{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T03:21:47Z","timestamp":1787196107875,"version":"build-2736575974"},"reference-count":74,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T00:00:00Z","timestamp":1718496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Lublin","award":["DS 377"],"award-info":[{"award-number":["DS 377"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The sulfide\u2013hydrogen sulfide brine balneotherapy (HSBB), including a combination of dissolved hydrogen sulfide (H2S) gas, inorganic sulfur ions (S2\u2212), and hydrosulfide ions (HS\u2212), is one of the most important and most effective forms of spa treatment in patients with osteoarticular disorders (OADs). Some cardiovascular diseases (CVDs) are often considered to be contraindications to HSBB since the presence of thiol groups may lead to an increased quantity of reactive oxygen species (ROS), which damage the vascular endothelium, and endothelial dysfunction is considered to be the main cause of atherosclerosis. However, there are a number of literature reports suggesting this theory to be false. H2S is a member of the endogenous gaseous transmitter family and, since it is a relatively recent addition, it has the least well-known biological properties. H2S\u2013NO interactions play an important role in oxidative stress in CVDs. The general objective of this study was to assess the cardiovascular safety of HSBB and analyze the effect of HSBB on selected cardiovascular risk markers. Methods: A total of 100 patients at the age of 76.3 (\u00b17.5) years from the W\u0142\u00f3kniarz Sanatorium in Busko-Zdr\u00f3j were initially included in the study. The following parameters were assessed: age, sex, height, body weight, body surface area (BSA), body mass index (BMI), systolic (SBP) and diastolic blood pressure (DBP), heart rate, the diagnosis of OAD that was the indication for balneotherapy, creatinine (CREAT), glomerular filtration rate (GFR), lipid panel, C-reactive protein (CRP), uric acid (UA), and fibrinogen (FIBR) and cardiovascular markers: (cardiac troponin T (cTnT), N-terminal pro-B-type natriuretic peptide (NT-proBNP). Results: A significant decrease in DBP and a trend towards SBP reduction were observed over the course of the study. A significant decrease was observed in CRP levels decreasing from 2.7 (\u00b13.6) mg\/L to 2.06 (\u00b11.91) mg\/L, whereas FIBR rose significantly from 2.95 (\u00b10.59) g\/L to 3.23 (\u00b11.23) g\/L. LDL-C levels decreased slightly, statistically significant, from 129.36 (\u00b140.67) mg\/dL to 123.74 (\u00b136.14) mg\/dL. HSBB did not affect the levels of evaluated cardiovascular biomarkers, namely NT-proBNP (137.41 (\u00b1176.52) pg\/mL vs. 142.89 (\u00b1182.82) pg\/mL; p = 0.477) and cTnT (9.64 (\u00b14.13) vs. 9.65 (\u00b13.91) ng\/L; p = 0.948). A multiple regression analysis of pre-balneotherapy and post-balneotherapy values showed cTnT levels to be independently correlated only with CREAT levels and GFR values. None of the assessed parameters independently correlated with the NT-proBNP level. Conclusions: HSBB resulted in a statistically significant improvement in a subclinical pro-inflammatory state. HSBB has a beneficial effect in modifying key cardiovascular risk factors by reducing LDL-C levels and DBP values. HSBB has a neutral effect on cardiovascular ischemia\/injury. Despite slightly elevated baseline levels of the biochemical marker of HF (NT-proBNP), HSBB causes no further increase in this marker. The use of HSBB in patients with OAD has either a neutral effect or a potentially beneficial effect on the cardiovascular system, which may constitute grounds for further studies to verify the current cardiovascular contraindications for this form of therapy.<\/jats:p>","DOI":"10.3390\/jcm13123526","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T06:29:43Z","timestamp":1718605783000},"page":"3526","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Influence of Balneotherapy Using Salty Sulfide\u2013Hydrogen Sulfide Water on Selected Markers of the Cardiovascular System: A Prospective Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9808-8853","authenticated-orcid":false,"given":"Tomasz","family":"Zapolski","sequence":"first","affiliation":[{"name":"Department of Cardiology, Medical University of Lublin, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Kornecki","sequence":"additional","affiliation":[{"name":"Sanatorium \u201cW\u0142\u00f3kniarz\u201d, 28-100 Busko Zdr\u00f3j, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8194-1723","authenticated-orcid":false,"given":"Andrzej","family":"Jaroszy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Family Medicine, Collegium Medicum, Jan Kochanowski University in Kielce, 25-369 Kielce, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1161\/CIRCULATIONAHA.106.676890","article-title":"Subendothelial lipoprotein retention as the initiating process in atherosclerosis: Update and therapeutic implications","volume":"116","author":"Tabas","year":"2007","journal-title":"Circulation"},{"key":"ref_2","first-page":"167","article-title":"Evaluation of comprehensive spa treatment of osteoarthritis of the knee at the \u201eW\u0142\u00f3kniarz\u201d Sanatorium in Busko-Zdr\u00f3j","volume":"29","author":"Legwant","year":"2013","journal-title":"Stud. 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