{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:12:26Z","timestamp":1760145146452,"version":"build-2065373602"},"reference-count":38,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Introduction: Patients with chronic pancreatitis (CP) as well as with pancreatic head carcinoma (CA) undergo the surgical intervention named \u201cpylorus-preserving pancreatoduodenectomy according to Traverso\u2013Longmire (PPPD)\u201d, which allowed a comparative analysis of the postoperative courses. The hypothesis was that patients with CA would have worse general as well as immune status than patients with CP due to the severity of the tumor disease and that this would be reflected in the more disadvantageous early postoperative outcome after PPPD. Methods: With the aim of eliciting the influence of the different diagnoses, the surgical outcome of all consecutive patients who underwent surgery at the Dept. of General, Abdominal, Vascular and Transplant Surgery at the University Hospital at Magdeburg between 2002 and 2015 (inclusion criterion) was recorded and comparatively evaluated. Early postoperative outcome was characterized by general and specific complication rate indicating morbidity, mortality, and microbial colonization rate, in particular surgical site infection (SSI, according to CDC criteria). In addition, microbiological findings of swabs and cultures from all compartments as well as preoperative and perioperative parameters from patient records were retrospectively documented and used for statistical comparison in this systematic retrospective unicenter observational study (design). Results: In total, 192 cases with CA (68.1%) and 90 cases with CP (31.9%) met the inclusion criteria of this study. Surprisingly, there were similar specific complication rates of 45.3% (CA) vs. 45.6% (CP; p = 0.97) and in-hospital mortality, which differed only slightly at 3.65% (CA) vs. 3.3% (CP; p = 0.591); the overall complication rate tended to be higher for CA at 23.4% vs. 14.4% (CP; p = 0.082). Overall, potentially pathogenic germs were detected in 28.9% of all patients in CP compared to 32.8% in CA (p = 0.509), and the rate of SSI was 29.7% (CA) and 24.4% (CP; p = 0.361). In multivariate analysis, CA was found to be a significant risk factor for the development of SSI (OR: 2.025; p = 0.048); the underlying disease had otherwise no significant effect on early postoperative outcome. Significant risk factors in the multivariate analysis were also male sex for SSI and microbial colonization, and intraoperatively transfused red cell packs for mortality, general and specific complications, and surgical revisions. Conclusions: Based on these results, a partly significant, partly trending negative influence of the underlying disease CA, compared to CP, on the early postoperative outcome was found, especially with regard to SSI after PPPD. This influence is corroborated by the international literature.<\/jats:p>","DOI":"10.3390\/jcm13133810","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T09:06:07Z","timestamp":1719824767000},"page":"3810","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Surgical Outcome and Microbial Colonization of Standardized Smear Locations after Pancreatic Head Resection (Pylorus-Preserving Pancreatoduodenectomy, PPPD) for Chronic Pancreatitis and Pancreatic Head Carcinoma"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2082-6568","authenticated-orcid":false,"given":"Max","family":"Grabowski","sequence":"first","affiliation":[{"name":"Department of General, Abdominal, Vascular and Transplant Surgery, Otto-von-Guericke University Medical School with University Hospital, 39120 Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronny","family":"Otto","sequence":"additional","affiliation":[{"name":"Institute of Quality Assurance in Operative Medicine, 39120 Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"Tammer","sequence":"additional","affiliation":[{"name":"Synlab Medical Care Center Berlin GmbH, 10829 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1480-5200","authenticated-orcid":false,"given":"D\u00f6rthe","family":"Jechorek","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Otto-von-Guericke University Medical School with University Hospital, 39120 Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Ptok","sequence":"additional","affiliation":[{"name":"Department of General and Abdominal Surgery, Municipal Hospital (\u201cErnst-von Bergmann-Klinikum\u201d), 14467 Potsdam, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Al-Madhi","sequence":"additional","affiliation":[{"name":"Department of General, Abdominal, Vascular and Transplant Surgery, Otto-von-Guericke University Medical School with University Hospital, 39120 Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6248-7086","authenticated-orcid":false,"given":"Roland","family":"Croner","sequence":"additional","affiliation":[{"name":"Department of General, Abdominal, Vascular and Transplant Surgery, Otto-von-Guericke University Medical School with University Hospital, 39120 Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of General, Abdominal, Vascular and Transplant Surgery, Otto-von-Guericke University Medical School with University Hospital, 39120 Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"ref_1","unstructured":"Gesellschaft der epidemiologischen Krebsregister in Deutschland (2017). Pankreaskarzinom in Deutschland f\u00fcr 2017\/2018, Robert Koch Institute (RKI). (Abgerufen am 29.11.2022)."