{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T21:50:43Z","timestamp":1768686643468,"version":"3.49.0"},"reference-count":104,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Calcinosis cutis is the deposition of insoluble calcium salts, which may cause inflammation, ulceration, pain, and restricted joint mobility. It rarely develops in damaged tissues (dystrophic subtype), most frequently in autoimmune connective tissue diseases (CTDs), but there is very limited data on the prevalence. Also, therapy remains an unsolved issue. In this study, we aimed to collect data on the prevalence of calcinosis in CTD patients to highlight that it is a considerable problem. Methods: A retrospective study was conducted in our department to assess the epidemiology of dystrophic calcinosis in CTDs between January 2003 and January 2024. Results: A total of 839 CTD patients were identified, of whom 56 had calcinosis (6.67%). The mean age of the calcinosis patients at diagnosis of underlying CTD was 41.16 \u00b1 19.47 years. The mean time interval from the onset of calcinosis was 5.96 \u00b1 8.62 years. Systemic sclerosis was the most common CTD complicated by calcinosis (n = 22). Conclusions: Our results are comparable to those reported previously in the literature. Although calcinosis is rare in the overall population, it is a present and unsolved problem in CTD patients. Therefore, further studies are needed on the factors involved in the development and progression of calcinosis as well as its treatment.<\/jats:p>","DOI":"10.3390\/jcm13123428","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T04:15:27Z","timestamp":1718165727000},"page":"3428","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Calcinosis Prevalence in Autoimmune Connective Tissue Diseases\u2014A Retrospective Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2495-1164","authenticated-orcid":false,"given":"Lili","family":"R\u00f3bert","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, H-1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kriszti\u00e1n","family":"N\u00e9meth","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, H-1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rta","family":"Marschalk\u00f3","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, H-1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Holl\u00f3","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, H-1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernadett","family":"Hidv\u00e9gi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, H-1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.semarthrit.2005.01.016","article-title":"Calcinosis in rheumatic diseases","volume":"34","author":"Boulman","year":"2005","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11926-020-00951-2","article-title":"Calcinosis in Systemic Sclerosis: Updates in Pathophysiology, Evaluation, and Treatment","volume":"22","author":"Richardson","year":"2020","journal-title":"Curr. Rheumatol. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Mormile, I., Mosella, F., Turco, P., Napolitano, F., de Paulis, A., and Rossi, F.W. (2023). Calcinosis Cutis and Calciphylaxis in Autoimmune Connective Tissue Diseases. Vaccines, 11.","DOI":"10.3390\/vaccines11050898"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/0190-9622(95)91803-5","article-title":"Calcifying disorders of the skin","volume":"33","author":"Walsh","year":"1995","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1529-8019.2012.01492.x","article-title":"Calcinosis cutis in autoimmune connective tissue diseases","volume":"25","author":"Gutierrez","year":"2012","journal-title":"Dermatol. Ther."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1001\/archderm.1990.01670320084015","article-title":"Extensive calcinosis cutis with systemic lupus erythematosus","volume":"126","author":"Rothe","year":"1990","journal-title":"Arch. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1080\/000155501317208516","article-title":"Extensive calcinosis cutis in association with systemic lupus erythematosus","volume":"81","author":"Bhatia","year":"2001","journal-title":"Acta Derm. Venereol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/BOR.0b013e32834ff5cd","article-title":"Soft tissue and subcutaneous calcification in connective tissue diseases","volume":"24","author":"Chander","year":"2012","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.semarthrit.2011.11.007","article-title":"Treatment of systemic sclerosis-associated calcinosis: A case report of rituximab-induced regression of CREST-related calcinosis and review of the literature","volume":"41","author":"Daoussis","year":"2012","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1067\/mpd.2001.112473","article-title":"New insight into calcinosis of juvenile dermatomyositis: A study of composition and