity incidence rates, demographic predictors, and health inequalities in 36,821 women over a 15-year period","volume":"114","author":"Heslehurst","year":"2007","journal-title":"BJOG Int. 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