{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:10:19Z","timestamp":1760145019425,"version":"build-2065373602"},"reference-count":45,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Allergan, an AbbVie company"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: To assess intraocular pressure (IOP) changes and complications after XEN45 implants in medically controlled eyes (MCE) vs. medically uncontrolled eyes (MUE). Methods: A retrospective study, in a tertiary referral hospital, on mild-to-moderate primary open-angle glaucoma (POAG) cases under topical medication, including 32 eyes with IOP &lt; 21 mmHg (MCE group) and 30 eyes with IOP \u2265 21 mmHg (MUE group). The success criteria using Kaplan\u2013Meier analysis was IOP &lt; 21 mmHg without medications (complete success) or fewer drugs than preoperatively (qualified success) at the last visit, without new surgery or unresolved hypotony. Results: No significant preoperative differences were found between the groups. The mean IOP was 15.6 \u00b1 3.8 mmHg in MCE and 15.1 \u00b1 4.1 mmHg in the MUE group (p &gt; 0.05; Mann\u2013Whitney test) at the end of the follow-up (mean of 26.1 \u00b1 15.6 months and 28.3 \u00b1 15.3 months, respectively) (p = 0.414, Mann\u2013Whitney Test). The device caused a significant IOP reduction at 24 h in both groups. Thereafter, the MCE group significantly tended to increase IOP, recovering baseline values at 1 month and maintaining them until the end of the follow-up. In contrast, in the MUE group, the IOP values tended to be similar after the first reduction. No relevant complications and no significant differences between the groups in the survival analysis were found. Conclusions: XEN45 provided stable IOP control in both the MCE and MUE group without important complications in the medium term. The IOP increasing in the MCE group, after a prior decrease, led to restored baseline values 1 month after surgery. The homeostatic mechanism that causes the rise in the IOP to baseline values and its relationship with failure cases remains to be clarified.<\/jats:p>","DOI":"10.3390\/jcm13123406","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T12:11:00Z","timestamp":1718107860000},"page":"3406","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["XEN45 Implant in Medically Controlled vs. Uncontrolled Eyes\u2014Differential IOP Changes in Real-Life Conditions"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4666-1288","authenticated-orcid":false,"given":"Gemma","family":"Julio","sequence":"first","affiliation":[{"name":"Centro de Oftalmolog\u00eda Barraquer, 08021 Barcelona, Spain"},{"name":"Institut Universitari Barraquer, Universitat Aut\u00f2noma de Catalunya, 08021 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6229-8656","authenticated-orcid":false,"given":"Raquel","family":"Larena","sequence":"additional","affiliation":[{"name":"Centro de Oftalmolog\u00eda Barraquer, 08021 Barcelona, Spain"},{"name":"Institut Universitari Barraquer, Universitat Aut\u00f2noma de Catalunya, 08021 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"M\u00e1rmol","sequence":"additional","affiliation":[{"name":"Centro de Oftalmolog\u00eda Barraquer, 08021 Barcelona, Spain"},{"name":"Institut Universitari Barraquer, Universitat Aut\u00f2noma de Catalunya, 08021 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Soldevila","sequence":"additional","affiliation":[{"name":"Centro de Oftalmolog\u00eda Barraquer, 08021 Barcelona, Spain"},{"name":"Institut Universitari Barraquer, Universitat Aut\u00f2noma de Catalunya, 08021 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Isabel","family":"Canut","sequence":"additional","affiliation":[{"name":"Centro de Oftalmolog\u00eda Barraquer, 08021 Barcelona, Spain"},{"name":"Institut Universitari Barraquer, Universitat Aut\u00f2noma de Catalunya, 08021 Barcelona, Spain"},{"name":"Cl\u00ednica Oftalvist, 08017 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josip","family":"Pavan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Dubrava University Hospital, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael I.","family":"Barraquer","sequence":"additional","affiliation":[{"name":"Centro de Oftalmolog\u00eda Barraquer, 08021 Barcelona, Spain"},{"name":"Institut Universitari Barraquer, Universitat Aut\u00f2noma de Catalunya, 08021 Barcelona, Spain"},{"name":"School of Medicine, Universitat Internacional de Catalunya, 08193 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"ref_1","first-page":"931","article-title":"Ocular Surface Evaluation in Eyes with Chronic Glaucoma on Long Term Topical Antiglaucoma Therapy","volume":"10","author":"Saini","year":"2017","journal-title":"Int. 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