treatment","volume":"138","author":"Mukamel","year":"2001","journal-title":"J. Pediatr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1186\/s13075-014-0480-6","article-title":"Potential role of the lectin pathway of complement in the pathogenesis and disease manifestations of systemic sclerosis: A case-control and cohort study","volume":"16","author":"Osthoff","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3109\/03009742.2015.1127412","article-title":"Calcinosis preferentially affects the thumb compared to other fingers in patients with systemic sclerosis","volume":"45","author":"Gauhar","year":"2016","journal-title":"Scand. J. Rheumatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00281-015-0505-5","article-title":"Vasculopathy in scleroderma","volume":"37","author":"Asano","year":"2015","journal-title":"Semin. Immunopathol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Cantatore, F.P., Maruotti, N., Corrado, A., and Ribatti, D. (2017). Angiogenesis Dysregulation in the Pathogenesis of Systemic Sclerosis. BioMed Res. Int., 2017.","DOI":"10.1155\/2017\/5345673"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.humpath.2005.10.007","article-title":"The differential expression of VEGF, VEGFR-2, and GLUT-1 proteins in disease subtypes of systemic sclerosis","volume":"37","author":"Davies","year":"2006","journal-title":"Hum. Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1093\/rheumatology\/kep151","article-title":"Expression of advanced glycation end products and their receptor in skin from patients with systemic sclerosis with and without calcinosis","volume":"48","author":"Davies","year":"2009","journal-title":"Rheumatology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.lpm.2018.02.005","article-title":"Extensive calcinosis cutis in a patient with systemic lupus erythematosus: An exceptional complication","volume":"47","author":"Ammouri","year":"2018","journal-title":"Presse Medicale"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1093\/rheumatology\/keaa131","article-title":"A pilot study of cutaneous oxygenation and perfusion in systemic sclerosis-related digital calcinosis","volume":"59","author":"Manning","year":"2020","journal-title":"Rheumatology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/acr.24327","article-title":"Ultrasound Detection of Calcinosis and Association With Ulnar Artery Occlusion in Patients With Systemic Sclerosis","volume":"73","author":"Fairchild","year":"2021","journal-title":"Arthritis Care Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1136\/ard.2010.134304","article-title":"Predictive factors of hand radiographic lesions in systemic sclerosis: A prospective study","volume":"70","author":"Avouac","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1093\/rheumatology\/kes214","article-title":"Acro-osteolysis in systemic sclerosis is associated with digital ischaemia and severe calcinosis","volume":"51","author":"Johnstone","year":"2012","journal-title":"Rheumatology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.semarthrit.2010.06.008","article-title":"Hand radiological damage in systemic sclerosis: Comparison with a control group and clinical and functional correlations","volume":"40","author":"Koutaissoff","year":"2011","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/art.39424","article-title":"Association of Acroosteolysis with Enhanced Osteoclastogenesis and Higher Blood Levels of Vascular Endothelial Growth Factor in Systemic Sclerosis","volume":"68","author":"Park","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"ref_24","first-page":"326","article-title":"The value of ultrasound in the diagnosis of limited scleroderma-a case report","volume":"15","year":"2015","journal-title":"J. Ultrason."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/med.1010","article-title":"Arterial calcification: A review of mechanisms, animal models, and the prospects for therapy","volume":"21","author":"Wallin","year":"2001","journal-title":"Med. Res. Rev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1161\/hq1201.100229","article-title":"Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques","volume":"21","author":"Dhore","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/jcb.10669","article-title":"Matrix GLA protein and BMP-2 regulate osteoinduction in calcifying vascular cells","volume":"90","author":"Zebboudj","year":"2003","journal-title":"J. Cell. Biochem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1006\/bbrc.2001.5996","article-title":"Matrix Gla protein accumulates at the border of regions of calcification and normal tissue in the media of the arterial vessel wall","volume":"289","author":"Spronk","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.3899\/jrheum.100627","article-title":"Role of fetuin-A in systemic sclerosis-associated calcinosis","volume":"37","author":"Belloli","year":"2010","journal-title":"J. Rheumatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.3899\/jrheum.080192","article-title":"Circulating osteoprotegerin and soluble RANK ligand in systemic sclerosis","volume":"35","author":"Dovio","year":"2008","journal-title":"J. Rheumatol."