{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:53:05Z","timestamp":1792547585472,"version":"4.5.0"},"reference-count":85,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T00:00:00Z","timestamp":1719619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Scleral lenses (SLs) are large-diameter rigid contact lenses that are a mainstay treatment for eyes with corneal irregularities. In recent years, there has been increased interest in the role of managing dry eye disease (DED) with SLs, as many patients with DED have reported symptomatic relief with SL wear. The role of SLs for DED management when there are associated corneal irregularities is supported by individual case reports and studies. This has prompted practitioners to begin advocating using SLs in DED cases, even in the absence of associated corneal irregularities and other ocular surface diseases (OSDs). There have also been discussions on potentially placing SLs earlier in the treatment hierarchy of DED, where it currently sits at a more advanced level of intervention (Step 3) in the TFOS DEWS II Report. This review will present the currently available, albeit sparse, evidence that supports and suggests this practice, as well as ancillary evidence supporting the purported benefits of SL wear in DED. The advantages of SL wear, such as corneal healing, absence of tear evaporation and contact lens dehydration, and improved visual acuity with associated increased wear comfort, and how this will benefit DED patients will be explored. Conversely, the challenges associated with fitting SLs in DED patients, including increased midday fogging, poor wettability, and subjective patient satisfaction, will also be presented, as well as a discussion on the key considerations for SL fitting in this population. Overall, while more research is needed to support the use of SLs in DED patients without associated corneal irregularities and other forms of OSD, the use of these lenses may prove to have a potentially wider role given their reported ancillary benefits in these populations.<\/jats:p>","DOI":"10.3390\/jcm13133838","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T09:06:07Z","timestamp":1719824767000},"page":"3838","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Scleral Lenses for Managing Dry Eye Disease in the Absence of Corneal Irregularities: What Is the Current Evidence?"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5170-6316","authenticated-orcid":false,"given":"Sharon X.","family":"Qiu","sequence":"first","affiliation":[{"name":"Centre for Ocular Research & Education, School of Optometry & Vision Science, University of Waterloo, Waterloo, ON N2L 3G1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daddi","family":"Fadel","sequence":"additional","affiliation":[{"name":"Centre for Ocular Research & Education, School of Optometry & Vision Science, University of Waterloo, Waterloo, ON N2L 3G1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Hui","sequence":"additional","affiliation":[{"name":"Centre for Ocular Research & Education, School of Optometry & Vision Science, University of Waterloo, Waterloo, ON N2L 3G1, Canada"},{"name":"School of Optometry and Vision Science, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW 2052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.clae.2019.09.006","article-title":"The Official Guide to Scleral Lens Terminology","volume":"43","author":"Michaud","year":"2020","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.clae.2018.10.024","article-title":"Potential Contraindications to Scleral Lens Wear","volume":"42","author":"Fadel","year":"2019","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.clae.2014.02.002","article-title":"Modern Scleral Contact Lenses: A Review","volume":"37","author":"Bornman","year":"2014","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"101501","DOI":"10.1016\/j.clae.2021.101501","article-title":"Scleral Lens Prescription and Management Practices: Emerging Consensus","volume":"46","author":"Schornack","year":"2023","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II Definition and Classification Report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1097\/ICO.0b013e318155743d","article-title":"Boston Scleral Lens Prosthetic Device for Treatment of Severe Dry Eye in Chronic Graft-versus-host Disease","volume":"26","author":"Jacobs","year":"2007","journal-title":"Cornea"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jtos.2017.05.006","article-title":"TFOS DEWS II Management and Therapy Report","volume":"15","author":"Jones","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_8","first-page":"46","article-title":"Fast Forward to the Future: Envisaging the Future of Scleral Lenses","volume":"38","author":"Fadel","year":"2023","journal-title":"Contact Lens Spectr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/08164622.2021.1962210","article-title":"Beyond Dry Eye: How Co-Morbidities Influence Disease Phenotype in Dry Eye Disease","volume":"105","author":"Lee","year":"2022","journal-title":"Clin. Exp. Optom."