{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:43:53Z","timestamp":1760111033304,"version":"build-2065373602"},"reference-count":42,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health","award":["RC 17\/23"],"award-info":[{"award-number":["RC 17\/23"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The authors present the case of a young boy who experienced progressive unilateral hearing loss initially believed to be unrelated to any other medical condition. Methods: The patient received a thorough evaluation, which included a comprehensive battery of audiological tests, a CT scan, and a gadolinium-enhanced MRI. Results: A repeated imaging investigation revealed the presence of a mass that mimicked a vestibular schwannoma (VS), but despite this, the boy was ultimately diagnosed with cerebral manifestations of B-cell acute lymphoblastic leukemia (B-ALL). Conclusions: Cerebral lesions originating from the internal auditory canal are rare in cases of B-ALL. In this case, the initial signs and symptoms of the disease were solely related to the audiovestibular system, making the diagnostic process particularly complicated. Unilateral hearing loss cases may indicate the presence of potentially life-threatening conditions, even if the hearing loss appears to be clinically non-syndromic. For these reasons, unilateral hearing losses necessitate a comprehensive interdisciplinary diagnostic approach from the very start of auditory manifestation and, in particular, if the hearing impairment demonstrates threshold progression.<\/jats:p>","DOI":"10.3390\/jcm13123483","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T08:02:26Z","timestamp":1718352146000},"page":"3483","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case Report of Malignant Cerebellopontine Angle Lesion Highlighting the Interdisciplinary Diagnostic Challenge in the Case of Unilateral Progressive Hearing Loss"],"prefix":"10.3390","volume":"13","author":[{"given":"Riccardo","family":"Marzolino","sequence":"first","affiliation":[{"name":"Otorhinolaryngology and Audiology Unit, Institute for Maternal and Child Health\u2014IRCCS \u201cBurlo Garofolo\u201d, Via dell\u2019Istria 63, 34137 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Castro","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology and Audiology Unit, Institute for Maternal and Child Health\u2014IRCCS \u201cBurlo Garofolo\u201d, Via dell\u2019Istria 63, 34137 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4875-1201","authenticated-orcid":false,"given":"Valeria","family":"Gambacorta","sequence":"additional","affiliation":[{"name":"Section of Otorhinolaryngology, Department of Medicine and Surgery, University of Perugia, 06129 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Tonon","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology and Audiology Unit, Institute for Maternal and Child Health\u2014IRCCS \u201cBurlo Garofolo\u201d, Via dell\u2019Istria 63, 34137 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Cattaruzzi","sequence":"additional","affiliation":[{"name":"Pediatric Radiology Department, Institute for Maternal and Child Health IRCCS \u201cBurlo Garofolo,\u201d 34137 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7465-1066","authenticated-orcid":false,"given":"Eva","family":"Orzan","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology and Audiology Unit, Institute for Maternal and Child Health\u2014IRCCS \u201cBurlo Garofolo\u201d, Via dell\u2019Istria 63, 34137 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/00003446-199810000-00001","article-title":"Children with minimal sensorineural hearing loss: Prevalence, educational performance, and functional status","volume":"19","author":"Bess","year":"1998","journal-title":"Ear Hear."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"d7962","DOI":"10.1136\/bmj.d7962","article-title":"Vitamin A supplementation in preschool children and risk of hearing loss as adolescents and young adults in rural Nepal: Randomised trial cohort follow-up study","volume":"344","author":"Schmitz","year":"2012","journal-title":"BMJ"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1002\/lary.23889","article-title":"Significance of unilateral enlarged vestibular aqueduct","volume":"123","author":"Greinwald","year":"2013","journal-title":"Laryngoscope"},{"key":"ref_4","unstructured":"(2013, June 12). 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