},{"key":"ref_31","first-page":"259","article-title":"Role of fibroblast growth factor-23 in calcinosis in women with systemic sclerosis","volume":"45","author":"Martin","year":"2020","journal-title":"Acta Reumatol. Port."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/23971983211053245","article-title":"Subcutaneous calcinosis: Is it different between systemic sclerosis and dermatomyositis?","volume":"7","author":"Valenzuela","year":"2022","journal-title":"J. Scleroderma Relat. Disord."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1111\/bjd.12785","article-title":"Plain radiography is effective for the detection of calcinosis cutis occurring in association with autoimmune connective tissue disease","volume":"170","author":"Shahi","year":"2014","journal-title":"Br. J. Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1148\/radiol.13121994","article-title":"Hand and wrist involvement in systemic sclerosis: US features","volume":"269","author":"Freire","year":"2013","journal-title":"Radiology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.crad.2012.07.009","article-title":"MDCT imaging of calcinosis in systemic sclerosis","volume":"68","author":"Freire","year":"2013","journal-title":"Clin. Radiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1007\/s10067-015-2998-7","article-title":"Use of dual-energy computed tomography for the evaluation of calcinosis in patients with systemic sclerosis","volume":"34","author":"Hsu","year":"2015","journal-title":"Clin. Rheumatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1002\/1529-0131(200008)43:8<1866::AID-ANR24>3.0.CO;2-6","article-title":"Magnetic resonance imaging detection of occult skin and subcutaneous abnormalities in juvenile dermatomyositis. Implications for diagnosis and therapy","volume":"43","author":"Kimball","year":"2000","journal-title":"Arthritis Rheum."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3899\/jrheum.140773","article-title":"Dual-energy computed tomography for the evaluation of calcinosis in systemic sclerosis","volume":"42","author":"Hsu","year":"2015","journal-title":"J. Rheumatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1097\/BOR.0000000000000539","article-title":"Calcinosis in scleroderma","volume":"30","author":"Valenzuela","year":"2018","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jaad.2019.07.006","article-title":"Treatment of calcinosis cutis in systemic sclerosis and dermatomyositis: A review of the literature","volume":"82","author":"Traineau","year":"2020","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_41","first-page":"3536","article-title":"Calcinosis universalis complicating juvenile dermatomyositis: Resolution during probenecid therapy","volume":"82","author":"Eddy","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_42","first-page":"1691","article-title":"Efficacy of probenecid for a patient with juvenile dermatomyositis complicated with calcinosis","volume":"33","author":"Nakamura","year":"2006","journal-title":"J. Rheumatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3346\/jkms.1999.14.5.589","article-title":"Large subcutaneous calcification in systemic lupus erythematosus: Treatment with oral aluminum hydroxide administration followed by surgical excision","volume":"14","author":"Park","year":"1999","journal-title":"J. Korean Med. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1016\/j.jaad.2009.11.016","article-title":"Subcutaneous morphea with dystrophic calcification with response to ceftriaxone treatment","volume":"63","author":"Reiter","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1136\/ard.2003.014431","article-title":"Low dose warfarin treatment for calcinosis in patients with systemic sclerosis","volume":"63","author":"Cukierman","year":"2004","journal-title":"Ann. Rheum. Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1546-0096-8-6","article-title":"Efficacy of thalidomide in a girl with inflammatory calcinosis, a severe complication of juvenile dermatomyositis","volume":"8","author":"Miyamae","year":"2010","journal-title":"Pediatr. Rheumatol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"R\u00f3bert, L., B\u00e1nv\u00f6lgyi, A., L\u0151rincz, K., Holl\u00f3, P., and Hidv\u00e9gi, B. (2023). Systemic Sodium Thiosulfate as an Adjunct Treatment in Calcinosis: A Retrospective Study. J. Clin. Med., 12.","DOI":"10.3390\/jcm12247741"},{"key":"ref_48","first-page":"e26","article-title":"Localized calcinosis in juvenile dermatomyositis: Successful treatment with intralesional corticosteroids injection","volume":"13","author":"Alsonbul","year":"2010","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1001\/archderm.1982.01650170080035","article-title":"Cutaneous calcinosis of scleroderma. Successful treatment with intralesional adrenal steroids","volume":"118","author":"Hazen","year":"1982","journal-title":"Arch. Dermatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1001\/archdermatol.2011.2052","article-title":"Calcinosis cutis occurring in association with autoimmune connective tissue disease: The Mayo Clinic experience with 78 patients, 1996\u20132009","volume":"148","author":"Balin","year":"2012","journal-title":"Arch. Dermatol."