{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T02:36:24Z","timestamp":1786502184540,"version":"build-2736575974"},"reference-count":38,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T00:00:00Z","timestamp":1719100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health\u2013Ricerca Corrente"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objectives: This overview of Cochrane Systematic Reviews (CSRs) reports on current evidence and its certainty of the effectiveness of interventions for the rehabilitation of people with ischemic heart disease (IHD), included in the World Health Organization Rehabilitation Programme Package of Interventions for Rehabilitation. Methods: We included all the CSRs relevant to people with IHD. We used a mapping synthesis to group outcomes and comparisons of included CSRs, indicating the effectiveness of interventions for rehabilitation and the certainty of evidence. Results: The evidence map included a total of 13 CSRs. The effect of the interventions varied across comparisons, and the certainty of evidence was inconsistent, ranging from high to very low. We found the best evidence for exercise-based cardiac rehabilitation in the reduction of fatal and non-fatal myocardial infarction and all-cause hospital admission up to 12 months follow-up. Also, combined interventions (work-directed interventions, physical conditioning interventions, and psychological interventions) reduce the days needed for returning to work. Conclusions: The current effect and certainty of evidence for several comparisons investigated support the role of exercise-based cardiac rehabilitation in the management of people with IHD, specifically reducing the risk of fatal and non-fatal myocardial infarction and hospitalisation. However, our findings highlight the lack of high-certainty evidence about hard endpoints, particularly total mortality. Future research should prioritise these primary endpoints to enhance the credibility of cardiac rehabilitation.<\/jats:p>","DOI":"10.3390\/jcm13133662","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T06:59:58Z","timestamp":1719212398000},"page":"3662","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Overview of Cochrane Systematic Reviews on Interventions for Rehabilitation in People with Ischemic Heart Disease: A Mapping Synthesis"],"prefix":"10.3390","volume":"13","author":[{"given":"Matteo Johann","family":"Del Furia","sequence":"first","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy"},{"name":"Department of Mental and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy"},{"name":"IRCCS Istituto Ortopedico Galeazzi, 20157 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Arienti","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Research Center, Department of Biomedical Sciences, Humanitas University, Piave Emanuele, 20090 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Cattadori","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy"},{"name":"IRCCS MultiMedica, 20138 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6538-7401","authenticated-orcid":false,"given":"Silvia","family":"Di Marco","sequence":"additional","affiliation":[{"name":"IRCCS MultiMedica, 20138 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8500-7751","authenticated-orcid":false,"given":"Carlotte","family":"Kiekens","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Ortopedico Galeazzi, 20157 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.23736\/S1973-9087.17.04746-3","article-title":"The World Health Organization \u201cRehabilitation 2030: A call for action\u201d","volume":"53","author":"Gimigliano","year":"2017","journal-title":"Eur. J. Phys. Rehabil. Med."},{"key":"ref_2","unstructured":"W.H.O. (2024, February 21). 3rd Global Rehabilitation 2030 Meeting and Launch of the World Rehabilitation Alliance. Available online: https:\/\/www.who.int\/news-room\/events\/detail\/2023\/07\/10\/default-calendar\/3rd-global-rehabilitation-2030-meeting."},{"key":"ref_3","unstructured":"(2019). Global, regional, and national burden of neurological disorders, 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol., 18, 459\u2013480."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1016\/j.apmr.2019.06.002","article-title":"Toward Strengthening Rehabilitation in Health Systems: Methods Used to Develop a WHO Package of Rehabilitation Interventions","volume":"100","author":"Rauch","year":"2019","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_5","unstructured":"W.H.O. (2024, February 21). The Top 10 Causes of Death. Fact Sheet No. 310. Available online: http:\/\/www.who.int\/mediacentre\/factsheets\/fs310\/en\/."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1093\/eurheartj\/ehi733","article-title":"Economic burden of cardiovascular diseases in the enlarged European Union","volume":"27","author":"Leal","year":"2006","journal-title":"Eur. Heart J."},{"key":"ref_8","unstructured":"National institute for Health and Clinical Excellence (2024, February 21). QS99: Secondary Prevention after a Myocardial Infarction (Full Guideline). National Clinical Guidelines Centre, London. Available online: https:\/\/www.nice.org.uk\/guidance\/qs99."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1093\/eurheartj\/ehad191","article-title":"2023 ESC Guidelines for the management of acute coronary syndromes: Developed by the task force on the management of acute coronary syndromes of the European Society of Cardiology (ESC)","volume":"44","author":"Byrne","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1161\/CIR.0000000000001168","article-title":"2023 AHA\/ACC\/ACCP\/ASPC\/NLA\/PCNA Guideline for the Management of Patients With Chronic Coronary Disease: A Report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines","volume":"148","author":"Virani","year":"2023","journal-title":"Circulation"},{"key":"ref_11","first-page":"Ed000142","article-title":"Updated guidance for trusted systematic reviews: A new edition of the Cochrane Handbook for Systematic Reviews of Interventions","volume":"10","author":"Cumpston","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1111\/j.1365-2753.2008.01112.x","article-title":"Evidence mapping: Illustrating an emerging methodology to improve evidence-based practice in youth mental health","volume":"16","author":"Hetrick","year":"2010","journal-title":"J. Eval. Clin. Pract."