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/ICU.0000000000000171","article-title":"Scleral Lens Use in Dry Eye Syndrome","volume":"26","author":"Bavinger","year":"2015","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.4103\/IJO.IJO_2778_22","article-title":"Contact Lenses in Dry Eye Disease and Associated Ocular Surface Disorders","volume":"71","author":"Chaudhary","year":"2023","journal-title":"Indian J. Ophthalmol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1097\/APO.0000000000000331","article-title":"Therapeutic Contact Lenses in the Treatment of Corneal and Ocular Surface Diseases\u2014A Review","volume":"9","author":"Lim","year":"2020","journal-title":"Asia-Pac. J. Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"DES36","DOI":"10.1167\/iovs.17-23500","article-title":"Irregular Astigmatism and Higher-Order Aberrations in Eyes with Dry Eye Disease","volume":"59","author":"Koh","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ajo.2015.11.034","article-title":"The Use of the Esclera Scleral Contact Lens in the Treatment of Moderate to Severe Dry Eye Disease","volume":"163","author":"Gomes","year":"2016","journal-title":"Am. J. Ophthalmol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1038\/s41598-021-82010-z","article-title":"Large Diameter Scleral Lens Benefits for Asians with Intractable Ocular Surface Diseases: A Prospective, Single-Arm Clinical Trial","volume":"11","author":"Moon","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/OPTO.S337920","article-title":"OSDI Outcomes Based on Patient Demographic and Wear Patterns in Prosthetic Replacement of the Ocular Surface Ecosystem","volume":"14","author":"Asghari","year":"2022","journal-title":"Clin. Optom."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Qiu, Y., Hong, J., and Peng, R. (2018). Manifestation of Clinical Categories of Ocular Graft-versus-Host Disease. J. Ophthalmol., 1\u20137.","DOI":"10.1155\/2018\/6430953"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"101721","DOI":"10.1016\/j.clae.2022.101721","article-title":"Outcomes of Scleral Lenses for Dry Eye Disease in Chronic Ocular Graft-versus-Host Disease","volume":"46","author":"Bae","year":"2023","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.2147\/OPTH.S337824","article-title":"Scleral Lens and Prosthetic Replacement of the Ocular Surface Ecosystem Utilization in Ocular Graft-versus-Host Disease: A Survey Study","volume":"15","author":"Bligdon","year":"2021","journal-title":"Clin. Ophthalmol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/bmt.2017.9","article-title":"Scleral Lenses for Severe Chronic GvHD-Related Keratoconjunctivitis Sicca: A Retrospective Study by the SFGM-TC","volume":"52","author":"Magro","year":"2017","journal-title":"Bone Marrow Transpl. Transplant."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/ICL.0b013e318188e205","article-title":"Jupiter Scleral Lenses in the Management of Chronic Graft Versus Host Disease","volume":"34","author":"Schornack","year":"2008","journal-title":"Eye Contact Lens Sci. Clin. Pract."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.bbmt.2007.05.006","article-title":"Use of Fluid-Ventilated, Gas-Permeable Scleral Lens for Management of Severe Keratoconjunctivitis Sicca Secondary to Chronic Graft-versus-Host Disease","volume":"13","author":"Takahide","year":"2007","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ajo.2016.03.020","article-title":"Ocular Manifestations of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Children","volume":"166","author":"Catt","year":"2016","journal-title":"Am. J. Ophthalmol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.ajo.2009.07.006","article-title":"Vision-Related Function after Scleral Lens Fitting in Ocular Complications of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis","volume":"148","author":"Delcampe","year":"2009","journal-title":"Am. J. Ophthalmol."},{"key":"ref_25","first-page":"659","article-title":"Contact Lens Management of a Case of Stevens-Johnson Syndrome: A Case Report","volume":"74","author":"Fine","year":"2003","journal-title":"Optometry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/ICL.0000000000000265","article-title":"Prosthetic Replacement of the Ocular Surface Ecosystem Scleral Lens Therapy for Exposure Keratopathy","volume":"43","author":"Chahal","year":"2017","journal-title":"Eye Contact Lens"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.4103\/IJO.IJO_3406_22","article-title":"Refractive Surgery and Dry Eye\u2014An Update","volume":"71","author":"Nair","year":"2023","journal-title":"Indian J. Ophthalmol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1097\/ICL.0000000000000919","article-title":"Benefits of Scleral Lens in the Management of Irregular Corneas and Dry Eye Syndrome After Refractive Surgery","volume":"48","author":"Marty","year":"2022","journal-title":"Eye Contact Lens"},{"key":"ref_29","unstructured":"Fadel, D., Wong, S., Luensmann, D., Gutherie, S., Woods, J., Votlz, K., and Vega, J. (2024, January 20). The Use of Scleral Lenses to Manage Dry Eye Symptoms in Habitual Soft Lens Wearers. Proceedings of the Global Specialty Lens Symposium, Las Vegas, NV, USA."