},{"key":"ref_51","first-page":"135","article-title":"Effectiveness of the treatment with intravenous pamidronate in calcinosis in juvenile dermatomyositis","volume":"28","year":"2010","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1001\/archderm.1975.01630150077009","article-title":"Disodium etidronate therapy for dystrophic cutaneous calcification","volume":"111","author":"Rabens","year":"1975","journal-title":"Arch. Dermatol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Rauch, L., Hein, R., Biedermann, T., Eyerich, K., and Lauffer, F. (2021). Bisphosphonates for the Treatment of Calcinosis Cutis-A Retrospective Single-Center Study. Biomedicines, 9.","DOI":"10.3390\/biomedicines9111698"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.jaad.2008.09.051","article-title":"Calcinosis cutis associated with amyopathic dermatomyositis: Response to intravenous immunoglobulin","volume":"60","author":"Guillermo","year":"2009","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1001\/archderm.144.5.585","article-title":"Response of dystrophic calcification to intravenous immunoglobulin","volume":"144","author":"Schanz","year":"2008","journal-title":"Arch. Dermatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jbspin.2012.07.001","article-title":"Calcinosis universalis complicating juvenile dermatomyositis: Improvement after intravenous immunoglobulin therapy","volume":"80","author":"Touimy","year":"2013","journal-title":"Jt. Bone Spine"},{"key":"ref_57","first-page":"527","article-title":"Colchicine suppression of local inflammation due to calcinosis in dermatomyositis and progressive systemic sclerosis","volume":"5","author":"Fuchs","year":"1986","journal-title":"Clin. Rheumatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1136\/ard.62.3.267","article-title":"Treatment of cutaneous calcinosis in limited systemic sclerosis with minocycline","volume":"62","author":"Robertson","year":"2003","journal-title":"Ann. Rheum. Dis."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10067-012-2124-z","article-title":"Rituximab-induced regression of CREST-related calcinosis","volume":"32","author":"Klem","year":"2013","journal-title":"Clin. Rheumatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jaad.2010.08.039","article-title":"Calcinosis cutis: Part II. Treatment options","volume":"65","author":"Reiter","year":"2011","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1365-2133.1996.tb01166.x","article-title":"Digital calcification in systemic sclerosis: Effective treatment with good tissue preservation using the carbon dioxide laser","volume":"135","author":"Bottomley","year":"1996","journal-title":"Br. J. Dermatol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s10067-004-1023-3","article-title":"Electric shock wave lithotripsy (ESWL) as a pain control measure in dermatomyositis with calcinosis cutis-old method, new discovery","volume":"24","author":"Chan","year":"2005","journal-title":"Clin. Rheumatol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"S263","DOI":"10.1016\/j.jaad.2005.04.010","article-title":"Treatment of cutaneous calcinosis in CREST syndrome by extracorporeal shock wave lithotripsy","volume":"53","author":"Sparsa","year":"2005","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1093\/rheumatology\/kew313","article-title":"Calcinosis is associated with digital ischaemia in systemic sclerosis-a longitudinal study","volume":"55","author":"Baron","year":"2016","journal-title":"Rheumatology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s10067-016-3412-9","article-title":"Clinical, biochemical, and radiological characterization of the calcinosis in a cohort of Mexican patients with systemic sclerosis","volume":"36","author":"Saavedra","year":"2017","journal-title":"Clin. Rheumatol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e8980","DOI":"10.1097\/MD.0000000000008980","article-title":"Clinical and serological features of systemic sclerosis in a multicenter African American cohort: Analysis of the genome research in African American scleroderma patients clinical database","volume":"96","author":"Morgan","year":"2017","journal-title":"Medicine"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1136\/ard.57.4.252","article-title":"Clinical significance of subcutaneous calcinosis in patients with systemic sclerosis. Does diltiazem induce its regression?","volume":"57","author":"Vayssairat","year":"1998","journal-title":"Ann. Rheum. Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1080\/14397595.2021.1886654","article-title":"Prevalence and clinical association with calcinosis cutis in early systemic sclerosis","volume":"31","author":"Muktabhant","year":"2021","journal-title":"Mod. Rheumatol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"v67","DOI":"10.1093\/rheumatology\/kex200","article-title":"Points to consider for skin ulcers in systemic sclerosis","volume":"56","author":"Galluccio","year":"2017","journal-title":"Rheumatology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1056\/NEJMicm1011692","article-title":"Images in clinical medicine. Calcinosis cutis in systemic sclerosis","volume":"364","author":"Makol","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1136\/ard.50.Suppl_4.854","article-title":"Clinical aspects of systemic sclerosis (scleroderma)","volume":"50","author":"Silver","year":"1991","journal-title":"Ann. Rheum. Dis."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.semarthrit.2020.06.007","article-title":"Calcinosis is associated with ischemic manifestations and increased disability in patients with systemic sclerosis","volume":"50","author":"Valenzuela","year":"2020","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1093\/rheumatology\/kew193","article-title":"Calcinosis in systemic sclerosis: Subsets, distribution and complications","volume":"55","author":"Bartoli","year":"2016","journal-title":"Rheumatology"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"194","DOI":"10.5301\/jsrd.5000211","article-title":"Systemic sclerosis-related calcinosis","volume":"1","author":"Herrick","year":"2016","journal-title":"J. Scleroderma Relat. Disord."},{"key":"ref_75","first-page":"33","article-title":"An Update on the Treatment of the Cutaneous Manifestations of Systemic Sclerosis: The Dermatologist\u2019s Point of View","volume":"5","author":"Vitiello","year":"2012","journal-title":"J. Clin. Aesthetic Dermatol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/acr.22672","article-title":"Late Nailfold Videocapillaroscopy Pattern Associated With Hand Calcinosis and Acro-Osteolysis in Systemic Sclerosis","volume":"68","author":"Morardet","year":"2016","journal-title":"Arthritis Care Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/BOR.0000000000000220","article-title":"Calcinosis: Pathophysiology and management","volume":"27","author":"Valenzuela","year":"2015","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/art.1780270202","article-title":"Clinical and laboratory associations of anticentromere antibody in patients with progressive systemic sclerosis","volume":"27","author":"Steen","year":"1984","journal-title":"Arthritis Rheum."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/1756-185X.12322","article-title":"Clinical and autoantibody profile in systemic sclerosis: Baseline characteristics from a West Malaysian cohort","volume":"18","author":"Sujau","year":"2015","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.jdcr.2020.06.022","article-title":"Novel treatment of calcifications from dermatomyositis with picosecond and carbon dioxide laser","volume":"6","author":"Abrouk","year":"2020","journal-title":"JAAD Case Rep."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/rheumatology\/keaa331","article-title":"Calcinosis cutis universalis in dermatopathic dermatomyositis","volume":"60","author":"Jawad","year":"2021","journal-title":"Rheumatology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2214\/ajr.142.2.397","article-title":"Patterns of calcification in childhood dermatomyositis","volume":"142","author":"Blane","year":"1984","journal-title":"Am. J. Roentgenol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0022-3476(83)80706-9","article-title":"Childhood dermatomyositis: Factors predicting functional outcome and development of dystrophic calcification","volume":"103","author":"Bowyer","year":"1983","journal-title":"J. Pediatr."},{"key":"ref_84","first-page":"303","article-title":"Calcinosis in poly-dermatomyositis: Clinical and laboratory predictors and treatment options","volume":"35","author":"Fredi","year":"2017","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1590\/S0482-50042012000400007","article-title":"High frequency of calcinosis in juvenile dermatomyositis: A risk factor study","volume":"52","author":"Clemente","year":"2012","journal-title":"Rev. Bras. Reumatol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/rheumatology\/kel099","article-title":"The Juvenile Dermatomyositis National Registry and Repository (UK and Ireland)\u2014Clinical characteristics of children recruited within the first 5 yr","volume":"45","author":"McCann","year":"2006","journal-title":"Rheumatology"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1067\/mjd.2002.122196","article-title":"Aggressive management of juvenile dermatomyositis results