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1016\/j.apmr.2019.01.021","article-title":"One in 11 Cochrane Reviews Are on Rehabilitation Interventions, According to Pragmatic Inclusion Criteria Developed by Cochrane Rehabilitation","volume":"100","author":"Levack","year":"2019","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jclinepi.2021.03.001","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"134","author":"Page","year":"2021","journal-title":"J. Clin. Epidemiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"478","DOI":"10.23736\/S1973-9087.21.07075-1","article-title":"Cochrane collaborates with the World Health Organization to establish a Package of Rehabilitation Interventions based on the best available evidence","volume":"57","author":"Negrini","year":"2021","journal-title":"Eur. J. Phys. Rehabil. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"j4008","DOI":"10.1136\/bmj.j4008","article-title":"AMSTAR 2: A critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both","volume":"358","author":"Shea","year":"2017","journal-title":"BMJ"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: An emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jclinepi.2010.04.026","article-title":"GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables","volume":"64","author":"Guyatt","year":"2011","journal-title":"J. Clin. Epidemiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13643-016-0204-x","article-title":"What is an evidence map? A systematic review of published evidence maps and their definitions, methods, and products","volume":"5","author":"Hempel","year":"2016","journal-title":"Syst. Rev."},{"key":"ref_20","first-page":"Cd008895","article-title":"Patient education in the management of coronary heart disease","volume":"6","author":"Anderson","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_21","first-page":"Cd006577","article-title":"Music for stress and anxiety reduction in coronary heart disease patients","volume":"2013","author":"Bradt","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_22","first-page":"Cd009386","article-title":"Internet-based interventions for the secondary prevention of coronary heart disease","volume":"2015","author":"Devi","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_23","first-page":"Cd001800","article-title":"Exercise-based cardiac rehabilitation for coronary heart disease","volume":"11","author":"Dibben","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_24","first-page":"Cd010748","article-title":"Interventions to support return to work for people with coronary heart disease","volume":"3","author":"Hegewald","year":"2019","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_25","first-page":"Cd012786","article-title":"Exercise-based cardiac rehabilitation for adults with stable angina","volume":"2","author":"Long","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_26","first-page":"Cd007130","article-title":"Home-based versus centre-based cardiac rehabilitation","volume":"10","author":"McDonagh","year":"2023","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_27","first-page":"Cd002902","article-title":"Psychological interventions for coronary heart disease","volume":"4","author":"Richards","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_28","first-page":"Cd008012","article-title":"Psychological and pharmacological interventions for depression in patients with coronary artery disease","volume":"12","author":"Tully","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_29","first-page":"Cd006886","article-title":"Psychosocial interventions for smoking cessation in patients with coronary heart disease","volume":"2015","author":"Barth","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_30","first-page":"Cd003836","article-title":"Bed rest for acute uncomplicated myocardial infarction","volume":"2007","author":"Herkner","year":"2007","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_31","first-page":"Cd004101","article-title":"Psychological interventions for symptomatic management of non-specific chest pain in patients with normal coronary anatomy","volume":"2015","author":"Kisely","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_32","first-page":"Cd009506","article-title":"Yoga for secondary prevention of coronary heart disease","volume":"2015","author":"Kwong","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"384","DOI":"10.23736\/S1973-9087.19.05808-8","article-title":"How to use the International Classification of Functioning, Disability and Health as a reference system for comparative evaluation and standardized reporting of rehabilitation interventions","volume":"55","author":"Stucki","year":"2019","journal-title":"Eur. J. Phys. Rehabil. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.cjca.2020.02.072","article-title":"Cardiac Rehabilitation Programs for Chronic Heart Disease: A Bayesian Network Meta-analysis","volume":"37","author":"Huang","year":"2021","journal-title":"Can J. Cardiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1093\/eurheartj\/ehac747","article-title":"Exercise-based cardiac rehabilitation for coronary heart disease: A meta-analysis","volume":"44","author":"Dibben","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1093\/eurheartj\/ehq236","article-title":"Secondary prevention through cardiac rehabilitation: Physical activity counselling and exercise training: Key components of the position paper from the Cardiac Rehabilitation Section of the European Association of Cardiovascular Prevention and Rehabilitation","volume":"31","author":"Piepoli","year":"2010","journal-title":"Eur. Heart J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"695","DOI":"10.4330\/wjc.v13.i12.695","article-title":"Current role and future perspectives of cardiac rehabilitation in coronary heart disease","volume":"13","author":"Vilela","year":"2021","journal-title":"World J. Cardiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1161\/CIRCULATIONAHA.122.061046","article-title":"A New Era in Cardiac Rehabilitation Delivery: Research Gaps, Questions, Strategies, and Priorities","volume":"147","author":"Beatty","year":"2023","journal-title":"Circulation"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/13\/3662\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:03:14Z","timestamp":1760108594000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/13\/3662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,23]]},"references-count":38,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["jcm13133662"],"URL":"https:\/\/doi.org\/10.3390\/jcm13133662","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,23]]}}}