{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:26:22Z","timestamp":1790972782288,"version":"4.1.0"},"reference-count":27,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Periprocedural blood pressure changes in stroke patients with a large vessel occlusion are a known modifiable risk factor of unfavorable treatment outcomes. We aimed to evaluate the association between pre-revascularization hypotension and the final infarct volume. Methods: In our retrospective analysis, we included 214 consecutive stroke patients with an anterior circulation large vessel occlusion that underwent mechanical thrombectomy under general anesthesia. Noninvasively obtained blood pressure values prior to symptomatic vessel recanalization were analyzed as a predictor of post-treatment infarct size. Linear logistic regression models adjusted for predefined factors were used to investigate the association between blood pressure parameters and the final infarct volume. Results: In our cohort, higher baseline systolic blood pressure (a\u03b2 = 8.32, 95% CI 0.93\u201315.7, p = 0.027), its maximal absolute drop (a\u03b2 = 6.98, 95% CI 0.42\u201313.55, p = 0.037), and &gt;40% mean arterial pressure decrease (a\u03b2 = 41.77, CI 95% 1.93\u201381.61, p = 0.040) were independently associated with higher infarct volumes. Similarly, continuous hypotension measured as intraprocedural cumulative time spent below either 100 mmHg (a\u03b2 = 3.50 per 5 min, 95% CI 1.49\u20135.50, p = 0.001) or 90 mmHg mean arterial pressure (a\u03b2 = 2.91 per 5 min, 95% CI 0.74\u20135.10, p = 0.010) was independently associated with a larger ischemia size. In the subgroup analysis of 151 patients with an M1 middle cerebral artery occlusion, two additional factors were independently associated with a larger ischemia size: systolic blood pressure maximal relative drop and &gt;40% drop from pretreatment value (a\u03b2 = 1.36 per 1% lower than baseline, 95% CI 0.04\u20132.67, p = 0.043, and a\u03b2 = 43.01, 95% CI 2.89\u201383.1, p = 0.036, respectively). No associations between hemodynamic parameters and post-treatment infarct size were observed in the cohort of intracranial internal carotid artery occlusion. Conclusions: In patients with ischemic stroke due to a proximal middle cerebral artery occlusion, higher pre-thrombectomy treatment systolic blood pressure is associated with a larger final infarct size. In patients treated under general anesthesia, hypotension prior to the M1 portion of middle cerebral artery recanalization is independently correlated with the post-treatment infarct volume. In this group, every 5 min spent below the mean arterial pressure threshold of 100 mmHg is associated with a 4 mL increase in ischemia volume on a post-treatment NCCT. No associations between blood pressure and final infarct volume were present in the subgroup of patients with an intracranial internal carotid artery occlusion.<\/jats:p>","DOI":"10.3390\/jcm13133707","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T12:46:56Z","timestamp":1719319616000},"page":"3707","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association between Transient-Continuous Hypotension during Mechanical Thrombectomy for Acute Ischemic Stroke and Final Infarct Volume in Patients with Proximal Anterior Circulation Large Vessel Occlusion"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3913-0841","authenticated-orcid":false,"given":"Marcin","family":"Wi\u0105cek","sequence":"first","affiliation":[{"name":"Department of Neurology, Institute of Medical Sciences, University of Rzeszow, 35-959 Rzeszow, Poland"},{"name":"Department of Neurology, Clinical Regional Hospital No. 2, 35-301 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabella","family":"Tomaszewska-Lampart","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Medical Sciences, University of Rzeszow, 35-959 Rzeszow, Poland"},{"name":"Department of Neurology, Clinical Regional Hospital No. 2, 35-301 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzena","family":"Dziedzic","sequence":"additional","affiliation":[{"name":"Department of Neurology, Clinical Regional Hospital No. 2, 35-301 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kaczorowska","sequence":"additional","affiliation":[{"name":"Department of Neurology, Clinical Regional Hospital No. 2, 35-301 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2860-6456","authenticated-orcid":false,"given":"Halina","family":"Bartosik-Psujek","sequence":"additional","affiliation":[{"name":"Department of Neurology, Institute of Medical Sciences, University of Rzeszow, 35-959 Rzeszow, Poland"},{"name":"Department of Neurology, Clinical Regional Hospital No. 2, 35-301 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1136\/neurintsurg-2018-014568","article-title":"European stroke organisation (ESO)\u2014European Society for Minimally Invasive Neurological Therapy (ESMINT) guidelines on mechanical Thrombectomy in acute ischemic stroke","volume":"11","author":"Turc","year":"2019","journal-title":"J. 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