in improved outcome and decreased incidence of calcinosis","volume":"47","author":"Fisler","year":"2002","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1002\/art.41262","article-title":"Giant Calcinosis in Dermatomyositis and Scleroderma Overlap","volume":"72","author":"Pope","year":"2020","journal-title":"Arthritis Rheumatol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/BOR.0b013e328331927e","article-title":"Juvenile dermatomyositis: Extramuscular manifestations and their management","volume":"21","author":"Lowry","year":"2009","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1001\/jamadermatol.2013.10416","article-title":"Identification of clinical features and autoantibodies associated with calcinosis in dermatomyositis","volume":"150","author":"Valenzuela","year":"2014","journal-title":"JAMA Dermatol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1093\/rheumatology\/keaa618","article-title":"Clinical features, treatments and outcomes of calcinosis in adult patients with dermatomyositis: A single cohort study","volume":"60","author":"Jiang","year":"2021","journal-title":"Rheumatology"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1200\/JCO.2003.09.104","article-title":"Some unusual paraneoplastic syndromes. Case 3. Metastatic pulmonary calcification causing hypoxemia in male breast cancer","volume":"21","author":"Agrawal","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1002\/1097-0142(19810901)48:5<1256::AID-CNCR2820480534>3.0.CO;2-4","article-title":"Osteosarcoma arising in heterotopic ossification of dermatomyositis: Case report and review of the literature","volume":"48","author":"Eckardt","year":"1981","journal-title":"Cancer"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1525-1470.2009.00875.x","article-title":"Lymphoma arising from a calcinotic lesion in a patient with juvenile dermatomyositis","volume":"26","author":"Morris","year":"2009","journal-title":"Pediatr. Dermatol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/j.1346-8138.2010.00894.x","article-title":"Calcinosis cutis in systemic lupus erythematosus: A case report and review of the published work","volume":"37","author":"Kim","year":"2010","journal-title":"J. Dermatol."},{"key":"ref_96","first-page":"1137","article-title":"A Retrospective Study of Calcinosis Cutis in Patients With Systemic Lupus Erythematosus","volume":"21","author":"Tiao","year":"2022","journal-title":"J. Drugs Dermatol. JDD"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2010.08.038","article-title":"Calcinosis cutis: Part I. Diagnostic pathway","volume":"65","author":"Reiter","year":"2011","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_98","first-page":"e8727","article-title":"Dystrophic Calcinosis Cutis in Systemic Lupus Erythematosus","volume":"12","author":"Achebe","year":"2020","journal-title":"Cureus"},{"key":"ref_99","first-page":"55","article-title":"Pharmacological treatment in calcinosis cutis associated with connective-tissue diseases","volume":"52","author":"Dima","year":"2014","journal-title":"Rom. J. Intern. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.kjms.2014.03.009","article-title":"Extensive calcinosis cutis universalis in a patient with systemic lupus erythematosus: 10-year treatment experience","volume":"30","author":"Huang","year":"2014","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1136\/ard.62.7.690","article-title":"Overlap connective tissue disease, pulmonary fibrosis, and extensive subcutaneous calcification","volume":"62","author":"Chan","year":"2003","journal-title":"Ann. Rheum. Dis."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/00124743-199904000-00007","article-title":"Successful use of diltiazem in calcinosis caused by connective tissue disease","volume":"5","author":"Torralba","year":"1999","journal-title":"J. Clin. Rheumatol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1093\/rheumatology\/40.8.947","article-title":"Superficial calcinosis related to bleeding in a patient with undifferentiated connective tissue disease and primary biliary cirrhosis","volume":"40","author":"Palazzi","year":"2001","journal-title":"Rheumatology"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2169\/internalmedicine.37.421","article-title":"Mixed connective tissue disease with severe pulmonary hypertension and extensive subcutaneous calcification","volume":"37","author":"Itoh","year":"1998","journal-title":"Intern. Med."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/12\/3428\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:57:10Z","timestamp":1760108230000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/12\/3428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,12]]},"references-count":104,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["jcm13123428"],"URL":"https:\/\/doi.org\/10.3390\/jcm13123428","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,12]]}}}