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1158\/0008-5472.CAN-14-0155","article-title":"Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States","volume":"74","author":"Rahib","year":"2014","journal-title":"Cancer Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1002\/cam4.767","article-title":"Projections of cancer incidence and cancer-related deaths in Germany by 2020 and 2030","volume":"5","author":"Quante","year":"2016","journal-title":"Cancer Med."},{"key":"ref_4","first-page":"1","article-title":"S3-Leitlinie zum exokrinen Pankreaskarzinom","volume":"1","author":"Seufferlein","year":"2021","journal-title":"Leitlinienprogr. Onkol. der AWMF DKG DHK"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/bjs.4881","article-title":"Randomized clinical trial of pylorus-preserving duodenopancreatectomy versus classical Whipple resection\u2014Long term results","volume":"92","author":"Seiler","year":"2005","journal-title":"Br. J. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1097\/01.sla.0000143248.71964.29","article-title":"Pylorus Preserving Pancreaticoduodenectomy Versus Standard Whipple Procedure","volume":"240","author":"Tran","year":"2004","journal-title":"Ann. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1055\/a-1735-3864","article-title":"S3-Leitlinie Pankreatitis\u2014Leitlinie der Deutschen Gesellschaft f\u00fcr Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) 1\u2014September 2021\u2014AWMF Registernummer 021-003","volume":"60","author":"Beyer","year":"2022","journal-title":"Z. Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1007\/s00268-012-1742-6","article-title":"Risk Factor of Surgical Site Infection after Pancreaticoduodenectomy","volume":"36","author":"Sugiura","year":"2012","journal-title":"World J. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00104-018-0654-x","article-title":"Untersuchungen zur Hospitalletalit\u00e4t in der Pankreaschirurgie","volume":"90","author":"Gastinger","year":"2019","journal-title":"Der. Chirurg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1097\/SLA.0000000000001693","article-title":"Nationwide In-hospital Mortality Following Pancreatic Surgery in Germany is Higher than Anticipated","volume":"264","author":"Nimptsch","year":"2016","journal-title":"Ann. Surg."},{"key":"ref_11","first-page":"319","article-title":"Pylorus Preserving Pancreaticoduodenectomy vs. Standard Whipple\u2019s Procedure in Case of Carcinoma head of the Pancreas and Periampullary Carcinoma","volume":"24","author":"Taher","year":"2015","journal-title":"Mymensingh Med. J."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Yang, C., Wu, H.-S., Chen, X.-L., Wang, C.-Y., Gou, S.-M., Xiao, J., He, Z.-Q., Chen, Q.-J., and Li, Y.-F. (2014). Pylorus-Preserving Versus Pylorus-Resecting Pancreaticoduodenectomy for Periampullary and Pancreatic Carcinoma: A Meta-Analysis. Hoffmann A-C, ed. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0090316"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jss.2015.12.053","article-title":"Delayed gastric emptying after pancreaticoduodenectomy","volume":"202","author":"Hanna","year":"2016","journal-title":"J. Surg. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s00534-012-0515-9","article-title":"Selection of prophylactic antibiotics according to the microorganisms isolated from surgical site infections (SSIs) in a previous series of surgeries reduces SSI incidence after pancreaticoduodenectomy","volume":"20","author":"Kondo","year":"2013","journal-title":"J. Hepatobiliary Pancreat. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/01.mpa.0000202959.63977.5c","article-title":"Increased Plasma Levels of IL-6 and IL-8 are Associated With Surgical Site Infection After Pancreaticoduodenectomy","volume":"32","author":"Kimura","year":"2006","journal-title":"Pancreas"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Suragul, W., Rungsakulkij, N., Vassanasiri, W., Tangtawee, P., Muangkaew, P., Mingphruedhi, S., and Aeesoa, S. (2020). Predictors of surgical site infection after pancreaticoduodenectomy. BMC Gastroenterol., 20.","DOI":"10.1186\/s12876-020-01350-8"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1001\/jamasurg.2015.4510","article-title":"Discordance Between Perioperative Antibiotic Prophylaxis and Wound Infection Cultures in Patients Undergoing Pancreaticoduodenectomy","volume":"151","author":"Fong","year":"2016","journal-title":"JAMA Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1002\/bjs.9899","article-title":"Impact of bacterial contamination of the abdominal cavity during pancreaticoduodenectomy on surgical-site infection","volume":"102","author":"Sugiura","year":"2015","journal-title":"Br. J. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.jiac.2018.05.007","article-title":"Risk factors for surgical site infection after major hepatobiliary and pancreatic surgery","volume":"24","author":"Takahashi","year":"2018","journal-title":"J. Infect. Chemother."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Popp, F.C., Popp, M.C., Zhao, Y., Betzler, C., Kropf, S., Garlipp, B., Benckert, C., Kalinski, T., Lippert, H., and Bruns, C.J. (2017). Protocol of the PANCALYZE trial: A multicenter, prospective study investigating the tumor biomarkers CXCR4, SMAD4, SOX9 and IFIT3 in patients with resected pancreatic adenocarcinoma to predict the pattern of recurrence of the disease. BMC Cancer, 17.","DOI":"10.1186\/s12885-017-3186-8"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s00534-009-0128-0","article-title":"Factors influencing infectious complications after pancreatoduodenectomy","volume":"17","author":"Su","year":"2010","journal-title":"J. Hepatobiliary Pancreat. Sci."