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Wong, S., Fadel, D., Seo, J., Luensmann, D., Gutherie, S., Woods, J., Votlz, K., and Vega, J. (2024, January 10). Dry Eye Management with Scleral Lenses in Non-lens Wearers. Paper Presentation at the Netherlands Contact Lens Congress, Veldhoven, The Netherlands.","DOI":"10.1016\/j.clae.2024.102201"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jtos.2017.03.006","article-title":"TFOS DEWS II Tear Film Report","volume":"15","author":"Willcox","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"101407","DOI":"10.1016\/j.clae.2021.01.002","article-title":"Anatomical and Physiological Considerations in Scleral Lens Wear: Eyelids and Tear Film","volume":"44","author":"Walker","year":"2021","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"TFOS123","DOI":"10.1167\/iovs.13-13235","article-title":"The TFOS International Workshop on Contact Lens Discomfort: Report of the Contact Lens Interactions with the Tear Film Subcommittee","volume":"54","author":"Craig","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_34","first-page":"21","article-title":"Tear Film Examination of the Contact Lens Patient","volume":"206","author":"Guillon","year":"1993","journal-title":"Optician"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/ICL.0b013e31818c5d00","article-title":"Contact Lens Wear Affects Tear Film Evaporation","volume":"34","author":"Guillon","year":"2008","journal-title":"Eye Contact Lens"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"8811","DOI":"10.1167\/iovs.10-6841","article-title":"Effect of Controlled Adverse Chamber Environment Exposure on Tear Functions in Silicon Hydrogel and Hydrogel Soft Contact Lens Wearers","volume":"52","author":"Kojima","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/00006324-200403000-00012","article-title":"Effect of Contact Lens Materials on Tear Physiology","volume":"81","author":"Thai","year":"2004","journal-title":"Optom. Vis. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00006324-198303000-00004","article-title":"A Comparative Study of Tear Evaporation Rates and Water Content of Soft Contact Lenses","volume":"60","author":"Cedarstaff","year":"1983","journal-title":"Am. J. Optom. Physiol. Opt."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"TFOS37","DOI":"10.1167\/iovs.13-13215","article-title":"The TFOS International Workshop on Contact Lens Discomfort: Report of the Contact Lens Materials, Design, and Care Subcommittee","volume":"54","author":"Jones","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1002\/jbm.b.33057","article-title":"Influence of Environmental Factors in the in Vitro Dehydration of Hydrogel and Silicone Hydrogel Contact Lenses","volume":"102","author":"Arroyo","year":"2014","journal-title":"J. Biomed. Mater. Res. Part. B Appl. Biomater."},{"key":"ref_41","first-page":"233","article-title":"The On-Eye Dehydration of Proclear Compatibles Lenses","volume":"25","author":"Hall","year":"1999","journal-title":"CLAO J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1097\/00006324-199910000-00021","article-title":"Hydrogel Lens Dehydration and Subjective Comfort and Dryness Ratings in Symptomatic and Asymptomatic Contact Lens Wearers","volume":"76","author":"Fonn","year":"1999","journal-title":"Optom. Vis. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1097\/01.opx.0000135103.94039.40","article-title":"Impact of Manufacturing Technology and Material Composition on the Clinical Performance of Hydrogel Lenses","volume":"81","author":"Efron","year":"2004","journal-title":"Optom. Vis. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1167\/iovs.05-1392","article-title":"Tear Film, Contact Lens, and Patient-Related Factors Associated with Contact Lens-Related Dry Eye","volume":"47","author":"Nichols","year":"2006","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.clae.2016.04.009","article-title":"The Influence of Rigid Gas Permeable Lens Wear on the Concentrations of Dinucleotides in Tears and the Effect on Dry Eye Signs and Symptoms in Keratoconus","volume":"39","author":"Carracedo","year":"2016","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/ICL.0000000000000153","article-title":"Symptoms and Signs in Rigid Gas Permeable Lens Wearers During Adaptation Period","volume":"42","author":"Carracedo","year":"2016","journal-title":"Eye Contact Lens"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.clae.2018.09.004","article-title":"Case Series: Extended Wear of Rigid Gas Permeable Scleral Contact Lenses for the Treatment of Persistent Corneal Epithelial Defects","volume":"42","author":"Khan","year":"2019","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1016\/j.bbmt.2015.07.027","article-title":"Use of Prosthetic Replacement of the Ocular Surface Ecosystem Scleral Lenses in Patients with Ocular Chronic Graft-versus-Host Disease","volume":"21","author":"Theophanous","year":"2015","journal-title":"Biol. Blood Marrow Transpl. Transplant."