{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T02:38:57Z","timestamp":1783823937174,"version":"3.55.0"},"reference-count":46,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: In vitro fertilization (IVF) has the potential to give babies to millions more people globally, yet it continues to be underutilized. We established a globally applicable and locally adaptable IVF prognostics report and framework to support patient\u2013provider counseling and enable validated, data-driven treatment decisions. This study investigates the IVF utilization rates associated with the usage of machine learning, center-specific (MLCS) prognostic reports (the Univfy\u00ae report) in provider-patient pre-treatment and IVF counseling. Methods: We used a retrospective cohort comprising 24,238 patients with new patient visits (NPV) from 2016 to 2022 across seven fertility centers in 17 locations in seven US states and Ontario, Canada. We tested the association of Univfy report usage and first intra-uterine insemination (IUI) and\/or first IVF usage (a.k.a. conversion) within 180 days, 360 days, and \u201cEver\u201d of NPV as primary outcomes. Results: Univfy report usage was associated with higher direct IVF conversion (without prior IUI), with odds ratios (OR) 3.13 (95% CI 2.83, 3.46), 2.89 (95% CI 2.63, 3.17), and 2.04 (95% CI 1.90, 2.20) and total IVF conversion (with or without prior IUI), OR 3.41 (95% CI 3.09, 3.75), 3.81 (95% CI 3.49, 4.16), and 2.78 (95% CI 2.59, 2.98) in 180-day, 360-day, and Ever analyses, respectively; p &lt; 0.05. Among patients with Univfy report usage, after accounting for center as a factor, older age was a small yet independent predictor of IVF conversion. Conclusions: Usage of a patient-centric, MLCS-based prognostics report was associated with increased IVF conversion among new fertility patients. Further research to study factors influencing treatment decision making and real-world optimization of patient-centric workflows utilizing the MLCS reports is warranted.<\/jats:p>","DOI":"10.3390\/jcm13123560","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T07:33:20Z","timestamp":1718696000000},"page":"3560","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Improving IVF Utilization with Patient-Centric Artificial Intelligence-Machine Learning (AI\/ML): A Retrospective Multicenter Experience"],"prefix":"10.3390","volume":"13","author":[{"given":"Mylene W. M.","family":"Yao","sequence":"first","affiliation":[{"name":"Department of R&D, Univfy Inc., 117 Main Street, #139, Los Altos, CA 94022, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4771-1489","authenticated-orcid":false,"given":"Elizabeth T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of R&D, Univfy Inc., 117 Main Street, #139, Los Altos, CA 94022, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew G.","family":"Retzloff","sequence":"additional","affiliation":[{"name":"Fertility Center of San Antonio, San Antonio, TX 78229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura April","family":"Gago","sequence":"additional","affiliation":[{"name":"Gago Center for Fertility, Brighton, MI 48114, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susannah","family":"Copland","sequence":"additional","affiliation":[{"name":"Atlantic Reproductive Medicine, Raleigh, NC 27617, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Nichols","sequence":"additional","affiliation":[{"name":"Piedmont Reproductive Endocrinology Group, Greenville, SC 29615, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0671-9548","authenticated-orcid":false,"given":"John F.","family":"Payne","sequence":"additional","affiliation":[{"name":"Piedmont Reproductive Endocrinology Group, Greenville, SC 29615, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Opsahl","sequence":"additional","affiliation":[{"name":"Poma Fertility, Kirkland, WA 98034, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Cadesky","sequence":"additional","affiliation":[{"name":"TRIO Fertility Partners, Toronto, ON M5G 2K4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Meriano","sequence":"additional","affiliation":[{"name":"TRIO Fertility Partners, Toronto, ON M5G 2K4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry W.","family":"Donesky","sequence":"additional","affiliation":[{"name":"My Fertility Center, Chattanooga, TN 37421, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Joseph","family":"Bird","sequence":"additional","affiliation":[{"name":"My Fertility Center, Chattanooga, TN 37421, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Peavey","sequence":"additional","affiliation":[{"name":"Atlantic Reproductive Medicine, Raleigh, NC 27617, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Beesley","sequence":"additional","affiliation":[{"name":"Poma Fertility, Kirkland, WA 98034, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Neal","sequence":"additional","affiliation":[{"name":"Fertility Center of San Antonio, San Antonio, TX 78229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Joseph S.","family":"Bird","sequence":"additional","affiliation":[{"name":"My Fertility Center, Chattanooga, TN 37421, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Swanson","sequence":"additional","affiliation":[{"name":"Department of R&D, Univfy Inc., 117 Main Street, #139, Los Altos, CA 94022, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of R&D, Univfy Inc., 117 Main Street, #139, Los Altos, CA 94022, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Walmer","sequence":"additional","affiliation":[{"name":"Atlantic Reproductive Medicine, Raleigh, NC 27617, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"ref_1","unstructured":"European Society of Human Reproduction and Embryology (ESHRE), 2022 (2024, April 29). 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