},{"key":"ref_22","unstructured":"B\u00fcchler, M.W. (2014). Pylorus-preserving pancreaticoduodenectomy (pp Whipple) versus pancreaticoduodenectomy (classic Whipple) for surgical treatment of periampullary and pancreatic carcinoma. Cochrane Database of Systematic Reviews, John Wiley & Sons, Ltd."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1097\/SLA.0000000000002480","article-title":"Pylorus Resection Does Not Reduce Delayed Gastric Emptying After Partial Pancreatoduodenectomy","volume":"267","author":"Hackert","year":"2018","journal-title":"Ann. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1086\/646436","article-title":"CDC Definitions of Nosocomial Surgical Site Infections, 1992: A Modification of CDC Definitions of Surgical Wound Infections","volume":"13","author":"Horan","year":"1992","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s11596-015-1509-z","article-title":"Is there comparable morbidity in pylorus-preserving and pylorus-resecting pancreaticoduodenectomy? A meta-analysis","volume":"35","author":"Chen","year":"2015","journal-title":"J. Huazhong Univ. Sci. Technol. Med. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1001\/archsurg.2009.21","article-title":"Patient and hospital characteristics on the variance of perioperative outcomes for pancreatic resection in the United States\u2014Invited critique","volume":"144","author":"Farnell","year":"2009","journal-title":"Arch. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/bjs.9958","article-title":"Volume\u2013outcome relationship in pancreatic surgery","volume":"103","author":"Alsfasser","year":"2015","journal-title":"Br. J. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1007\/s00268-015-3115-4","article-title":"Determinants of Surgical Site Infections Following Pancreatoduodenectomy","volume":"39","author":"Barreto","year":"2015","journal-title":"World J. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1007\/s00268-016-3553-7","article-title":"Blood Transfusion is an Independent Risk Factor for Postoperative Serious Infectious Complications After Pancreaticoduodenectomy","volume":"40","author":"Zhang","year":"2016","journal-title":"World J. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.hpb.2016.07.011","article-title":"A novel, validated risk score to predict surgical site infection after pancreaticoduodenectomy","volume":"18","author":"Poruk","year":"2016","journal-title":"HPB"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1002\/bjs.9919","article-title":"Postoperative infectious complications after pancreatic resection","volume":"102","author":"Okano","year":"2015","journal-title":"Br. J. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1007\/s00595-017-1503-0","article-title":"Epidemiology and risk factors associated with surgical site infection after different types of hepatobiliary and pancreatic surgery","volume":"47","author":"Morikane","year":"2017","journal-title":"Surg. Today"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.surg.2017.05.016","article-title":"Postoperative infections represent a major determinant of outcome after pancreaticoduodenectomy: Results from a high-volume center","volume":"162","author":"Paiella","year":"2017","journal-title":"Surgery"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1007\/s00268-014-2688-7","article-title":"Perioperative Antibiotics Covering Bile Contamination Prevent Abdominal Infectious Complications after Pancreatoduodenectomy in Patients With Preoperative Biliary Drainage","volume":"38","author":"Sudo","year":"2014","journal-title":"World J. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e22714","DOI":"10.1097\/MD.0000000000022714","article-title":"The effect of preoperative biliary stents on outcomes after pancreaticoduodenectomy","volume":"99","author":"Gong","year":"2020","journal-title":"Medicine"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e1199","DOI":"10.1097\/MD.0000000000001199","article-title":"Effect of Preoperative Biliary Drainage on Complications Following Pancreatoduodenectomy","volume":"94","author":"Chen","year":"2015","journal-title":"Medicine"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.surg.2016.11.001","article-title":"Preoperative biliary stenting versus operation first in jaundiced patients due to malignant lesions in the pancreatic head: A meta-analysis of current literature","volume":"161","author":"Scheufele","year":"2017","journal-title":"Surgery"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.amjsurg.2017.01.033","article-title":"Standardization and streamlining of a pancreas surgery practice improves outcomes and resource utilization: A single institution\u2019s 20-year experience","volume":"214","author":"Stauffer","year":"2017","journal-title":"Am. J. Surg."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/13\/3810\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:07:19Z","timestamp":1760108839000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/13\/3810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,28]]},"references-count":38,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["jcm13133810"],"URL":"https:\/\/doi.org\/10.3390\/jcm13133810","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2024,6,28]]}}}