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.clae.2018.07.007","article-title":"Visual and physiological outcomes of scleral lens wear","volume":"42","author":"Schornack","year":"2019","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_50","first-page":"13","article-title":"Case Report: Scleral Lens Management in a Case of Neurotrophic Keratitis Caused by Acoustic Neuroma","volume":"2","author":"Qiu","year":"2024","journal-title":"Clin. Insights Eyecare"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/ICO.0b013e31825fed01","article-title":"Scleral Contact Lenses as an Alternative to Tarsorrhaphy for the Long-Term Management of Combined Exposure and Neurotrophic Keratopathy","volume":"32","author":"Weyns","year":"2013","journal-title":"Cornea"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.clae.2012.07.009","article-title":"Scleral Contact Lens Management of Bilateral Exposure and Neurotrophic Keratopathy","volume":"35","author":"Grey","year":"2012","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_53","unstructured":"(2024, March 18). Outcomes of Scleral Lens Therapy in Patients with Neurotrophic Keratopathy at a Tertiary Referral Center|IOVS|ARVO Journals. Available online: https:\/\/iovs.arvojournals.org\/article.aspx?articleid=2690118."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"101387","DOI":"10.1016\/j.clae.2020.11.007","article-title":"The association of comfort and vision in soft toric contact lens wear","volume":"44","author":"Read","year":"2021","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/ICL.0000000000000743","article-title":"The Relationship between Vision and Comfort in Contact Lens Wear","volume":"47","author":"Diec","year":"2021","journal-title":"Eye Contact Lens"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1097\/OPX.0000000000001570","article-title":"Optical Quality and Visual Performance for One Year in a Sample of Scleral Lens Wearers","volume":"97","author":"McAlinden","year":"2020","journal-title":"Optom. Vis. Vision. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.22374\/jclrs.v5i1.40","article-title":"Influence of the Scleral Lens and Fluid Reservoir Thicknesses on Residue Astigmatism","volume":"5","author":"Michaud","year":"2021","journal-title":"J. Contact Lens Res. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.clae.2015.08.003","article-title":"Complications and Fitting Challenges Associated with Scleral Contact Lenses: A Review","volume":"39","author":"Walker","year":"2016","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1167\/iovs.18-24664","article-title":"Identification of Leukocytes Associated with Midday Fogging in the Post-Lens Tear Film of Scleral Contact Lens Wearers","volume":"60","author":"Postnikoff","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.clae.2020.03.005","article-title":"Factors Associated with Patient-Reported Midday Fogging in Established Scleral Lens Wearers","volume":"43","author":"Schornack","year":"2020","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/ICL.0000000000001051","article-title":"Patient Experiences with Therapeutic Contact Lenses and Dry Eye Disease","volume":"50","author":"Shorter","year":"2024","journal-title":"Eye Contact Lens"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/opo.13293","article-title":"Lens and Solution Properties in Patients with and without Midday Fogging","volume":"44","author":"Fogt","year":"2024","journal-title":"Ophthalmic Physiol. Opt."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2147\/OPTO.S284634","article-title":"Midday Fogging of Scleral Contact Lenses: Current Perspectives","volume":"13","author":"Fogt","year":"2021","journal-title":"Clin. Optom."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.clae.2020.02.017","article-title":"Scleral Lens Wear: Measuring Inflammation in the Fluid Reservoir","volume":"43","author":"Walker","year":"2020","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.clae.2021.02.004","article-title":"BCLA CLEAR\u2014Contact Lens Wettability, Cleaning, Disinfection and Interactions with Tears","volume":"44","author":"Willcox","year":"2021","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/OPX.0b013e3181dc9a1a","article-title":"Contact Lenses Wettability In Vitro: Effect of Surface-Active Ingredients","volume":"87","author":"Lin","year":"2010","journal-title":"Optom. Vis. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/OPX.0000000000000138","article-title":"Factors in Contact Lens Symptoms: Evidence from a Multistudy Database","volume":"91","author":"Truong","year":"2014","journal-title":"Optom. Vis. Vision. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/OPX.0b013e31804636af","article-title":"Targeting Contact Lens Induced Dryness and Discomfort: What Properties Will Make Lenses More Comfortable","volume":"84","author":"Fonn","year":"2007","journal-title":"Optom. Vis. Vision. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1076\/ceyr.23.1.51.5418","article-title":"The Ex Vivo Wettability of Soft Contact Lenses","volume":"23","author":"Tonge","year":"2001","journal-title":"Curr. Eye Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"820","DOI":"10.18240\/ijo.2022.05.20","article-title":"Inflammation and Dry Eye Disease\u2014Where Are We?","volume":"15","author":"Rao","year":"2022","journal-title":"Int. J. Ophthalmol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2147\/OPTO.S284632","article-title":"How Can We Best Measure the Performance of Scleral Lenses? Current Insights","volume":"14","author":"Fadel","year":"2022","journal-title":"Clin. Optom."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/01.icl.0000228964.74647.25","article-title":"Modern Scleral Lenses Part II: Patient Satisfaction","volume":"33","author":"Visser","year":"2007","journal-title":"Eye Contact Lens"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S1542-0124(12)70095-2","article-title":"Contact Lens Strategies for the Patient with Dry Eye","volume":"5","author":"Sindt","year":"2007","journal-title":"Ocul. Surf."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1167\/iovs.08-1734","article-title":"Conjunctival and Corneal Pneumatic Sensitivity Is Associated with Signs and Symptoms of Ocular Dryness","volume":"49","author":"Situ","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1167\/iovs.14-16337","article-title":"The Impact of Conjunctivochalasis on Dry Eye Symptoms and Signs","volume":"56","author":"Chhadva","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.clae.2019.10.140","article-title":"A One-Year Prospective Study on Scleral Lens Wear Success","volume":"43","year":"2020","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.clae.2020.04.013","article-title":"A Review of the Compatibility of Topical Artificial Tears and Rewetting Drops with Contact Lenses","volume":"43","author":"Pucker","year":"2020","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_78","first-page":"e39324","article-title":"New Promising Therapeutic Approach for Refractory Corneal Epithelial Defects","volume":"15","author":"Moura","year":"2023","journal-title":"Cureus"},{"key":"ref_79","unstructured":"Van der Worp, E. (2010). A Guide to Scleral Lens Fitting, Pacific University College of Optometry. [2nd ed.]."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/ICL.0000000000000647","article-title":"Fitting Scleral Lenses Less Than 15 Mm in Diameter: A Review of the Literature","volume":"46","author":"Porcar","year":"2020","journal-title":"Eye Contact Lens"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/ICL.0000000000000523","article-title":"Scleral Lens Issues and Complications Related to a Non-Optimal Fitting Relationship between the Lens and Ocular Surface","volume":"45","author":"Fadel","year":"2019","journal-title":"Eye Contact Lens Sci. Clin. Pract."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"12","DOI":"10.22374\/jclrs.v1i1.11","article-title":"Qualitative Assessment of Scleral Shape Patterns Using a New Wide Field Ocular Surface Elevation Topographer","volume":"1","author":"DeNaeyer","year":"2017","journal-title":"J. Contact Lens Res. Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1097\/OPX.0000000000001559","article-title":"Changes in Symptoms of Midday Fogging with a Novel Scleral Contact Lens Filling Solution","volume":"97","author":"Fogt","year":"2020","journal-title":"Optom. Vis. Sci."},{"key":"ref_84","unstructured":"Fadel, D. (2020). Scleral Lens Issues & Complications. Their Recognition, Etiology, and Management, Dougmar Publishing Group."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/ICL.0000000000000754","article-title":"Assessment of a Novel Lens Surface Treatment for Scleral Lens Wearers with Dry Eye","volume":"47","author":"Mickles","year":"2021","journal-title":"Eye Contact Lens"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/13\/3838\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:07:55Z","timestamp":1760108875000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/13\/3838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,29]]},"references-count":85,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["jcm13133838"],"URL":"https:\/\/doi.org\/10.3390\/jcm13133838","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,29]]}}}