{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:09:58Z","timestamp":1790140198058,"version":"4.0.1"},"reference-count":62,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: To systematically review and meta-analyze the immunologic aspects and outcomes of various endothelial keratoplasty (EK) techniques, specifically comparing Descemet\u2019s Stripping Automated Endothelial Keratoplasty (DSAEK), Ultra-Thin Descemet\u2019s Stripping Automated Endothelial Keratoplasty (UT-DSAEK), and Descemet\u2019s Membrane Endothelial Keratoplasty (DMEK). Methods: Systematic review and meta-analysis. Main outcomes were the proportion of patients achieving a best spectacle-corrected visual acuity (BSCVA) of 20\/20 at 6 months after keratoplasty, rejection rate one year after surgery, BSCVA at last follow up, and postoperative immunomodulating regimen. Results: A higher proportion of DMEK patients achieved a BSCVA of 20\/20 after 6 months. UT-DSAEK and DMEK showed similar rejection rates with a lower risk of re-bubbling for UT-DSAEK (4% vs. 20%). Conclusions: DMEK showed faster visual recovery than UT-DSAEK but a similar rejection rate and long-term visual acuity. One-year postoperative slow tapering steroid regimen has a positive but not (yet) significant effect on rejection risk and visual outcomes.<\/jats:p>","DOI":"10.3390\/jcm13123431","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T06:47:30Z","timestamp":1718174850000},"page":"3431","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Functional and Immunologic Point of View on Corneal Endothelial Transplantation: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9442-5741","authenticated-orcid":false,"given":"Sara","family":"Spelta","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University Campus Bio-Medico, 00128 Rome, Italy"},{"name":"Fondazione Policlinico Campus Bio-Medico, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9375-6071","authenticated-orcid":false,"given":"Alessandra","family":"Micera","sequence":"additional","affiliation":[{"name":"Research and Development Laboratory for Biochemical, Molecular and Cellular Applications in Ophthalmological Sciences, IRCCS\u2013Fondazione Bietti, 00184 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5624-8775","authenticated-orcid":false,"given":"Daniele","family":"Gaudenzi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Campus Bio-Medico, 00128 Rome, Italy"},{"name":"Fondazione Policlinico Campus Bio-Medico, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Niutta","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Campus Bio-Medico, 00128 Rome, Italy"},{"name":"Fondazione Policlinico Campus Bio-Medico, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7721-4694","authenticated-orcid":false,"given":"Pier Luigi","family":"Surico","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Campus Bio-Medico, 00128 Rome, Italy"},{"name":"Fondazione Policlinico Campus Bio-Medico, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"De Vincentis","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Campus Bio-Medico, 00128 Rome, Italy"},{"name":"Internal Medicine, University Campus Bio-Medico, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Coassin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Campus Bio-Medico, 00128 Rome, Italy"},{"name":"Fondazione Policlinico Campus Bio-Medico, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Di Zazzo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Campus Bio-Medico, 00128 Rome, Italy"},{"name":"Fondazione Policlinico Campus Bio-Medico, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/ni1328","article-title":"See no evil, hear no evil, do no evil: The lessons of immune privilege","volume":"7","author":"Niederkorn","year":"2006","journal-title":"Nat. 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